A novel immuno-radiotherapy using autologus T cell and pH-responsive capsule for delivery of inorganic nanoparticles

• Project/Area Number: 20K21576
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Review Section: Medium-sized Section 52:General internal medicine and related fields
• Research Institution: Kobe University
• Principal Investigator: 佐々木 良平 神戸大学, 医学部附属病院, 教授 (30346267)
• Co-Investigator(Kenkyū-buntansha): 荻野 千秋 神戸大学, 工学研究科, 教授 (00313693) ; 赤坂 浩亮 神戸大学, 医学研究科, 非常勤講師 (20707161) ; 窪田 光 神戸大学, 医学部附属病院, 医員 (60824208)
• Project Period (FY): 2020-07-30 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2022: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ナノ粒子 / 免疫放射線療法 / 放射線応答 / 放射線増感 / がん幹細胞 / 放射線治療 / 表面修飾技術 / 免疫療法 / 放射線療法

Outline of Research at the Start

本研究は、CD8陽性-T細胞由来のエクソソームを単離し、過酸化チタンナノ粒子の運搬役として、新たな免疫放射線療法を提案する。CD8細胞の大量のエクソソームを過酸化チタンナノ粒子の運搬役とする。方法は、①過酸化チタンナノ粒子の粒子径の最適化、②自己血T細胞分離によるCD8の増幅エクソソーム回収、③エクソソーム・ナノ粒子結合体の効率的生成法の検討。タンニン酸を用いたMetal-Phenol Network法で生体親和性を持たせてエクソソームへの取り込みを可能にし、ケミカル免疫がん治療の開発する。

Outline of Annual Research Achievements

放射線治療は強い細胞傷害性をもつ有用な局所治療法であるが、治療経過に伴い腫瘍細胞 がPD-L1等の腫瘍抗原を発現が増強する事が報告され ている。この腫瘍抗原の増加によって、宿主の免疫細胞群による免疫システムが作動し、CD8細胞の膜表面上のPD-1と腫瘍細胞のPD-L1が免疫チェックポイントを形成し、更なる治療抵抗性の原因となる。これまで細胞傷害性のCD8細胞をがん治療に応用する試みは数々提案されてきたが、CD8細胞はその増幅が困難であり、固形癌ではその有用性は確認されていない。
過酸化チタンナノ粒子を表面修飾で電荷的に中性にし、pH反応性カプセル内に包含させ、その後タンニン酸を用いたMetal-Phenol Network（MPN法）で生体親和性を持たせ、エクソソームへの取り込みを可能にする。腫瘍細胞への特異的集積性の検討に関して、がん幹細胞に高発現しているCD44を認識する抗体と過酸化チタンナノ粒子を結合させることに成功し、CD44陽性細胞とCD44陰性細胞を用いたin vitroの実験系において腫瘍集積性の評価を行った。蛍光顕微鏡によるCD44陽性細胞またはCD44陰性細胞へのナノ粒子の取り込みを評価し、CD44陽性細胞内への有意な過酸化チタンナノ粒子の取り込み量の増加を認めた。腫瘍増殖抑制効果の検討に関して、タンニン酸を用いて無機分子・有機分子の結合体の作成の実験を進め、その合成に成功した。それらを用いて放射線照射の併用効果をコロニーアッセイにて評価した。CD44陽性細胞においては、過酸化チタンナノ粒子と放射線を併用することにより放射線単独または過酸化チタンナノ粒子単独よりも有意な腫瘍増殖抑制効果を認めた。これらの検討により、CD44を高頻度に発現するがん細胞へ高効率な過酸化チタンナノ粒子の輸送に成功した。

Research Products

• [Journal Article] Gold Nanoparticles Enhance the Tumor Growth-Suppressing Effects of Cetuximab and Radiotherapy in Head and Neck Cancer In Vitro and In Vivo (2023)
  • Author(s): Sato Takumi、Kakei Yasumasa、Hasegawa Takumi、Kashin Masahiko、Teraoka Shun、Yamaguchi Akinobu、Sasaki Ryohei、Akashi Masaya
  • Journal Title: Cancers Volume: 15 Issue: 23 Pages: 5697-5697
  • DOI: 10.3390/cancers15235697
  • Peer Reviewed / Open Access
• [Journal Article] Innovative Combination Treatment to Expand the Indications of Particle Therapy: Spacer Placement Surgery Using Bio-Absorbable Polyglycolic Acid Spacer (2023)
  • Author(s): Komatsu Shohei、Wang Tianyuan、Terashima Kazuki、Demizu Yusuke、Anzai Makoto、Suga Masaki、Yamashita Tomohiro、Suzuki Osamu、Okimoto Tomoaki、Sasaki Ryohei、Fukumoto Takumi
  • Journal Title: Journal of the American College of Surgeons Volume: 238 Issue: 1 Pages: 119-128
  • DOI: 10.1097/xcs.0000000000000873
  • Peer Reviewed / Open Access
• [Journal Article] Comparative study of sub-second temporal resolution 4D-MRI and 4D-CT for target motion assessment in a phantom model (2023)
  • Author(s): Wang Tianyuan、Sofue Keitaro、Shimada Ryuji、Ishihara Takeaki、Yada Ryuichi、Miyamoto Masanori、Sasaki Ryohei、Murakami Takamichi
  • Journal Title: Scientific Reports Volume: 13 Issue: 1 Pages: 15685-15685
  • DOI: 10.1038/s41598-023-42773-z
  • Peer Reviewed / Open Access
• [Journal Article] Radiomics and dosiomics for predicting complete response to definitive chemoradiotherapy patients with oesophageal squamous cell cancer using the hybrid institution model (2023)
  • Author(s): Kawahara Daisuke、Murakami Yuji、Awane Shota、Emoto Yuki、Iwashita Kazuma、Kubota Hikaru、Sasaki Ryohei、Nagata Yasushi
  • Journal Title: European Radiology Volume: 34 Issue: 2 Pages: 1200-1209
  • DOI: 10.1007/s00330-023-10020-8
  • Peer Reviewed / Open Access
• [Journal Article] Oncological outcomes of concurrent chemoradiotherapy with docetaxel, cisplatin, and 5‐fluorouracil for locally advanced squamous cell carcinoma of the external auditory canal: A single‐center study (2023)
  • Author(s): Yamada Akihiro、Shinomiya Hirotaka、Uehara Natsumi、Iritani Keisuke、Tatehara Shun、Furukawa Tatsuya、Teshima Masanori、Miyawaki Daisuke、Fujita Takeshi、Kakigi Akinobu、Kiyota Naomi、Sasaki Ryohei、Nibu Ken‐ichi
  • Journal Title: Head & Neck Volume: 45 Issue: 10 Pages: 2498-2504
  • DOI: 10.1002/hed.27461
  • Peer Reviewed
• [Journal Article] Assessing Therapeutic Response to Radium-223 with an Automated Bone Scan Index among Metastatic Castration-Resistant Prostate Cancer Patients: Data from Patients in the J-RAP-BSI Trial (2023)
  • Author(s): Kitajima Kazuhiro、Kuyama Junpei、Kawahara Takashi、Suga Tsuyoshi、Otani Tomoaki、Sugawara Shigeyasu、Kono Yumiko、Tamaki Yukihisa、Seko-Nitta Ayumi、Ishiwata Yoshinobu、Ito Kimiteru、Toriihara Akira、Watanabe Shiro、Hosono Makoto、Miyake Hideaki、Yamamoto Shingo、Sasaki Ryohei、Narita Mitsuhiro、Yamakado Koichiro
  • Journal Title: Cancers Volume: 15 Issue: 10 Pages: 2784-2784
  • DOI: 10.3390/cancers15102784
  • Peer Reviewed / Open Access
• [Journal Article] Multicenter retrospective study of stereotactic body radiotherapy for patients with previously untreated initial small hepatocellular carcinoma (2023)
  • Author(s): Doi Yoshiko、Nagata Yasushi、Matsumoto Yasuo、Numata Kazushi、Sasaki Ryu、Yamada Takashi、Igaki Hiroshi、Imagumbai Toshiyuki、Katoh Norio、Yoshitake Tadamasa、Shimizuguchi Takuya、Fujioka Den、Inoue Minoru、Koide Yutaro、Kimura Tomoki、Ito Yoshinori
  • Journal Title: Hepatology Research Volume: 53 Issue: 8 Pages: 749-760
  • DOI: 10.1111/hepr.13908
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Value of Radiomics Analysis of Skeletal Muscle After Radical Irradiation of Esophageal Cancer (2023)
  • Author(s): IWASHITA KAZUMA、KUBOTA HIKARU、NISHIOKA RIKU、EMOTO YUKI、KAWAHARA DAISUKE、ISHIHARA TAKEAKI、MIYAWAKI DAISUKE、NISHIBUCHI IKUNO、NAGATA YASUSHI、SASAKI RYOHEI
  • Journal Title: Anticancer Research Volume: 43 Issue: 4 Pages: 1749-1760
  • DOI: 10.21873/anticanres.16328
  • Peer Reviewed / Open Access
• [Journal Article] Ligation of the ethmoid arteries in superselective intra‐arterial infusion of cisplatin for advanced maxillary sinus cancer fed by the ophthalmic artery (2023)
  • Author(s): Tamagawa Kotaro、Shinomiya Hirotaka、Okada Takuya、Tatehara Shun、Teshima Masanori、Sasaki Ryohei、Nibu Ken‐ichi
  • Journal Title: Head & Neck Volume: 45 Issue: 5
  • DOI: 10.1002/hed.27341
  • Peer Reviewed / Open Access
• [Journal Article] 2-Hydroxyglutarate magnetic resonance spectroscopy in adult brainstem glioma. (2023)
  • Author(s): Iwahashi H, Nagashima H, Tanaka K, Uno T, Hashiguchi M, Maeyama M, Somiya Y, Komatsu M, Hirose T, Itoh T, Sasaki R, Sasayama T.
  • Journal Title: J Neurosurg Volume: 1 Issue: 2 Pages: 1-1
  • DOI: 10.3171/2022.12.jns221954
  • Peer Reviewed / Open Access
• [Journal Article] Reactive oxygen species-inducing titanium peroxide nanoparticles as promising radiosensitizers for eliminating pancreatic cancer stem cells (2022)
  • Author(s): Salah Mohammed、Akasaka Hiroaki、Shimizu Yasuyuki、Morita Kenta、Nishimura Yuya、Kubota Hikaru、Kawaguchi Hiroki、Sogawa Tomomi、Mukumoto Naritoshi、Ogino Chiaki、Sasaki Ryohei
  • Journal Title: Journal of Experimental & Clinical Cancer Research Volume: 41 Issue: 1 Pages: 146-146
  • DOI: 10.1186/s13046-022-02358-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] <i>In vivo</i> stealthified molecularly imprinted polymer nanogels incorporated with gold nanoparticles for radiation therapy (2022)
  • Author(s): Kitayama Yukiya、Yamada Takuya、Kiguchi Kentaro、Yoshida Aoi、Hayashi Shuhei、Akasaka Hiroaki、Igarashi Kazunori、Nishimura Yuya、Matsumoto Yu、Sasaki Ryohei、Takano Eri、Sunayama Hirobumi、Takeuchi Toshifumi
  • Journal Title: Journal of Materials Chemistry B Volume: 10 Issue: 35 Pages: 6784-6791
  • DOI: 10.1039/d2tb00481j
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Outcome of Patients with Pelvic and Retroperitoneal Bone and Soft Tissue Sarcoma: A Retrospective Multicenter Study in Japan (2022)
  • Author(s): Takemori Toshiyuki、Kawamoto Teruya、Hara Hitomi、et al.
  • Journal Title: Cancers Volume: 14 Issue: 12 Pages: 3023-3023
  • DOI: 10.3390/cancers14123023
  • Peer Reviewed / Open Access
• [Journal Article] The <i>TIGD5</i> gene located in 8q24 and frequently amplified in ovarian cancers is a tumor suppressor (2022)
  • Author(s): Dai Yuntao、Kawaguchi Tetsuya、Nishio Miki、Otani Junji、Tashiro Hironori、Terai Yoshito、Sasaki Ryohei、Maehama Tomohiko、Suzuki Akira
  • Journal Title: Genes to Cells Volume: 27 Issue: 11 Pages: 633-642
  • DOI: 10.1111/gtc.12980
  • Peer Reviewed / Open Access
• [Journal Article] Fiducial marker position affects target volume in stereotactic lung irradiation (2022)
  • Author(s): Akasaka Hiroaki、Mizonobe Kazufusa、Oki Yuya、Uehara Kazuyuki、Nakayama Masao、Tamura Shuhei、Munetomo Yoshiki、Kawaguchi Haruna、Ishida Jun、Harada Aya、Ishihara Takeaki、Kubota Hikaru、Kawaguchi Hiroki、Sasaki Ryohei、Mayahara Hiroshi
  • Journal Title: Journal of Applied Clinical Medical Physics Volume: ‐ Issue: 6 Pages: 1-10
  • DOI: 10.1002/acm2.13596
  • Peer Reviewed / Open Access
• [Journal Article] Blowing time ratio and high-resolution manometry to evaluate swallowing function of patients with oral and oropharyngeal cancer (2022)
  • Author(s): Komatsu Hirokazu、Furukawa Tatsuya、Iritani Keisuke、Tatehara Shun、Takahashi Miki、Iwaki Shinobu、Kakei Yasumasa、Hasegawa Takumi、Teshima Masanori、Shinomiya Hirotaka、Otsuki Naoki、Hashikawa Kazunobu、Kiyota Naomi、Sasaki Ryohei、Akashi Masaya、Nibu Ken-ichi
  • Journal Title: Auris Nasus Larynx Volume: 49 Issue: 3 Pages: 477-483
  • DOI: 10.1016/j.anl.2021.10.013
  • Peer Reviewed / Open Access
• [Journal Article] Roles of skull base surgery and particle radiotherapy for orbital malignant tumors involving the skull base (2021)
  • Author(s): Teshima Masanori、Shinomiya Hirotaka、Kimura Hidehito、Hashikawa Kazunobu、Kiyota Naomi、Miyawaki Daisuke、Sasaki Ryohei、Kohmura Eiji、Nibu Ken‐ichi
  • Journal Title: Laryngoscope Investigative Otolaryngology Volume: 6 Issue: 6 Pages: 1347-1352
  • DOI: 10.1002/lio2.687
  • NAID: 120007179199
  • Peer Reviewed / Open Access
• [Journal Article] Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy (2021)
  • Author(s): Nakayama Masao、Akasaka Hiroaki、Miyazaki Eiichi、Goto Yoshihiro、Oki Yuya、Kawate Yosuke、Morita Kenta、Sasaki Ryohei
  • Journal Title: Physics and Imaging in Radiation Oncology Volume: 20 Pages: 94-97
  • DOI: 10.1016/j.phro.2021.11.003
  • NAID: 120007179179
  • Peer Reviewed / Open Access
• [Journal Article] PET/MRI is useful for early detection of pelvic insufficiency fractures after radiotherapy for cervical cancer (2021)
  • Author(s): Azumi Maho、Matsumoto Masuyo、Suzuki Kaho、Sasaki Ryohei、Ueno Yoshiko、Nogami Munenobu、Terai Yoshito
  • Journal Title: Oncology Letters Volume: 22 Issue: 5 Pages: 776-776
  • DOI: 10.3892/ol.2021.13037
  • NAID: 120007153052
  • Peer Reviewed / Open Access
• [Journal Article] The feasibility of transcatheter arterial chemoembolization following radiation therapy for hepatocellular carcinoma (2021)
  • Author(s): Hamada Mostafa、Ueshima Eisuke、Ishihara Takeaki、Koide Yutaka、Okada Takuya、Horinouchi Hiroki、Ishida Jun、Mayahara Hiroshi、Sasaki Koji、Gentsu Tomoyuki、Sofue Keitaro、Yamaguchi Masato、Sasaki Ryohei、Sugimoto Koji、Murakami Takamichi
  • Journal Title: Acta Radiologica Open Volume: 10 Issue: 7 Pages: 20584-20584
  • DOI: 10.1177/20584601211034965
  • NAID: 120007153054
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Phase I trial of concurrent chemoradiotherapy with docetaxel, cisplatin and 5-fluorouracil (TPF-CRT) for locally advanced squamous cell carcinoma of the external auditory canal (2021)
  • Author(s): Shinomiya Hirotaka、Uehara Natsumi、Fujita Takeshi、Miyawaki Daisuke、Imamura Yoshinori、Teshima Masanori、Kakigi Akinobu、Kiyota Naomi、Sasaki Ryohei、Nibu Ken-ichi
  • Journal Title: European Archives of Oto-Rhino-Laryngology Volume: - Issue: 6 Pages: 2805-2810
  • DOI: 10.1007/s00405-021-06974-4
  • Peer Reviewed / Open Access
• [Journal Article] New proposal to revise the classification for squamous cell carcinoma of the external auditory canal and middle ear (2021)
  • Author(s): Shinomiya H、Uehara N、Fujita T、Yoshida K、Imamura Y、Teshima M、Kimura H、Miyawaki D、Kakigi A、Kiyota N、Otsuki N、Sasaki R、Kohmura E、Nibu K
  • Journal Title: The Journal of Laryngology &amp; Otology Volume: 135 Issue: 4 Pages: 297-303
  • DOI: 10.1017/s002221512100089x
  • NAID: 120007041636
  • Peer Reviewed / Open Access
• [Journal Article] Exosome-mediated radiosensitizing effect on neighboring cancer cells via increase in intracellular levels of reactive oxygen species (2021)
  • Author(s): Nakaoka Ai、Nakahana Makiko、Inubushi Sachiko、Akasaka Hiroaki、Salah Mohammed、Fujita Yoshiko、Kubota Hikaru、Hassan Mennaallah、Nishikawa Ryo、Mukumoto Naritoshi、Ishihara Takeaki、Miyawaki Daisuke、Sasayama Takashi、Sasaki Ryohei
  • Journal Title: Oncology Reports Volume: 45 Issue: 4 Pages: 1-1
  • DOI: 10.3892/or.2021.7964
  • NAID: 120006975755
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy of Spacers in Radiation Therapy for Locally Advanced Pancreatic Cancer: A Planning Study (2021)
  • Author(s): KAWAGUCHI HIROKI、DEMIZU YUSUKE、MUKUMOTO NARITOSHI、ISHIHARA TAKEAKI、MIYAWAKI DAISUKE、KOMATSU SHOHEI、AKASAKA HIROAKI、SHINOTO MAKOTO、SHIOYAMA YOSHIYUKI、NAKAMURA KATSUMASA、FUKUMOTO TAKUMI、SASAKI RYOHEI
  • Journal Title: Anticancer Research Volume: 41 Issue: 1 Pages: 503-508
  • DOI: 10.21873/anticanres.14801
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Surgical spacer placement for proton radiotherapy in locally advanced pancreatic body and tail cancers: initial clinical results (2021)
  • Author(s): Dongha Lee et al.
  • Journal Title: Radiation Oncology Volume: 16 Issue: 1 Pages: 1-11
  • DOI: 10.1186/s13014-020-01731-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Risk factors for osteoradionecrosis of the jaw in patients with head and neck squamous cell carcinoma (2021)
  • Author(s): Kubota Hikaru、Miyawaki Daisuke、Mukumoto Naritoshi、Ishihara Takeaki、Matsumura Megumi、Hasegawa Takumi、Akashi Masaya、Kiyota Naomi、Shinomiya Hirotaka、Teshima Masanori、Nibu Ken-ichi、Sasaki Ryohei
  • Journal Title: Radiation Oncology Volume: 16 Issue: 1 Pages: 1-1
  • DOI: 10.1186/s13014-020-01701-5
  • NAID: 120006954052
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The first pediatric case of sacral Ewing sarcoma treated with space‐making particle therapy (2021)
  • Author(s): Takagi Daisuke、Morikawa Yuri、Kamei Michi、Ogino Hiroyuki、Iwata Hiromitsu、Maeda Naoko、Akita Nobuhiro、Fukumoto Takumi、Sasaki Ryohei、Kondo Satoshi
  • Journal Title: Pediatric Blood &amp; Cancer Volume: 68 Issue: 5
  • DOI: 10.1002/pbc.28842
  • Peer Reviewed / Open Access
• [Journal Article] Titanium oxide nano-radiosensitizers for hydrogen peroxide delivery into cancer cells (2021)
  • Author(s): Morita Kenta、Nishimura Yuya、Nakamura Satoko、Arai Yuki、Numako Chiya、Sato Kazuyoshi、Nakayama Masao、Akasaka Hiroaki、Sasaki Ryohei、Ogino Chiaki、Kondo Akihiko
  • Journal Title: Colloids and Surfaces B: Biointerfaces Volume: 198 Pages: 111451-111451
  • DOI: 10.1016/j.colsurfb.2020.111451
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Surgical outcomes of metastatic bone tumors in the extremities (Surgical outcomes of bone metastases) (2021)
  • Author(s): Hara H、Sakai Y、Kawamoto T、Fukase N、Kawakami Y、Takemori T、Fujiwara S、Kitayama K、Yahiro S、Miyamoto T、Kakutani K、Niikura T、Miyawaki D、Okada T、Sakashita A、Imamura Y、Sasaki R、Kizawa Y、Minami H、Matsumoto T、Matsushita T、Kuroda R、Akisue T
  • Journal Title: Journal of Bone Oncology Volume: 27 Pages: 100352-100352
  • DOI: 10.1016/j.jbo.2021.100352
  • NAID: 120007038644
  • Peer Reviewed / Open Access
• [Journal Article] Elucidation of gastrointestinal dysfunction in response to irradiation using metabolomics (2020)
  • Author(s): Salah Mohammed、Osuga Saki、Nakahana Makiko、Irino Yasuhiro、Shinohara Masakazu、Shimizu Yasuyuki、Mukumoto Naritoshi、Akasaka Hiroaki、Nakaoka Ai、Miyawaki Daisuke、Ishihara Takeaki、Yoshida Kenji、Okamoto Yoshiaki、Sasaki Ryohei
  • Journal Title: Biochemistry and Biophysics Reports Volume: 23 Pages: 100789-100789
  • DOI: 10.1016/j.bbrep.2020.100789
  • NAID: 120007041619
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Comparative Assessment of Mechanisms and Effectiveness of Radiosensitization by Titanium Peroxide and Gold Nanoparticles (2020)
  • Author(s): Hassan Mennaallah、Nakayama Masao、Salah Mohammed、Akasaka Hiroaki、Kubota Hikaru、Nakahana Makiko、Tagawa Tatsuichiro、Morita Kenta、Nakaoka Ai、Ishihara Takeaki、Miyawaki Daisuke、Yoshida Kenji、Nishimura Yuya、Ogino Chiaki、Sasaki Ryohei
  • Journal Title: Nanomaterials Volume: 10 Issue: 6 Pages: 1125-1125
  • DOI: 10.3390/nano10061125
  • NAID: 120006878579
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Oncogenic miRNAs Identified in Tear Exosomes From Metastatic Breast Cancer Patients (2020)
  • Author(s): INUBUSHI SACHIKO、KAWAGUCHI HIROKI、MIZUMOTO SACHIKO、KUNIHISA TOMONARI、BABA MOTOI、KITAYAMA YUKIYA、TAKEUCHI TOSHIFUMI、HOFFMAN ROBERT M.、SASAKI RYOHEI
  • Journal Title: Anticancer Research Volume: 40 Issue: 6 Pages: 3091-3096
  • DOI: 10.21873/anticanres.14290
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Antibody-Conjugated Signaling Nanocavities Fabricated by Dynamic Molding for Detecting Cancers Using Small Extracellular Vesicle Markers from Tears (2020)
  • Author(s): Takeuchi Toshifumi、Mori Kisho、Sunayama Hirobumi、Takano Eri、Kitayama Yukiya、Shimizu Taku、Hirose Yuzuki、Inubushi Sachiko、Sasaki Ryohei、Tanino Hirokazu
  • Journal Title: Journal of the American Chemical Society Volume: 142 Issue: 14 Pages: 6617-6624
  • DOI: 10.1021/jacs.9b13874
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gold Nanoparticles Enhance EGFR Inhibition and Irradiation Effects in Head and Neck Squamous Carcinoma Cells (2020)
  • Author(s): Kashin Masahiko、Kakei Yasumasa、Teraoka Shun、Hasegawa Takumi、Yamaguchi Akinobu、Fukuoka Takao、Sasaki Ryohei、Akashi Masaya
  • Journal Title: BioMed Research International Volume: 2020 Pages: 1-10
  • DOI: 10.1155/2020/1281645
  • NAID: 120006940231
  • Peer Reviewed / Open Access
• [Presentation] Exosomes enhance the radiation sensitivity and metastasis via miR-6823-5p in pancreatic MIAPaCa-2 cell (2023)
  • Author(s): Ai Nakaoka*, Makiko Nakahana*, Sachiko Inubushi, Yasuyuki Shimizu*, Kazuma Iwashita*, Naritoshi Mukumoto*, Kana Kobayashi*, Takeaki Ishihara*, Daisuke Miyawaki* and Ryohei Sasaki*
  • Organizer: American Association of Cancer Research Annual Meeting 2023
  • Int'l Joint Research
• [Presentation] A novel radiosensitizer of titanium peroxide nanoparticles (TiOxNPs) through continuous ROS generation (2023)
  • Author(s): Ryohei Sasaki, Hiroaki Akasaka, Masao Nakayama, Yoshiko Fujita, Hikaru Kubota, Kenta Morita, Mennaallah Hassan, Mohammed Salah, Yuya Nishimura,Naritoshi Mukumoto, Takeaki Ishihara, Daisuke Miyawaki, Chiaki Ogino.
  • Organizer: American Association of Cancer Research Annual Meeting 2023
  • Int'l Joint Research
• [Presentation] Anti-tumor immunity evolved by novel titanium peroxide nanoparticles (TiOxNPs) as a radiosensitizer and PD-1 blockade (2023)
  • Author(s): Yoshiko Fujita, HIkaru Kubota, Chiaki Ogino, Ryohei Sasaki
  • Organizer: American Association of Cancer Research Annual Meeting 2023
  • Int'l Joint Research
• [Presentation] Titanium peroxides nanoparticles are promising radiosensitizers to eliminate pancreatic cancer stem cells (2023)
  • Author(s): Mohammed Salah, Hiroki Kawaguchi, Hiroaki Akasaka, Yasuyuki Shimizu, Kenta Morita, Yuya Nishimura, Hikaru Kubota, Tomomi Sogawa, NaritoshiMukumoto, Chiaki Ogino, Ryohei Sasaki.
  • Organizer: American Association of Cancer Research Annual Meeting 2023
  • Int'l Joint Research
• [Presentation] 放射線照射後の膵がん細胞由来エクソソームによる遊走能制御に関する基礎的検討 (2023)
  • Author(s): 中岡 藍*、仲波名 真希子*、張朱 睿賢*、山内 史人*、清水 康之*、岩下 和真*、梶原 彰文*、佐々木 理栄*、椋本 成俊*、小林 加奈*、石原 武明*、宮脇 大輔*、佐々木 良平*
  • Organizer: 日本放射線腫瘍学会第36回学術大会
• [Presentation] Biological reactions to extremely high dose rate X-ray irradiation to mouse brain and tumor models. (2022)
  • Author(s): Ryohei SASAKI, Naritoshi MUKUMOTO, Masao NAKAYAMA, Hiroaki AKASAKA, Yasuyuki SHIMIZU, Takeaki ISHIHARA, Daisuke MIYAWAKI
  • Organizer: 日本放射線影響学会 第65回大会
  • Invited
• [Presentation] エクソソームによる膵がん細胞の肝転移制御効果に関する基礎的検討 (2022)
  • Author(s): 中岡藍、仲波名真希子、清水康之、金城裕士、椋本成俊、小林加奈、石原武明、宮脇大輔、佐々木良平
  • Organizer: 日本放射線腫瘍学会第35回学術大会
• [Presentation] 膵がん細胞由来のエクソソームを介した肝転移制御効果に関する基礎的検討 (2022)
  • Author(s): 中岡藍、仲波名真希子、清水康之、金城裕士、椋本成俊、小林加奈、石原武明、宮脇大輔、佐々木良平
  • Organizer: 第9回日本細胞外小胞学会学術集会
• [Presentation] 同一腫瘍細胞間の放射線応答を制御するエクソソーム内マイクロRNAの網羅的解析 (2021)
  • Author(s): 中岡 藍、仲波名 真希子、椋本 成俊、赤坂 浩亮、清水 康之、Mohammed Salah、西川 遼、平野 駿太、石原 武明、宮脇 大輔、佐々木 良平
  • Organizer: 第58回日本放射線腫瘍学会生物部会学術大会
• [Presentation] エクソソーム内マイクロRNAを介した放射線応答制御に関する基礎的検討 (2021)
  • Author(s): 中岡藍、仲波名真希子、椋本成俊、赤坂浩亮、清水康之、Mohammed Salah、西川遼、平野駿太、石原武明、宮脇大輔、佐々木良平
  • Organizer: 第34回 日本放射線腫瘍学会学術大会
• [Presentation] Radiosensitive Effect induced by exosomes from irradiated cancer cells (2021)
  • Author(s): Ai Nakaoka, Makiko Nakahana, Naritoshi Mukumoto, Hiroaki Akasaka, Mohammed Salah, Ryo Nishikawa, Takeaki Ishihara, Daisuke Miyawaki, Takashi Sasayama and Ryohei Sasaki
  • Organizer: The 4 th International Cancer Research Symposium a Training for Oncology Professionals
  • Int'l Joint Research
• [Presentation] "Titanium Peroxide Nanoparticles with Radiation Covert Cold tumor into Hot tumor " (2021)
  • Author(s): Hikaru Kubota, Yoshiko Fujita, Mohammed Salah, Yasuyuki Shimizu, Daisuke Miyawaki, and Ryohei Sasaki
  • Organizer: The 4 th International Cancer Research Symposium a Training for Oncology Professionals
  • Int'l Joint Research
• [Presentation] エクソソームを介した腫瘍細胞への放射線増感効果 (2020)
  • Author(s): 中岡 藍、仲波名 真希子、椋本 成俊、赤坂 浩亮、清水 康之、Mohammed Salah、石原 武明 、宮脇 大輔、佐々木 良平
  • Organizer: 第63回日本放射線影響学会
• [Presentation] 過酸化チタンナノ粒子による免疫放射線治療増感効果の検討 (2020)
  • Author(s): 窪田 光、藤田 佳子、清水 康之、Mohammed Salah、岩下 和真、妹尾 悟史、川口 弘毅、小林 加奈、石原 武明、宮脇 大輔、吉田 賢史、西村 勇哉、荻野 千秋、佐々木 良平
  • Organizer: 第33回日本放射線腫瘍学会
• [Presentation] がん細胞から放出されたエクソソームによる放射線増感効果 (2020)
  • Author(s): 中岡 藍、仲波名 真希子、椋本 成俊、赤坂 浩亮、清水 康之、Mohammed Salah、石原 武明 、宮脇 大輔、佐々木 良平
  • Organizer: 第33回日本放射線腫瘍学会
• [Presentation] Titanium peroxide nanoparticle enhance the efficacy of immuno-radiotherapy via activated CD8+ T cell dependent antitumor effect in vivo (2020)
  • Author(s): Hikaru Kubota, Yoshiko Fujita, Mohammed Salah, Yasuyuki Shimizu, Hiroaki Akasaka, Ryohei Sasaki
  • Organizer: American Society for Radiation Oncology 62nd Annual Meeting
  • Int'l Joint Research
• [Book] Exrtacelluar vesicles (2021)
  • Author(s): Ai Nakaoka, Kana Kobayashi, Mennaallah Hassan and Ryohei Sasaki
  • Total Pages: 300
  • Publisher: Intech
• [Patent(Industrial Property Rights)] 医薬 (2023)
  • Inventor(s): 佐々木 良平、荻野 千秋、藤田 佳子
  • Industrial Property Rights Holder: 国立大学法人神戸大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2023-055654
  • Filing Date: 2023