Atmospheric behavior and health effect of polycyclic aromatic compounds formed via reactions on Asian dust surface

• Project/Area Number: 21200031
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
• Allocation Type: Single-year Grants
• Research Field: Risk sciences of radiation/Chemicals; Environmental pharmacy
• Research Institution: Kanazawa University
• Principal Investigator: KAMEDA Takayuki 金沢大学, 薬学系, 助教 (50398426)
• Co-Investigator(Renkei-kenkyūsha): HAYAKAWA Kazuichi 金沢大学, 薬学系, 教授 (40115267) ; TORIBA Akira 金沢大学, 薬学系, 准教授 (50313680) ; TANG Ning 兵庫医科大学, 医学部, 助教 (90372490)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥30,680,000 (Direct Cost: ¥23,600,000、Indirect Cost: ¥7,080,000); Fiscal Year 2011: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000); Fiscal Year 2010: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000); Fiscal Year 2009: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
• Keywords: 黄砂 / PAH / 越境大気汚染 / 健康影響

Research Abstract

The aim of this study is to elucidate atmospheric formation of toxic polycyclic aromatic hydrocarbons (PAH) derivatives on the surface of Asian dust particles transported from the Asian Continent to Japan and to evaluate adverse health effects induced by the compounds. We performed chemical reaction experiments of PAHs on the Asian dust particle surface using a reaction-chamber, and investigated the formation of substituted PAHs on the particles.

Research Products

• [Journal Article] Atmospheric formation of hydroxynitrofluoranthene from photo chemical reactions of 2-nitrofluoranthene (2012)
  • Author(s): T. Kameda, A. Akiyama, A. Toriba, N. Tang, K. Hayakawa
  • Journal Title: Polycyclic Aromat. Compd. Volume: (in press) Issue: 2 Pages: 177-187
  • DOI: 10.1080/10406638.2011.654307
  • Peer Reviewed
• [Journal Article] Determination of Benzo[a]pyrene-7, 10-quinone in Airborne Particulates by Using a Chemiluminescence Reaction of Hydrogen Peroxide and Hydrosulfite (2012)
  • Author(s): R. Li, T. Kameda, Y. Li, A. Toriba, N. Tang, K. Hayakawa, J.-M. Lin
  • Journal Title: Anal. Chem. Volume: 84 Issue: 7 Pages: 3215-3221
  • DOI: 10.1021/ac2032063
  • Peer Reviewed
• [Journal Article] Atmospheric formation of hydroxynitrofluoranthene from photochemical reactions of 2-nitrofluoranthene (2012)
  • Author(s): T.Kameda
  • Journal Title: Polycyclic Aromat.Compd. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Hydrogen peroxide-sodium hydrosulfite chemiluminescence system combined with high-performance liquid chromatography for determination of 1-hydroxypyrene in airborne particulates (2011)
  • Author(s): R. Li, T. Kameda, Y. Li, A. Toriba, N. Tang, K. Hayakawa, J.-M. Lin
  • Journal Title: Talanta Volume: 85 Issue: 5 Pages: 2711-2714
  • DOI: 10.1016/j.talanta.2011.08.005
  • Peer Reviewed
• [Journal Article] Atmospheric formation of hydroxynitropyrenes from a photochemical reaction of particle-associated 1-nitropyrene (2011)
  • Author(s): T. Kameda, A. Akiyama, A. Toriba, N. Tang, K. Hayakawa
  • Journal Title: Environ. Sci. Technol. Volume: 45 Issue: 8 Pages: 3325-3332
  • DOI: 10.1021/es1042172
  • Peer Reviewed
• [Journal Article] Atmospheric Chemistry of Polycyclic Aromatic Hydrocarbons and Related Compounds (2011)
  • Author(s): T. Kameda
  • Journal Title: Journal of Health Science Volume: 57 Issue: 6 Pages: 504-511
  • DOI: 10.1248/jhs.57.504
  • NAID: 130001869867
  • ISSN: 1344-9702, 1347-5207
  • Peer Reviewed
• [Journal Article] Mutagenicities and Endocrine-disrupting Activities of 1-Hydroxy-2-nitropyrene and 1-Hydroxy-5-nitropyrene (2011)
  • Author(s): T. Kameda, A. Akiyama, M. Yoshita, C. Tachikawa, A. Toriba, N. Tang, K. Hayakawa
  • Journal Title: Journal of Health Science Volume: 57 Issue: 4 Pages: 372-377
  • DOI: 10.1248/jhs.57.372
  • NAID: 130001001083
  • ISSN: 1344-9702, 1347-5207
  • Peer Reviewed
• [Journal Article] Recent Changes in Atmospheric Polycyclic Aromatic Hydrocarbons and Nitropoly cyclic Aromatic Hydrocarbons in Shenyang, China (2011)
  • Author(s): N.Tang
  • Journal Title: Environmental Forensics Volume: 12 Issue: 4 Pages: 342-348
  • DOI: 10.1080/15275922.2011.622347
  • Peer Reviewed
• [Journal Article] Atmospheric concentrations of polycyclic aromatic hydrocarbons and selected nitrated derivatives in Greater Cairo, Egypt (2011)
  • Author(s): H.F.Nassar
  • Journal Title: Atmos.Environ. Volume: 39 Issue: 39 Pages: 7352-7359
  • DOI: 10.1016/j.atmosenv.2011.07.043
  • Peer Reviewed
• [Journal Article] Estrogenic/Antiestrogenic Activities of Quinoid Polycyclic Aromatic Hydrocarbons (2011)
  • Author(s): K.Hayakawa
  • Journal Title: Journal of Health Science Volume: 57 Issue: 3 Pages: 274-280
  • DOI: 10.1248/jhs.57.274
  • NAID: 130000800088
  • ISSN: 1344-9702, 1347-5207
  • Peer Reviewed
• [Journal Article] Development of HPLC determination method for trace levels of 1-,2-nitropyrenes and 2-nitrofluoranthene in airborne particulates and its application to samples collected at Noto Peninsula (2011)
  • Author(s): K.Hayakawa
  • Journal Title: Asian J.Atmos.Environ. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Atmospheric formation of hydroxynitropyrenes from a photochemical reaction of particle-associated 1-nitropyrene (2011)
  • Author(s): T.Kameda
  • Journal Title: Environ.Sci.Technol. Volume: (in press)
  • Peer Reviewed
• [Journal Article] 中国・北京及び日本・金沢の大気が示すAhR活性化作用へのPAH類及びダイオキシン類の寄与 (2011)
  • Author(s): 戸次加奈江
  • Journal Title: 環境化学 Volume: 21 Pages: 27-33
  • Peer Reviewed
• [Journal Article] 日本および中国における大気粒子中多環芳香族炭化水素キノンの観測-濃度レベルの把握と発生要因の検討- (2011)
  • Author(s): 片山裕規
  • Journal Title: 大気環境学会誌 Volume: 46 Pages: 20-29
  • Peer Reviewed
• [Journal Article] Determination of particle-associated hydroxynitropyrenes with correction for chemical degradation on a quartz fiber filter during high volume air sampling (2010)
  • Author(s): T. Kameda, A. Akiyama, A. Toriba, N. Tang, K. Hayakawa
  • Journal Title: Intern. J. Environ. Anal. Chem. Volume: 90 Issue: 13 Pages: 976-987
  • DOI: 10.1080/03067310903359484
  • Peer Reviewed
• [Journal Article] Determination of particle-associated hydroxynitropyrenes with correction for chemical degradation on a quartz fiber filter during high volume air sampling (2010)
  • Author(s): T.Kameda
  • Journal Title: Int.J.Environ.Anal.Chem. Volume: 90 Pages: 976-987
  • Peer Reviewed
• [Journal Article] GC-MSを用いた大気中多環芳香族炭化水素酸化物の分析法開発に関する基礎的検討 (2010)
  • Author(s): 岸田真男
  • Journal Title: 環境化学 Volume: 20 Pages: 173-181
  • Peer Reviewed
• [Journal Article] Determination of particle-associated hydroxynitropyrenes with correction for chemical degradation on a quartz fiber filter during high volume air sampling (2010)
  • Author(s): T.Kameda
  • Journal Title: Int. J.Environ. Anal. Chem. (in press)
  • Peer Reviewed
• [Journal Article] Indirect- and direct-acting mutagenicity of diesel, coal and wood burning-derived particulates and contribution of polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons (2010)
  • Author(s): X.Yang
  • Journal Title: Mutat. Res. 695 Pages: 29-34
  • Peer Reviewed
• [Journal Article] Determination of airborne particle-associated benz[a]anthracene-7,12-quinone using high-performance liquid chromatography with in-line reduction and fluorescence detection (2009)
  • Author(s): T. Kameda, T. Goto, A. Toriba, N. Tang, K. Hayakawa
  • Journal Title: J. Chromatogr. A Volume: 1216 Issue: 39 Pages: 6758-6761
  • DOI: 10.1016/j.chroma.2009.08.009
  • Peer Reviewed
• [Journal Article] Determination of airborne particle-associated benz[a]anthracene-7,12-quinone using high-performance liquid chromatography with in-line reduction and fluorescence detection (2009)
  • Author(s): T.Kameda
  • Journal Title: J.Chromatogr. A 1216 Pages: 6758-6761
  • Peer Reviewed
• [Journal Article] Determination of 1-nitropyrene in low volume ambient air samples by high-performance liquid chromatography with fluorescence detection (2009)
  • Author(s): T.Ohno
  • Journal Title: J.Chromatogr. A 1216 Pages: 4625-4628
  • Peer Reviewed
• [Journal Article] Oxidative Stress More Strongly Induced by ortho- Than para-quinoid Polycyclic Aromatic Hydrocarbons in A549 Cells (2009)
  • Author(s): Y.Motoyama
  • Journal Title: J.Health Sci. 55 Pages: 845-850
  • Peer Reviewed
• [Journal Article] Monohydroxylated polycyclic aromatic hydrocarbons inhibit both osteoclastic and osteoblastic activities in teleost scales (2009)
  • Author(s): N.Suzuki
  • Journal Title: Life Sci. 84 Pages: 482-488
  • Peer Reviewed
• [Journal Article] Distribution and source of atmospheric polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons in Tieling City, Liaoning Province, a typical local city in northeast China (2009)
  • Author(s): N.Tang
  • Journal Title: Asian Journal of Atmospheric Environment 3 Pages: 52-58
  • Peer Reviewed
• [Journal Article] Long-range transport of fluoride in East Asia monitored at Noto Peninsula, Japan (2009)
  • Author(s): X.Yang
  • Journal Title: Sci. Total Environ. 407 Pages: 4681-4686
  • Peer Reviewed
• [Presentation] 越境輸送中の黄砂粒子表面におけるニトロ化多環芳香族炭化水素の二次生成 (2011)
  • Author(s): 亀田貴之, 安積愛理, 松木篤, 唐寧, 福島杏希, 鳥羽陽, 早川和一
  • Organizer: 第52回大気環境学会年会
  • Place of Presentation: 長崎大学(長崎県)
  • Year and Date: 2011-09-14
• [Presentation] 黄砂粒子表面における多環芳香族炭化水素キノンの二次生成と越境輸送 (2011)
  • Author(s): 片山裕規
  • Organizer: 第52回大気環境学会年会
  • Place of Presentation: 長崎大学(長崎県)
  • Year and Date: 2011-09-14
• [Presentation] Atmospheric formation of hydroxynitrofluoranthene from a photochemical reaction of particle-associated 2-nitrofluoranthene (2011)
  • Author(s): T.Kameda
  • Organizer: International Society For Polycyclic Aromatic Compounds (ISPAC) 23
  • Place of Presentation: University of Munster (Germany)
  • Year and Date: 2011-09-05
• [Presentation] Atmospheric occurrence of particle-associated nitrotriphenylenes via gas-phase radical-initiated reactions in Southern Osaka, Japan (2011)
  • Author(s): T.Kameda
  • Organizer: International Society For Polycyclic Aromatic Compounds (ISPAC) 23
  • Place of Presentation: University of Munster (Germany)
  • Year and Date: 2011-09-05
• [Presentation] Identification and quantification of the urinary metabolites of 9,10-phenanthrenequinone associated with producing reactive oxygen species (2011)
  • Author(s): T.Kameda
  • Organizer: International Society For Polycyclic Aromatic Compounds (ISPAC) 23
  • Place of Presentation: University of Munster (Germany)
  • Year and Date: 2011-09-05
• [Presentation] Determination of hydroxyl substituted polycyclic aromatic hydrocarbon in airborne particles using gas chromatography/tandem mass spectrometry (2011)
  • Author(s): K.Bekki
  • Organizer: International Society For Polycyclic Aromatic Compounds (ISPAC) 23
  • Place of Presentation: University of Munster (Germany)
  • Year and Date: 2011-09-05
• [Presentation] Behaviors of polycyclic aromatic hydrocarbons and nitropolycyclic aromatic hydrocarbons in airborne particulates of Hanoi capital-Vietnam (2011)
  • Author(s): P.C.Thuy
  • Organizer: International Society For Polycyclic Aromatic Compounds (ISPAC) 23
  • Place of Presentation: University of Munster (Germany)
  • Year and Date: 2011-09-05
• [Presentation] 黄砂粒子表面における多環芳香族炭化水素のニトロ化と越境輸送 (2011)
  • Author(s): 亀田貴之, 安積愛理, 唐寧, 松木篤, 福島杏希, 鳥羽陽, 早川和一
  • Organizer: 第20回環境化学討論会
  • Place of Presentation: 熊本県立大学(熊本県)
  • Year and Date: 2011-07-14
• [Presentation] 環境中の多環芳香族炭化水素および細菌の除去を目的とした機能性繊維の開発及び評価 (2011)
  • Author(s): 山田丸
  • Organizer: 第20回環境化学討論会
  • Place of Presentation: 熊本県立大学(熊本県)
  • Year and Date: 2011-07-14
• [Presentation] 活性酸素種を生成する多環芳香族炭化水素キノン誘導体のヒト尿中代謝物の同定と定量 (2011)
  • Author(s): 旭美樹
  • Organizer: 第20回環境化学討論会
  • Place of Presentation: 熊本県立大学(熊本県)
  • Year and Date: 2011-07-14
• [Presentation] 越境輸送中の黄砂粒子表面におけるニトロ化多環芳香族炭化水素の二次生成 (2011)
  • Author(s): 亀田貴之, 安積愛理, 松木篤, 唐寧, 鳥羽陽, 早川和一
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡県立大学, ほか(静岡県)
  • Year and Date: 2011-03-28
• [Presentation] 越境輸送中の黄砂粒子表面におけるニトロ化多環芳香族炭化水素の二次生成 (2011)
  • Author(s): 亀田貴之
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: (東日本大震災のため誌上開催)
• [Presentation] 黄砂粒子表面における多環芳香族炭化水素のニトロ化と越境大気汚染の可能性 (2011)
  • Author(s): 亀田貴之
  • Organizer: 第2回能登総合シンポジウム
  • Place of Presentation: 珠洲市商工会議所(石川県)
• [Presentation] 越境輸送中の黄砂粒子表面におけるニトロ化多環芳香族炭化水素の二次生成 (2010)
  • Author(s): 安積愛理
  • Organizer: 平成22年度大気環境学会中部支部総会・学術集会
  • Place of Presentation: 岐阜市文化産業交流センター(岐阜県)
  • Year and Date: 2010-11-27
• [Presentation] 黄砂粒子表面における多環芳香族炭化水素のニトロ化と越境大気汚染の可能性 (2010)
  • Author(s): 安積愛理, 亀田貴之, 松木篤, 唐寧, 鳥羽陽, 早川和一
  • Organizer: 第51回大気環境学会年会
  • Place of Presentation: 大阪大学(大阪府)
  • Year and Date: 2010-09-08
• [Presentation] 日本および中国における大気粒子中多環芳香族炭化水素キノンの観測:濃度レベルの把握と発生要因の検討 (2010)
  • Author(s): 亀田貴之, 後藤知子, 鳥羽陽, 唐寧, 早川和一
  • Organizer: 第19回環境化学討論会
  • Place of Presentation: 中部大学(愛知県)
  • Year and Date: 2010-06-21
• [Presentation] 環境中で非意図的に生成する有害化学物質-多環芳香族炭化水素誘導体の大気内二次生成- (2010)
  • Author(s): 亀田貴之
  • Organizer: 第29回金沢大学公衆衛生学研究会
  • Place of Presentation: 金沢大学(石川県)(招待講演)
  • Year and Date: 2010-06-10
• [Presentation] 大気粒子状物質に含まれる多環芳香族炭化水素キノン類の測定 (2010)
  • Author(s): 亀田貴之
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山大学ほか(岡山県)
  • Year and Date: 2010-03-30
• [Presentation] 日本および中国における大気粒子中多環芳香族炭化水素キノン濃度の測定:汚染レベルの比較ならびに発生要因の検討 (2010)
  • Author(s): 片山裕規
  • Organizer: 第51回大気環境学会年会
  • Place of Presentation: 大阪大学(大阪府)
• [Presentation] 多環芳香族炭化水素類の越境輸送解析 (2010)
  • Author(s): 亀田貴之
  • Organizer: 第51回大気環境学会年会
  • Place of Presentation: 大阪大学(大阪府)(招待講演)
• [Presentation] 越境輸送中の黄砂粒子表面における多環芳香族炭化水素ニトロ化の可能性 (2010)
  • Author(s): 安積愛理
  • Organizer: 第19回環境化学討論会
  • Place of Presentation: 中部大学(愛知県)
• [Presentation] 実大気粒子中多環芳香族炭化水素キノン類の観測 (2009)
  • Author(s): 後藤知子
  • Organizer: 大気環境学会中部支部総会・学術集会
  • Place of Presentation: 金沢勤労者プラザ(石川県)
  • Year and Date: 2009-12-12
• [Presentation] 黄砂表面における有害有機化学物質の非意図的生成と越境輸送の可能性 (2009)
  • Author(s): 亀田貴之
  • Organizer: 第1回能登総合シンポジウム
  • Place of Presentation: 珠洲市商工会議所(石川県)
  • Year and Date: 2009-11-30
• [Presentation] Determination of airborne particle-associated hydroxynitropyrenes formed viaatmospheric photochemical reactions (2009)
  • Author(s): T.Kameda
  • Organizer: Asia and Africa Science Platform Program International Seminar "Environment and Health"
  • Place of Presentation: 第4高等学校記念文化交流館(石川県)
  • Year and Date: 2009-10-30
• [Presentation] 黄砂表面における有害有機化学物質の非意図的生成と越境輸送の可能性 (2009)
  • Author(s): 亀田貴之
  • Organizer: 第3回環日本海域環境シンポジウム
  • Place of Presentation: 第4高等学校記念文化交流館(石川県)
  • Year and Date: 2009-10-29
• [Presentation] Determination of airborne particle-associated hydroxynitropyrenes formed viaatmospheric photochemical reactions (2009)
  • Author(s): T.Kameda
  • Organizer: International Society For Polycyclic Aromatic Compounds(ISPAC)22
  • Place of Presentation: Francis Marion Hotel(USA)
  • Year and Date: 2009-09-23
• [Presentation] 光反応により生成する大気粒子中新奇ニトロピレン水酸化体の同定および定量 (2009)
  • Author(s): 亀田貴之, 秋山鮎子, 鳥羽陽, 唐寧, 早川和一
  • Organizer: 第50回大気環境学会年会
  • Place of Presentation: 慶應義塾大学(神奈川県)
  • Year and Date: 2009-09-16
• [Presentation] 大気内光反応により生成する新奇ニトロピレン水酸化体の同定および定量 (2009)
  • Author(s): 亀田貴之
  • Organizer: 第18回環境化学討論会
  • Place of Presentation: つくば国際会議場(茨城県)
  • Year and Date: 2009-06-09
• [Book] Water Pollution X (2010)
  • Author(s): K.Hayakawa
  • Total Pages: 384
  • Publisher: WIT Press
• [Book] Photochemical degradation of selected nitro-and oxy-polycyclic aromatic hydrocarbons on airborne particles under simulated solar UV-irradiation, Airborne Particulates, (Ming Cheng and Wen Liu, eds.) (2009)
  • Author(s): T. Kameda, Y. Nakayama, T. Goto, T. Koyanagi, H. Bandow, K. Fujimori, A. Toriba, N. Tang, K. Hayakawa
  • Publisher: Nova Science Publishers
• [Book] Airborne Particulates (2009)
  • Author(s): T.Kameda, et al.
  • Total Pages: 343
  • Publisher: Nova Sacience Publishiers
• [Patent(Industrial Property Rights)] 砂塵飛来有害物質及び微生物除去剤,砂塵飛来有害物質及び微生物除去セルロース繊維及び繊維構造物 (2011)
  • Inventor(s): 山田丸, 亀田貴之, ほか 6名
  • Industrial Property Rights Holder: 金沢大学, ダイワボウホールディングス(株), ダイワボウノイ(株)
  • Industrial Property Number: 2011-155806
  • Filing Date: 2011-07-14
• [Patent(Industrial Property Rights)] 砂塵飛来有害物質及び微生物除去剤、砂塵飛来有害物質及び微生物除去セルロース繊維及び繊維構造物 (2011)
  • Inventor(s): 山田丸, 亀田貴之, 早川和一, 岩坂泰信, 小林史尚, 松木篤, 築城寿長, 檜垣誠吾
  • Industrial Property Rights Holder: 金沢大学,ダイワボウホールディングス(株),ダイワボウノイ(株)
  • Industrial Property Number: 2011-155806
  • Filing Date: 2011-07-14
• [Patent(Industrial Property Rights)] 臭気成分捕集用繊維状吸着材 (2010)
  • Inventor(s): 斉藤満, ほか
  • Industrial Property Rights Holder: 日本フィルコン(株)
  • Industrial Property Number: 2010-173968
  • Filing Date: 2010-08-02
• [Patent(Industrial Property Rights)] 芳香族ニトロ化合物の製造方法 (2009)
  • Inventor(s): 亀田貴之, 松木篤
  • Industrial Property Rights Holder: 金沢大学
  • Industrial Property Number: 2009-246879
  • Filing Date: 2009-10-27