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Integrated genome-wide association study in sepsis

Research Project

Project/Area Number 20H03779
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 55060:Emergency medicine-related
Research InstitutionChiba University

Principal Investigator

中田 孝明  千葉大学, 大学院医学研究院, 教授 (20375794)

Co-Investigator(Kenkyū-buntansha) 関根 章博  千葉大学, 大学院医学研究院, 特任教授 (30425631)
島田 忠長  千葉大学, 医学部附属病院, 助教 (40436423)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Granted (Fiscal Year 2021)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2022: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2021: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2020: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Keywords敗血症 / 遺伝子多型 / ゲノム / 網羅解析
Outline of Research at the Start

敗血症は依然致死率が高く,新規発見が必要な重要課題で,遺伝的要因の個人差である遺伝子多型が敗血症の転帰に影響を与えることが広く知られている.本研究は敗血症細胞モデル・敗血症/関連疾患患者コホートを用いた複数のゲノムワイド関連解析(Genome-Wide Association Study, GWAS),次世代シーケンサー(Next Generation Sequencer, NGS)を用いた網羅解析結果を統合し,敗血症の転帰に影響を与える多くの新規遺伝子多型を発見し,個別化医療の礎を築く.

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Published: 2020-04-28   Modified: 2022-04-19  

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