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Study on neural mechanism of swallowing by imaging

Research Project

Project/Area Number 20H03850
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 57010:Oral biological science-related
Research InstitutionTohoku University

Principal Investigator

Junichi Nakai  東北大学, 歯学研究科, 教授 (80237198)

Co-Investigator(Kenkyū-buntansha) 荒田 晶子  兵庫医科大学, 医学部, 准教授 (00266082)
安藤 恵子  東北大学, 歯学研究科, 准教授 (40221741)
中村 卓史  東北大学, 歯学研究科, 准教授 (90585324)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2022: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2021: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywords呼吸 / 嚥下 / イメージング / Munc18-1 / バリン / 感覚 / 唾液腺 / 舌運動 / 脳幹部 / 運動 / 味覚 / 神経機構 / 神経回路 / 誤嚥性肺炎
Outline of Research at the Start

高齢化が進む我が国において、肺炎は死亡率の上昇傾向が続き、2011年には脳血管疾患を抜いて我が国の死亡率第3位となっている。肺炎患者の約7割が75歳以上の高齢者であり、また、高齢者の肺炎のうち、7割以上が誤嚥性肺炎によるものである。したがって、誤嚥性肺炎を引き起こす嚥下障害に対する対策が重要である。
基礎歯科分野においては、嚥下障害に関連する嚥下のメカニズム、特に嚥下の神経回路機構はまだ十分解明されていない。そのため、本研究では嚥下の神経機構の解明を行う。
意義:本研究の成果は、嚥下障害の予防、治療や、リハビリに役立つ。また、誤嚥性肺炎による死亡を低下させると期待される。

Outline of Final Research Achievements

Elderly people are prone to aspiration pneumonia, but the mechanisms of respiration and swallowing that underlie aspiration pneumonia, particularly the neural circuit mechanisms involving the crosstalk between respiration and swallowing, have not yet been fully elucidated, and elucidation of these mechanisms is an urgent task. Analysis of the neural circuits involved in respiration and swallowing revealed that agglutination occurs within the cell body of GABA neurons, resulting in abnormal neural activity (convulsions). In addition, the effects of D-valine and L-valine on tongue and respiratory movements were examined, and it was found that D-valine induced more frequent tongue movements than L-valine. This study clarifies the basis of respiration and swallowing, and serves as a basis for preventing aspiration.

Academic Significance and Societal Importance of the Research Achievements

高齢化が進む我が国において、肺炎は死亡率第3位となっている。高齢者の肺炎のうち、7割以上が誤嚥性肺炎によるものである。呼吸と嚥下は密接に関連していることがわかっている。本研究は、呼吸と嚥下のクロストークを含む神経回路機構を解明するものであり、嚥下中枢と呼吸中枢とのクロストークの神経機構が解明され、嚥下による気道防衛の機構の解明が進んだ。本研究で得られる呼吸・嚥下機構に関する基礎生理学的成果を誤嚥性肺炎の予防、治療や、リハビリに役立てることにより、健康長寿社会の実現に貢献する。また、呼吸や嚥下運動を円滑に行うための医薬品の開発につながる可能性がある。

Report

(4 results)
  • 2023 Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • Research Products

    (19 results)

All 2024 2023 2021 2020

All Journal Article (12 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 12 results,  Open Access: 12 results) Presentation (7 results) (of which Int'l Joint Research: 5 results,  Invited: 2 results)

  • [Journal Article] Physical Stimulation Methods Developed for In Vitro Neuronal Differentiation Studies of PC12 Cells: A Comprehensive Review2024

    • Author(s)
      Tominami Kanako、Kudo Tada-aki、Noguchi Takuya、Hayashi Yohei、Luo You-Ran、Tanaka Takakuni、Matsushita Ayumu、Izumi Satoshi、Sato Hajime、Gengyo-Ando Keiko、Matsuzawa Atsushi、Hong Guang、Nakai Junichi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 25 Issue: 2 Pages: 772-772

    • DOI

      10.3390/ijms25020772

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Virtual reality-based real-time imaging reveals abnormal cortical dynamics during behavioral transitions in a mouse model of autism2023

    • Author(s)
      Nakai Nobuhiro、Sato Masaaki、Yamashita Okito、Sekine Yukiko、Fu Xiaochen、Nakai Junichi、Zalesky Andrew、Takumi Toru
    • Journal Title

      Cell Reports

      Volume: - Issue: 4 Pages: 112258-112258

    • DOI

      10.1016/j.celrep.2023.112258

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficacy of exon-skipping therapy for DMD cardiomyopathy with mutations in actin binding domain 12023

    • Author(s)
      Shiba Naoko、Yang Xiao、Sato Mitsuto、Kadota Shin、Suzuki Yota、Agata Masahiro、Nagamine Kohei、Izumi Masaki、Honda Yusuke、Koganehira Tomoya、Kobayashi Hideki、Ichimura Hajime、Chuma Shinichiro、Nakai Junichi、Tohyama Shugo、Fukuda Keiichi、Miyazaki Daigo、Nakamura Akinori、Shiba Yuji
    • Journal Title

      Molecular Therapy - Nucleic Acids

      Volume: 34 Pages: 102060-102060

    • DOI

      10.1016/j.omtn.2023.102060

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A humanized Caenorhabditis elegans model for studying pathogenic mutations in VPS45, a protein essential for membrane trafficking, associated with severe congenital neutropenia.2023

    • Author(s)
      Gengyo-Ando K, Tateyama M, Mitani S, Ando H, Nakai J.
    • Journal Title

      MicroPubl Biol.

      Volume: 10 Pages: 001052-001052

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Domain 3a mutation of VPS33A suppresses larval arrest phenotype in the loss of VPS45 in Caenorhabditis elegans.2023

    • Author(s)
      Gengyo-Ando K, Kumagai M, Ando H, Nakai J.
    • Journal Title

      MicroPubl Biol.

      Volume: 10 Pages: 001155-001155

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modality-Specific Impairment of Hippocampal CA1 Neurons of Alzheimer’s Disease Model Mice2021

    • Author(s)
      Takamura Risa、Mizuta Kotaro、Sekine Yukiko、Islam Tanvir、Saito Takashi、Sato Masaaki、Ohkura Masamichi、Nakai Junichi、Ohshima Toshio、Saido Takaomi C.、Hayashi Yasunori
    • Journal Title

      The Journal of Neuroscience

      Volume: 41 Issue: 24 Pages: 5315-5329

    • DOI

      10.1523/jneurosci.0208-21.2021

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fast, cell-resolution, contiguous-wide two-photon imaging to reveal functional network architectures across multi-modal cortical areas2021

    • Author(s)
      K. Ota, Y. Oisi, T. Suzuki, M. Ikeda, Y. Ito, T. Ito, H. Uwamori, K. Kobayashi, M. Kobayashi, M. Odagawa, C. Matsubara, Y. Kuroiwa, M. Horikoshi, J. Matsushita, H. Hioki, M. Ohkura, J. Nakai, M. Oizumi, A. Miyawaki, T. Aonishi, T. Ode and M. Murayama
    • Journal Title

      Neuron

      Volume: - Issue: 11 Pages: 1-15

    • DOI

      10.1016/j.neuron.2021.03.032

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Global knockdown of glutamate decarboxylase 67 elicits emotional abnormality in mice.2021

    • Author(s)
      Miyata S, Kakizaki T, Fujihara K, Obinata H, Hirano T, Nakai J, Tanaka M, Itohara S, Watanabe M, Tanaka KF, Abe M, Sakimura K, Yanagawa Y.
    • Journal Title

      Mol Brain

      Volume: 14 Issue: 1 Pages: 5-5

    • DOI

      10.1186/s13041-020-00713-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Machine learning enables improved runtime and precision for bio-loggers on seabirds2020

    • Author(s)
      Korpela Joseph、Suzuki Hirokazu、Matsumoto Sakiko、Mizutani Yuichi、Samejima Masaki、Maekawa Takuya、Nakai Junichi、Yoda Ken
    • Journal Title

      Communications Biology

      Volume: 3 Issue: 1 Pages: 633-633

    • DOI

      10.1038/s42003-020-01356-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cellular identity and Ca2+ signaling activity of the non-reproductive GnRH system in the Ciona intestinalis type A (Ciona robusta) larva2020

    • Author(s)
      Okawa Nanako、Shimai Kotaro、Ohnishi Kohei、Ohkura Masamichi、Nakai Junichi、Horie Takeo、Kuhara Atsushi、Kusakabe Takehiro G.
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 18590-18590

    • DOI

      10.1038/s41598-020-75344-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Encoding of social exploration by neural ensembles in the insular cortex2020

    • Author(s)
      Miura I, Sato M, Overton E, Kunori N, Nakai J, Kawamata T, Nakai N, Takumi T.
    • Journal Title

      PLoS Biol.

      Volume: 18(9) Issue: 9 Pages: e3000584-e3000584

    • DOI

      10.1371/journal.pbio.3000584

    • NAID

      120006894010

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An aspherical microlens assembly for deep brain fluorescence microendoscopy2020

    • Author(s)
      Masaaki Sato*, Shotaro Sano, Hiroki Watanabe, Yoko Kudo, Junichi Nakai
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: in press Issue: 2 Pages: 447-452

    • DOI

      10.1016/j.bbrc.2020.04.009

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Investigation of the Frequency-Regulated Repeated Micro-Vibration (FRMV)-mediated osteoblast differentiation mechanism in MC3T3-E1 cells2023

    • Author(s)
      Ayumu Matsushita, Tada-aki Kudo, Yohei Hayashi, Kanako Tominami, Satoshi Izumi, Takakuni Tanaka, You-Ran Luo, Keiko Gengyo-Ando, Takuya Noguchi, Atsushi Matsuzawa, Guang Hong, Junichi Nakai
    • Organizer
      第101回日本生理学会大会
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Induction of neuronal differentiation in PC12-P1F1 cells by frequency-regulated micro-vibration.2021

    • Author(s)
      Luo Y, Kudo T, Tominami K, Izumi S, Hayashi Y, Noguchi T, Nakai J
    • Organizer
      International symposiumon on oral health science 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Association between the Gly16Arg polymorphism of human beta2-adrenergic receptor gene and food preferences.2021

    • Author(s)
      成田昂平, 工藤忠明, 洪光, 冨並香菜子, 泉哲, 林陽平, 中井淳一
    • Organizer
      第99回日本生理学会大会
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of temperature-controlled repeated thermal stimulation on osteoblast differentiation in MC3T3-E1 cell.2021

    • Author(s)
      冨並香菜子, 工藤忠明, 洪光, 羅悠然, 泉哲, 林陽平, 野口拓也, 松沢厚, 中井淳一
    • Organizer
      第99回日本生理学会大会
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SP600125 enhanced neurite outgrowth induced by temperature-controlled thermal stimulation in PC12-P1F1 cells.2021

    • Author(s)
      羅悠然, 工藤忠明, 冨並香菜子, 泉哲, 林陽平, 野口拓也, 松沢厚, 中井淳一, 洪光
    • Organizer
      第99回日本生理学会大会
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] GRINレンズと可変焦点レンズを用いたin vivo深部カルシウムイメージング2020

    • Author(s)
      中井淳一, 佐藤正晃, 大倉正道, 安藤恵子
    • Organizer
      日本薬理学会第71回北部会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] カルシウムプローブG-CaMPによるin vivo細胞機能イメージング2020

    • Author(s)
      中井淳一, 安藤恵子, 佐藤正晃, 大倉正道
    • Organizer
      歯科基礎医学会
    • Related Report
      2020 Annual Research Report
    • Invited

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Published: 2020-04-28   Modified: 2025-01-30  

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