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Development of in silico model for health impact assessment of Asbestos emitted from building materials

Research Project

Project/Area Number 20KK0099
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 23:Architecture, building engineering, and related fields
Research InstitutionKyushu University

Principal Investigator

Ito Kazuhide  九州大学, 総合理工学研究院, 教授 (20329220)

Co-Investigator(Kenkyū-buntansha) 劉 城準  九州大学, 総合理工学研究院, 准教授 (30783394)
牟田 諒太  九州大学, 総合理工学研究院, 技術職員 (40852629)
Project Period (FY) 2020-10-27 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2023: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2022: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2021: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Keywordsアスベスト / in silico model / 計算流体力学 / 経気道曝露 / 生理的薬物動態 / 数値気道モデル / 沈着 / 経気道暴露
Outline of Research at the Start

本研究は,建材からの飛散,浮遊,呼吸に伴う体内吸収までの一連の経気道曝露メカニズムと,発症に至る健康リスクを定量的に予測評価する数値解析モデル(in silico model)を確立し,アスベスト健康被害を最小化するための工学手法開発のための基盤技術を整備する.

Outline of Final Research Achievements

In this study, we created an in silico airway model, which serves as a numerical platform for integrating medical in vivo and in vitro test results on respiratory exposure to asbestos fibers. Furthermore, we developed Euler-Lagrange type numerical analysis model to quantitatively predict the transport of asbestos fibers dispersed in the air. Finally, we established a series of numerical analysis methods that enable precise prediction of asbestos fiber deposition and heterogeneous hot-spot distributions in the airways.

Academic Significance and Societal Importance of the Research Achievements

本研究では,生理的アスベスト動態モデルと生体流体解析技術を統合した数値気道モデルを作成した上で,繊維形状であるアスベストの力学的特徴を正確に再現した浮遊アスベストの空気中輸送と沈着を解析するEuler-Lagrange型の数値解析技術を確立し,一連の統合シミュレーションモデルとして整理を行った.実人体を対象としたin vivo実験が困難なアスベスト曝露問題に対し,数値解析を基盤とした曝露予測手法を新たな視点で構築するもので,医―工連携課題としての学術的意義がある.

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (21 results)

All 2023 2022 2021 Other

All Int'l Joint Research (3 results) Journal Article (6 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 6 results,  Open Access: 1 results) Presentation (10 results) (of which Int'l Joint Research: 10 results,  Invited: 1 results) Remarks (2 results)

  • [Int'l Joint Research] 豪州RMIT大学/豪州ADRI(オーストラリア)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] ADRI/RMIT University(オーストラリア)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] ADRI(オーストラリア)

    • Related Report
      2020 Research-status Report
  • [Journal Article] Coupled Eulerian Wall Film?Discrete Phase model for predicting respiratory droplet generation during a coughing event2023

    • Author(s)
      Khoa Nguyen Dang、Kuga Kazuki、Inthavong Kiao、Ito Kazuhide
    • Journal Title

      Physics of Fluids

      Volume: 35 Issue: 11 Pages: 0-0

    • DOI

      10.1063/5.0174014

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A pilot numerical study of odorant transport to the olfactory region during sensory evaluations following ISO 16000-282023

    • Author(s)
      Kuga Kazuki、Hoshiyama Sara、Wargocki Pawel、Ito Kazuhide
    • Journal Title

      Building and Environment

      Volume: 245 Pages: 110868-110868

    • DOI

      10.1016/j.buildenv.2023.110868

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Computational fluid-particle dynamics modeling of ultrafine to coarse particles deposition in the human respiratory system, down to the terminal bronchiole2023

    • Author(s)
      Khoa Nguyen Dang、Li Sixiao、Phuong Nguyen Lu、Kuga Kazuki、Yabuuchi Hidetake、Kan-O Keiko、Matsumoto Koichiro、Ito Kazuhide
    • Journal Title

      Computer Methods and Programs in Biomedicine

      Volume: 237 Pages: 107589-107589

    • DOI

      10.1016/j.cmpb.2023.107589

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Transport and deposition of inhaled man‐made vitreous and asbestos fibers in realistic human respiratory tract models: An in silico study2022

    • Author(s)
      Dang Khoa Nguyen、Phuong Nguyen Lu、Takahashi Ken、Ito Kazuhide
    • Journal Title

      JAPAN ARCHITECTURAL REVIEW

      Volume: 5 Issue: 4 Pages: 592-608

    • DOI

      10.1002/2475-8876.12277

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prediction of exhaled carbon dioxide concentration using a computer‐simulated person that included alveolar gas exchange2022

    • Author(s)
      Kuga Kazuki、Sakamoto Mitsuharu、Wargocki Pawel、Ito Kazuhide
    • Journal Title

      Indoor Air

      Volume: 32 Issue: 8 Pages: 13079-13079

    • DOI

      10.1111/ina.13079

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Breathing zone and exhaled air re‐inhalation rate under transient conditions assessed with a computer‐simulated person2022

    • Author(s)
      Kuga Kazuki、Wargocki Pawel、Ito Kazuhide
    • Journal Title

      Indoor Air

      Volume: 32 Issue: 2 Pages: 13003-13003

    • DOI

      10.1111/ina.13003

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Computational Fluid Dynamics Modeling for Repeated Inhalation Exposure Assessment with OpenFOAM2023

    • Author(s)
      K. Yokoo, S. Tanaka, M. Niwano, Y. Matoba, K. Kuga, S. Yoo, K. Ito
    • Organizer
      SETAC North America 44th Annual Meeting
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Numerical Predition of Respiratory Droplet Generation from Coughing Using Discrete phase-coupled Eulerian Wall Film Model2023

    • Author(s)
      Nguyen Dang Khoa, Kazuki Kuga, Kazuhide Ito
    • Organizer
      ICNAA 2023, Brisbane, Australia
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In Silico airway model study for developing artificial lung ventilator using endotracheal tube2023

    • Author(s)
      Sixiao Li, Nguyen Dang Khoa, Kazuhide Ito
    • Organizer
      IAQVEC 2023, Tokyo
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Large Eddy Simulation of Airflow Patterns in the Human Upper and Lower Airway Up To the 16th Generation: A Comparison Study2023

    • Author(s)
      Nguyen Dang Khoa, Nguyen Lu Phuong, Kazuhide Ito.
    • Organizer
      Healthy Building 2023 Asia Pacific, China
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Computational analysis of ultrafine and fine particle deposition mechanisms in human lower airway2022

    • Author(s)
      Nguyen Dang Khoa, Kazuhide Ito
    • Organizer
      ACFD 2022, South Korea, October 16-19
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Numerical Investigation of Fine particle Transportation and Deposition in the Human Lower Airway: Impact of airflow and particle size on deposition efficiency2022

    • Author(s)
      Nguyen Dang Khoa, Nguyen Lu Phuong, Kazuhide Ito
    • Organizer
      IEICES 2022, IGSES, Kyushu University
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Regional deposition characteristics of fibrous particles compared to spherical particles in human upper airway - in silico case study2022

    • Author(s)
      Nguyen Dang Khoa, Kazuhide Ito
    • Organizer
      IEICES 2022, IGSES, Kyushu University
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Computational Fluid Dynamics Application to Investigate Man-Made Vitreous Fibers Transporation and deposition in Realistic Human Respiratory System2021

    • Author(s)
      Nguyen Dang Khoa, Nguyen Lu Phuong, Ken Takahashi, Kazuhide Ito
    • Organizer
      Healthy Building America, 2021, Hawaii, USA,
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] In Silico Human Model based Indoor Design for Healthy Environment2021

    • Author(s)
      Kazuhide Ito
    • Organizer
      2021 International Conference of Green Building and Low Carbon Technology, China, 2021, Xi'an University of Architecture and Technology
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Computational Fluid Dynamics Application to Investigate Man-Made Vitreous Fibers Transporation and deposition in Realistic Human Respiratory System2021

    • Author(s)
      Nguyen Dang Khoa, Nguyen Lu Phuong, Ken Takahashi, Kazuhide Ito
    • Organizer
      Healthy Building America, 2021, Hawaii, USA
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Remarks] 九州大学 伊藤一秀研究室

    • URL

      http://www.phe-kyudai.jp

    • Related Report
      2023 Annual Research Report 2022 Research-status Report 2021 Research-status Report
  • [Remarks] 九州大学 伊藤一秀研究室

    • Related Report
      2020 Research-status Report

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Published: 2020-10-29   Modified: 2025-01-30  

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