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Brain-wide analysis of neuronal network dynamics underlying adaptive and maladaptive emotional responses

Research Project

Project/Area Number 20H03556
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 51020:Cognitive and brain science-related
Research InstitutionOsaka University

Principal Investigator

Seiriki Kaoru  大阪大学, 大学院薬学研究科, 助教 (90802918)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2022: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2021: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2020: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywordsストレス / 神経科学 / イメージング / 情動 / 全脳イメージング / 社会性行動 / アデノ随伴ウイルスベクター / 共焦点顕微鏡 / 薬理学 / 神経化学
Outline of Research at the Start

情動反応には大脳皮質や視床下部、青斑核を代表とする多数の脳領域が関与し、それらの活動および連関はストレス等の外的要因を受けて時間的・空間的に変化すると考えられる。本研究では、これまでに構築に携わってきた新規全脳イメージング技術FASTの改良と神経活動の多色標識マウスの構築を通して、脳全体における神経活動の時間・空間変化の解析法を確立し、ストレスによる情動の適応と変容の機序における相違点や分岐過程の機序の理解を目指す。

Outline of Final Research Achievements

Neuronal mechanisms underlying different stress responses caused by physiological and pathological stress remain unclear. Using three-dimensional imaging analysis of stress-induced neuronal activity across the entire brain, we identified the neuronal populations and their circuit structures responsible for stress-induced emotional alterations depending on the stress states. Moreover, using our brain-wide analysis of axonal projection, we revealed the circuit structure of neuronal populations responsive to an antipsychotic drug.

Academic Significance and Societal Importance of the Research Achievements

ストレスによる情動変容の神経基盤を、脳全体の時間・空間的な神経活動変化に基づいて明らかにした本研究は、将来的にヒト疾患との関連性などを検証していくことによって、ストレス関連疾患の病態理解や、治療戦略の確立に貢献できる可能性が考えられる。また、本研究を通して確立してきた神経活動変化や神経回路構造の解析方法は、他の病態モデル動物や薬物の治療効果における神経回路レベルのメカニズムを理解するための研究への貢献が期待できる。

Report

(4 results)
  • 2023 Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (12 results)

All 2024 2023 2022 2021

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (7 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Clozapine Induces Neuronal Activation in the Medial Prefrontal Cortex in a Projection Target-Biased Manner2024

    • Author(s)
      Yumi Hirato, Kaoru Seiriki, Leo Kojima, Shohei Yamada, Hiroki Rokujo, Tomoya Takemoto, Takanobu Nakazawa, Atsushi Kasai, Hitoshi Hashimoto
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 47 Issue: 2 Pages: 478-485

    • DOI

      10.1248/bpb.b23-00898

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2024-02-22
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oxytocin ameliorates impaired social behavior in a mouse model of 3q29 deletion syndrome2022

    • Author(s)
      Takemoto Tomoya、Baba Masayuki、Yokoyama Kazumasa、Kitagawa Kohei、Nagayasu Kazuki、Ago Yukio、Seiriki Kaoru、Hayata-Takano Atsuko、Kasai Atsushi、Mori Daisuke、Ozaki Norio、Takuma Kazuhiro、Hashimoto Ryota、Hashimoto Hitoshi、Nakazawa Takanobu
    • Journal Title

      Molecular Brain

      Volume: 15 Issue: 1 Pages: 26-26

    • DOI

      10.1186/s13041-022-00915-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses.2022

    • Author(s)
      Niu M, Kasai A, Tanuma M, Seiriki K, Igarashi H, Kuwaki T, Nagayasu K, Miyaji K, Ueno H, Tanabe W, Seo K, Yokoyama R, Ohkubo J, Ago Y, Hayashida M, Inoue KI, Takada M, Yamaguchi S, Nakazawa T, Kaneko S, Okuno H, Yamanaka A, Hashimoto H.
    • Journal Title

      Science Advances

      Volume: 8 Issue: 11

    • DOI

      10.1126/sciadv.abi6375

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multiple alterations in glutamatergic transmission and dopamine D2 receptor splicing in induced pluripotent stem cell-derived neurons from patients with familial schizophrenia2021

    • Author(s)
      Yamamoto Kana、Kuriu Toshihiko、Takuma Kazuhiro、Ono Fumihito、Matsumoto Naomichi、Hashimoto Ryota、Hashimoto Hitoshi、Nakazawa Takanobu
    • Journal Title

      Translational Psychiatry

      Volume: 11 Issue: 1 Pages: 548-548

    • DOI

      10.1038/s41398-021-01676-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intranasal oxytocin administration ameliorates social behavioral deficits in a POGZWT/Q1038R mouse model of autism spectrum disorder2021

    • Author(s)
      Kitagawa Kohei、Matsumura Kensuke、Baba Masayuki、Kondo Momoka、Takemoto Tomoya、Nagayasu Kazuki、Ago Yukio、Seiriki Kaoru、Hayata-Takano Atsuko、Kasai Atsushi、Takuma Kazuhiro、Hashimoto Ryota、Hashimoto Hitoshi、Nakazawa Takanobu
    • Journal Title

      Molecular Brain

      Volume: 14 Issue: 1 Pages: 56-56

    • DOI

      10.1186/s13041-021-00769-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Whole-brain mapping of locus coeruleus noradrenergic projections in mice2023

    • Author(s)
      Kaoru Seiriki, Atsushi Kasai, Hitoshi Hashimoto
    • Organizer
      第66回日本神経化学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Development of an AAV vector for noradrenergic neuron-specific gene expression and application to mesoscale analysis of noradrenergic wiring diagrams in mice.2023

    • Author(s)
      Kaoru Seiriki, Shunsuke Maeda, Leo Kojima, Atsushi Kasai, Hitoshi Hashimoto
    • Organizer
      Neuroscience 2023
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of the medial prefrontal circuit responsive to the atypical antipsychotic drug clozapine2023

    • Author(s)
      Yumi Hirato, Kaoru Seiriki, Shohei Yamada, Leo Kojima, Atsushi Kasai, Takanobu Nakazawa, Hitoshi Hashimoto
    • Organizer
      第97回日本薬理学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Development of a noradrenergic neuron-selective AAV vector and brain-wide axonal mapping of social stress-responsive noradrenergic neurons2022

    • Author(s)
      Kaoru Seiriki, Shunsuke Maeda, Yuzuka Fujimoto, Shohei Yamada, Yumi Hirato, Atsushi Kasai, Hitoshi Hashimoto
    • Organizer
      Neuro2022(第45回日本神経科学大会・第65回日本神経化学会大会・第32回日本神経回路学会大会)
    • Related Report
      2021 Annual Research Report
  • [Presentation] Social defeat stress induces activation of PACAP-expressing neurons in thermoregulatory systems2022

    • Author(s)
      Yuzuka Fujimoto, Kaoru Seiriki, Shunsuke Maeda, Taiyou Baba, Atsuko Hayata-Takano, Atsushi Kasai, Hitoshi Hashimoto
    • Organizer
      The 15th International Symposium on VIP, PACAP and Related Peptides The 1st International Society for BioactivePeptides Meeting
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a noradrenergic neuron-selective AAV vector and its application to the brain-wide axonal mapping2022

    • Author(s)
      Kaoru Seiriki, Shohei Yamada, Shunsuke Maeda, Yuzuka Fujimoto, Atsushi Kasai, Hitoshi Hashimoto
    • Organizer
      第95回日本薬理学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ストレスの強度に応じた社会性の低下に関与する神経基盤のイメージング解析2021

    • Author(s)
      前田駿介、藤本柚香、勢力薫、山田翔平、平戸祐充、馬場太陽、児島励央、疋田貴俊、笠井淳司、橋本均
    • Organizer
      第140回薬理学会近畿部会
    • Related Report
      2020 Annual Research Report

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Published: 2020-04-28   Modified: 2025-01-30  

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