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Analyzing neuronal development through deciphering splicing code

Research Project

Project/Area Number 21249013
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field General pharmacology
Research InstitutionKyoto University (2010-2011)
Tokyo Medical and Dental University (2009)

Principal Investigator

HAGIWARA Masatoshi  京都大学, 大学院・医学研究科, 教授 (10208423)

Co-Investigator(Kenkyū-buntansha) OONO Kinji  名古屋大学, 医学(系)研究科(研究院), 教授 (80397455)
TAKEUCHI Akihide  京都大学, 医学(系)研究科(研究院), 准教授 (90436618)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥48,230,000 (Direct Cost: ¥37,100,000、Indirect Cost: ¥11,130,000)
Fiscal Year 2011: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2010: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2009: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Keywordsスプライシング / 大脳皮質形成 / エクソンアレイ / スプライシング調節因子 / プロファイリング解析 / 神経発生 / mRNA / 大脳皮質 / 発現パターン
Research Abstract

We could identified genome wide level of alternative splicing regulation regarding spliced genes and RNA-binding proteins during neuronal development.

Report

(5 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Products Report
  • Research Products

    (215 results)

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article (63 results) (of which Peer Reviewed: 36 results,  Open Access: 18 results,  Acknowledgement Compliant: 2 results) Presentation (142 results) (of which Invited: 8 results) Remarks (2 results) Patent(Industrial Property Rights) (8 results) (of which Overseas: 3 results)

  • [Journal Article] Loss of Sfpq causes long-gene transcriptopathy in the brain.2018

    • Author(s)
      Takeuchi A, Iida K, Tsubota T, Hosokawa M, Denawa M, Brown JB, Ninomiya K, Ito M, Kimura H, Abe T, Kiyonari H, Ohno K, and Hagiwara M
    • Journal Title

      Cell Reports.

      Volume: 23 Issue: 5 Pages: 1326-1341

    • NAID

      120006463742

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice2017

    • Author(s)
      Akiko Nakano-Kobayashi, Tomonari Awaya, Isao Kii, Yuto Sumida, Yukiko Okuno, Suguru Yoshida, Tomoe Sumida, Haruhisa Inoue, Takamitsu Hosoya and Masatoshi Hagiwara
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of america

      Volume: 114 Issue: 38 Pages: 10268-10273

    • DOI

      10.1073/pnas.1704143114

    • NAID

      130007900113

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] RBM24 promotes U1 snRNP recognition of the mutated 5′ splice site in the IKBKAP gene of familial dysautonomia2017

    • Author(s)
      Ohe Kenji、Yoshida Mayumi、Nakano-Kobayashi Akiko、Hosokawa Motoyasu、Sako Yukiya、Sakuma Maki、Okuno Yukiko、Usui Tomomi、Ninomiya Kensuke、Nojima Takayuki、Kataoka Naoyuki、Hagiwara Masatoshi
    • Journal Title

      RNA

      Volume: 23 Issue: 9 Pages: 1393-1403

    • DOI

      10.1261/rna.059428.116

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate.2017

    • Author(s)
      Ohta H, Kurimoto K, Okamoto I, Nakamura T, Yabuta Y, Miyauchi H, Yamamoto T, Okuno Y, Hagiwara M, Shirane K, Sasaki H, Saitou M
    • Journal Title

      EMBO J

      Volume: 36 Issue: 13 Pages: 1888-1907

    • DOI

      10.15252/embj.201695862

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy2017

    • Author(s)
      Sako Yukiya、Ninomiya Kensuke、Okuno Yukiko、Toyomoto Masayasu、Nishida Atsushi、Koike Yuka、Ohe Kenji、Kii Isao、Yoshida Suguru、Hashimoto Naohiro、Hosoya Takamitsu、Matsuo Masafumi、Hagiwara Masatoshi
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 46126-46126

    • DOI

      10.1038/srep46126

    • NAID

      120006355767

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] Selective inhibition of the kinase DYRK1A by targeting its folding process2016

    • Author(s)
      Kii I., Sumida Y., Goto T., Sonamoto R., Okuno Y., Yoshida S., Kato-Sumida T., Koike Y., Abe M., Nonaka Y., Ikura T., Ito N., Shibuya H., Hosoya T., Hagiwara M.
    • Journal Title

      Nat. Commun.

      Volume: 該当なし Issue: 1 Pages: 11391-11391

    • DOI

      10.1038/ncomms11391

    • NAID

      120005770755

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] 家族性自律神経失調症の治療薬候補2016

    • Author(s)
      大江賢治、萩原正敏
    • Journal Title

      医学のあゆみ

      Volume: 257 Issue: 4 Pages: 318-319

    • Related Report
      Products Report
  • [Journal Article] ケミカルバイオロジーから創薬へ2016

    • Author(s)
      萩原正敏
    • Journal Title

      現代化学

      Volume: 541 Pages: 28-30

    • Related Report
      Products Report
  • [Journal Article] Deciphering targeting rules of splicing modulator compounds: case of TG003.2015

    • Author(s)
      Sakuma M, Iida K, Hagiwara M
    • Journal Title

      BMC Mol Biol.

      Volume: 16 Issue: 1 Pages: 16-16

    • DOI

      10.1186/s12867-015-0044-6

    • NAID

      120005758276

    • Related Report
      Products Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ2015

    • Author(s)
      Sonamoto R, Kii I, Koike Y, Sumida Y, Kato-Sumida T, Okuno Y, Hosoya T, and Hagiwara M
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 1-86

    • DOI

      10.1038/srep12728

    • NAID

      120005820881

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis.2015

    • Author(s)
      Masaki S, Kii I, Sumida Y, Kato-Sumida, Ogawa Y, Ito N, Nakamura M, Sonamoto R, Kataoka N , Hosoya T, and Hagiwara M
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 23 Issue: 15 Pages: 4434-4441

    • DOI

      10.1016/j.bmc.2015.06.018

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of a Dual Inhibitor of SRPK1 and CK2 that Attenuates Pathological Angiogenesis of Macular Degeneration in Mice.2015

    • Author(s)
      Satoshi Morooka, Mitsuteru Hoshina, Isao Kii, et al.
    • Journal Title

      Molecular Pharmacology

      Volume: 88 Issue: 2 Pages: 316-325

    • DOI

      10.1124/mol.114.097345

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia.2015

    • Author(s)
      Yoshida M, Kataoka N, Miyauchi K, Ohe K, Iida K, Yoshida S, Nojima T, Okuno Y, Onogi H, Usui T, Takeuchi A, Hosoya T, Suzuki T, Hagiwara M.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 112(9) Issue: 9 Pages: 2764-2769

    • DOI

      10.1073/pnas.1415525112

    • Related Report
      Products Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 次世代抗ウイルス薬の開発2015

    • Author(s)
      山本誠、萩原正敏
    • Journal Title

      感染・炎症・免疫

      Volume: 45 Issue: 1

    • Related Report
      Products Report
  • [Journal Article] 選択的スプライシング・ネットワークを化合物で操作する。Controlling the alternative splicing network with compounds2015

    • Author(s)
      大江賢治、萩原正敏
    • Journal Title

      生体の科学

      Volume: 66 Issue: 2 Pages: 114-118

    • Related Report
      Products Report
  • [Journal Article] RBFOX and SUP-12 sandwich a guanine base to form a stable complex and regulate tissue-specific splicing.2014

    • Author(s)
      Kuwasako K, Takahashi M, Unzai S, Tsuda K, Yoshikawa S, He F, Kobayashi N, Guntert P, Shirouzu M, Ito T, Tanaka A, Yokoyama S, Hagiwara M, Kuroyanagi H, and Muto Y.
    • Journal Title

      Nat. Struct. Mol. Biol.

      Volume: 21(9) Issue: 9 Pages: 778-86

    • DOI

      10.1038/nsmb.2870

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] RNA病2014

    • Author(s)
      木村亮、萩原正敏
    • Journal Title

      分子精神医学

      Volume: 114 Issue: 2 Pages: 62-63

    • Related Report
      Products Report
  • [Journal Article] 選択的スプライシングを標的とした低分子化合物の医薬品開発2014

    • Author(s)
      大江賢治、萩原正敏
    • Journal Title

      BIO Clinica BIOLOGYTOPICS

      Volume: 3 Pages: 95-99

    • Related Report
      Products Report
  • [Journal Article] キナーゼの多彩な立体構造を標的とした創薬2014

    • Author(s)
      喜井勲、萩原正敏
    • Journal Title

      実験医学

      Volume: 32 Issue: 2 Pages: 133-139

    • Related Report
      Products Report
  • [Journal Article] CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans.2013

    • Author(s)
      Kuroyanagi H, Watanabe Y, and Hagiwara M.
    • Journal Title

      PLoS Genet

      Volume: 9(2)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Position-dependent and neuron-specific splicing regulation by the CELF family RNA-binding protein UNC-75 in Caenorhabditis elegans2013

    • Author(s)
      Kuroyanagi H, Watanabe Y, Suzuki Y, Hagiwara M
    • Journal Title

      Nucleic Acids Research

      Volume: 41 Issue: 7 Pages: 4015-4025

    • DOI

      10.1093/nar/gkt097

    • Related Report
      2011 Annual Research Report Products Report
    • Peer Reviewed
  • [Journal Article] CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans2013

    • Author(s)
      Kuroyanagi H, Watanabe Y, Hagiwara M
    • Journal Title

      PLoS Genetics

      Volume: 9 Issue: 2 Pages: e1003337-e1003337

    • DOI

      10.1371/journal.pgen.1003337

    • Related Report
      2011 Annual Research Report Products Report
    • Peer Reviewed
  • [Journal Article] Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD.2013

    • Author(s)
      Gammons MV, Fedorov O, Ivison D, Du C, Clark T, Hopkins C, Hagiwara M, Dick AD, Cox R, Harper SJ, Hancox JC, Knapp S, Bates DO.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 54(9) Issue: 9 Pages: 6052-6062

    • DOI

      10.1167/iovs.13-12422

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth2013

    • Author(s)
      Pozo N, Zahonero C, Fernández P, Liñares JM, Ayuso A, Hagiwara M, Pérez A, Ricoy JR, Hernández-Laín A, Sepúlveda JM, Sánchez-Gómez P.
    • Journal Title

      J Clin Invest.

      Volume: 123(6) Issue: 6 Pages: 2475-2487

    • DOI

      10.1172/jci63623

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization.2013

    • Author(s)
      Dong Z, Noda K, Kanda A, Fukuhara J, Ando R, Murata M, Saito W, Hagiwara M, Ishida S
    • Journal Title

      Mol Vis.

      Volume: 19 Pages: 536-543

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] hDbr1 is a nucleocytoplasmic shuttling protein with a protein phosphatase-like motif essential for debranching activity2013

    • Author(s)
      Kataoka, N. Hagiwara, M. and Ohno, M
    • Journal Title

      Sci. Rep

      Volume: 3-1090 Issue: 1 Pages: 1090-1090

    • DOI

      10.1038/srep01090

    • NAID

      120005241441

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] 可視化スプライシング・レポーターシステムで開く哺乳類の mRNA 制御の世界2012

    • Author(s)
      武内章英、萩原正敏
    • Journal Title

      細胞工学

      Volume: VOl.31 No.6

    • NAID

      40019333323

    • Related Report
      2011 Final Research Report
  • [Journal Article] RNA を標的とした新しい創薬戦略2012

    • Author(s)
      萩原正敏、片岡直行
    • Journal Title

      実験医学2012 増刊疾患克服をめざしたケミカルバイオロジー

      Pages: 46-52

    • Related Report
      2011 Final Research Report
  • [Journal Article] Muscle - specific splicing factors ASD - 2 and SUP - 12 cooperatively switch alternative pre - mRNA processing patterns of the ADF/cofilin gene in C. elegans .2012

    • Author(s)
      Ohno G , Ono K , Togo M , Watanabe Y , Ono S ,Hagiwara M , Kuroyanagi H
    • Journal Title

      PLoS Genet

      Volume: 8(10)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Challenges to congenital genetic disorders with "RNA-targeting" chemical compounds.2012

    • Author(s)
      Ogawa Y, Hagiwara M.
    • Journal Title

      Pharmacol Ther.

      Volume: 134(3) Issue: 3 Pages: 298-305

    • DOI

      10.1016/j.pharmthera.2012.02.001

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Muscle-Specific Splicing Factors ASD-2 and SUP-12 Cooperatively Switch Alternative Pre-mRNA Processing Patterns of the ADF/Cofilin Gene in Caenorhabditis elegans2012

    • Author(s)
      Ohno G, Ono K, Togo M, Watanabe Y, Ono S, Hagiwara M, Kuroyanagi H
    • Journal Title

      PLoS Genetics

      Volume: 8 Issue: 10 Pages: e1002991-e1002991

    • DOI

      10.1371/journal.pgen.1002991

    • Related Report
      2011 Annual Research Report Products Report
    • Peer Reviewed
  • [Journal Article] The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP22012

    • Author(s)
      Saitoh, N
    • Journal Title

      Mol.Biol.Cell

      Volume: 23 Issue: 6 Pages: 1115-1128

    • DOI

      10.1091/mbc.e11-09-0783

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication2012

    • Author(s)
      Kusano-Kitazume A, Sakamoto N, Okuno Y, Sekine-Osajima Y, Nakagawa M, Kakinuma S, Kiyonashi K, Nitta S, Murakawa M, Azuma S, Nishimura-Sakurai Y, Hagiwara M, Watanabe M
    • Journal Title

      Antimicrob Agent Chemother

      Volume: 56(3) Issue: 3 Pages: 1315-23

    • DOI

      10.1128/aac.05764-11

    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] 新しい構造生命科学の未来を拓くために何をなすべきか2012

    • Author(s)
      萩原正敏
    • Journal Title

      学術の動向

      Volume: 12 Pages: 46-61

    • Related Report
      Products Report
  • [Journal Article] cAMPシグナル2012

    • Author(s)
      萩原正敏
    • Journal Title

      シグナル伝達キーワード事典

      Pages: 53-54

    • Related Report
      Products Report
  • [Journal Article] 可視化スプライシング・レポーターシステムで開く哺乳類のmRNA制御の世界2012

    • Author(s)
      武内章英、萩原正敏
    • Journal Title

      細胞工学

      Volume: 31

    • NAID

      40019333323

    • Related Report
      Products Report
  • [Journal Article] RNAを標的とした新しい創薬戦略2012

    • Author(s)
      萩原正敏、片岡直行
    • Journal Title

      実験医学

      Pages: 46-52

    • Related Report
      Products Report
  • [Journal Article] Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor.2011

    • Author(s)
      Ninomiya K, Kataoka N, andHagiwara M.
    • Journal Title

      J Cell Biol.

      Volume: 195(1) Pages: 27-40

    • Related Report
      2011 Final Research Report
  • [Journal Article] Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.2011

    • Author(s)
      Debdab M, Carreaux F, Renault S, Soundararajan M, Fedorov O, Filippakopoulos P, Lozach O, Babault L, Tahtouh T, Baratte B, Ogawa Y, Hagiwara M, Eisenreich A, Rauch U, Knapp S, Meijer L, Bazureau JP
    • Journal Title

      J Med Chem.

      Volume: 54(12) Pages: 4172-4186

    • Related Report
      2011 Final Research Report
  • [Journal Article] Chemical treatment enhances skipping of a mutated exon in the dystrophin gene.2011

    • Author(s)
      Nishida A, Kataoka N, Takeshima Y, Yagi M, Awano, H, Ota, M, Itoh K, Hagiwara M, and Matsuo M
    • Journal Title

      Nature Commun

      Volume: 2 Pages: 308-308

    • NAID

      120003001398

    • Related Report
      2011 Final Research Report
  • [Journal Article] WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing2011

    • Author(s)
      Amin EM, Hua J, Cheung MK, Ni L, Kase S, Ren-nel ES, Gammons M, Nowak DG, Saleem MA, Hagiwara M, Schumacher VA, Harper SJ, Hinton D, Bates DO, Ladomery MR
    • Journal Title

      Cancer Cell

      Volume: 20 Pages: 768-780

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor2011

    • Author(s)
      Ninomiya K, Kataoka N, Hagiwara M
    • Journal Title

      J Cell Biol

      Volume: 195(1) Pages: 27-40

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Specific Y14 domains mediate its nucleo-cytoplasmic shuttling and association with spliced mRNA2011

    • Author(s)
      Kataoka N, Diem MD, Yoshida M, Hatai C, Dobashi I, Dreyfuss G, Hagiwara M, Ohno M
    • Journal Title

      Sci Rep

      Volume: 1:92

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B : modulation of alternative pre-RNA splicing2011

    • Author(s)
      Debdab M, Carreaux F, Renault S, Soundararajan M, Fedorov O, Filippakopoulos P, Lozach O, Babault L, Tahtouh T, Baratte B, Ogawa Y, Hagiwara M, Eisenreich A, Rauch U, Knapp S, Meijer L, Bazureau JP
    • Journal Title

      J Med Chem

      Volume: 54(12) Pages: 4172-4186

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical treatment enhances skipping of a mutated exon in the dystrophin gene2011

    • Author(s)
      Nishida A, Kataoka N, Takeshima Y, Yagi M, Awano, H, Ota, M, Itoh K, Hagiwara M, Matsuo M
    • Journal Title

      Nature communications

      Volume: 2:308

    • NAID

      120003001398

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNA pathologies in neurological disorders. Neurochemical Mechanisms in Disease, Advances in Neurobiology2011

    • Author(s)
      Ohno K, Masuda A
    • Journal Title

      (Ed by Abel Lajtha)(Springer, New York)

      Pages: 399-415

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Myasthenic syndrome caused by plectinopathy2011

    • Author(s)
      Selcen D, Juel VC, Hobson-Webb LD, Smith EC, Stickler DE, Bite AV, Ohno K, Engel AG
    • Journal Title

      Neurology

      Volume: 76 Pages: 327-336

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urinary 8-hydroxydeoxyguanosine correlate with hallucinations rather than motor symptoms in Parkinson's disease2011

    • Author(s)
      Hirayama M, Nakamura T, Watanabe H, Uchida K, Hama T, Hara T, Niimi Y, Ito M, Ohno K, Sobue G
    • Journal Title

      Parkinsonism Relat Disord

      Volume: 17 Pages: 46-49

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] スプライシング制御機構の解明とその臨床応用2010

    • Author(s)
      萩原正敏
    • Journal Title

      メディカル・サイエンス・ダイジェスト

      Volume: Vol.36, No.13 Pages: 2-3

    • Related Report
      2011 Final Research Report
  • [Journal Article] RNA スプライシングの可視化による創薬スクリーニング2010

    • Author(s)
      野島孝之、萩原正敏
    • Journal Title

      細胞工学

      Volume: Vol.29, No.02 Pages: 175-180

    • Related Report
      2011 Final Research Report
  • [Journal Article] RNA プロセシング異常RNA 病を斬る 基礎の基礎2010

    • Author(s)
      萩原正敏
    • Journal Title

      細胞工学

      Volume: Vol.29, No.02 Pages: 126-130

    • Related Report
      2011 Final Research Report
  • [Journal Article] Splicing reportermice revealed the evolutionally conserved switching mechanism of tissue-specific alternative splicing.2010

    • Author(s)
      Takeuchi A, Hosokawa M, Nojima T, Hagiwara M
    • Journal Title

      PLOS One

      Volume: 5

    • Related Report
      2011 Final Research Report
  • [Journal Article] Visualization and genetic analysis ofalternative splicing regulation in vivo using fluorescence reporters in transgenic Caenorhabditis elegans.2010

    • Author(s)
      Kuroyanagi H, Ohno G, Sakane, H, Maruoka, H, and Hagiwara M
    • Journal Title

      Nature Protoc.

      Volume: 5 Pages: 1495-1517

    • Related Report
      2011 Final Research Report
  • [Journal Article] Splicing reporter mice revealed the evolutionally conserved switching mechanism of tissue-specific alternative exon selection2010

    • Author(s)
      Takeuchi A, Hosokawa M, Nojima T, Hagiwara M
    • Journal Title

      PLoS One

      Volume: 3;5(6)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNAプロセシング異常:RNA病を斬る2010

    • Author(s)
      萩原正敏
    • Journal Title

      細胞工学

      Volume: 29(2) Pages: 126-130

    • Related Report
      2009 Annual Research Report
  • [Journal Article] mRNA スプライシング制御から難治疾患の治療へ2009

    • Author(s)
      萩原正敏
    • Journal Title

      実験医学

      Volume: Vol.27, No.17 Pages: 2870-2875

    • Related Report
      2011 Final Research Report
  • [Journal Article] Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing.2009

    • Author(s)
      Nojima T, Oshiro-Ideue T, Nakanoya H, Kawamura H, Morimoto M, Kawaguchi Y, Kataoka N and Hagiwara M
    • Journal Title

      Nucleic. Acids Res.

      Volume: 37 Pages: 6515-6527

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms-a novel therapeutic strategy for angiogenesis2009

    • Author(s)
      Nowak DG, Amin EM, Rennel ES, Hoareau-Aveilla C, Gammons M, Damodoran G, Hagiwara M, Harper SJ, Woolard J, Ladomery MR, Bates DO.
    • Journal Title

      J.Biol.Chem

      Volume: 285 Pages: 5532-5540

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing Nucleic.2009

    • Author(s)
      Nojima T, Oshiro-Ideue T, Nakanoya H, Kawamura H, Morimoto M, Kawaguchi Y, Kataoka N, Hagiwara M
    • Journal Title

      Acids Res

      Volume: 37(19) Pages: 6515-27

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCssII mRNA2009

    • Author(s)
      Jiang K, Patel NA, Watson JE, Apostolatos H, Kleiman E, Hanson O, Hagiwara M, Cooper DR.
    • Journal Title

      Endocrinology

      Volume: 150(5) Pages: 2087-97

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ウイルスによるスプライシング暗号の利用と撹乱2009

    • Author(s)
      萩原正敏、野島孝之
    • Journal Title

      実験医学

      Volume: 27(10) Pages: 42-47

    • Related Report
      2009 Annual Research Report
  • [Journal Article] mRNAスプライシング制御から難治疾患の治療へ2009

    • Author(s)
      萩原正敏
    • Journal Title

      実験医学

      Volume: 27(17) Pages: 190-195

    • Related Report
      2009 Annual Research Report
  • [Journal Article] リン酸化依存的スプライシング制御機構2009

    • Author(s)
      萩原正敏
    • Journal Title

      蛋白質 核酸 酵素

      Volume: 54(16) Pages: 2055-2059

    • Related Report
      2009 Annual Research Report
  • [Presentation] Academia drug discovery with novel strategies of chemical biology.2018

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      International Chemical Biology Society.
    • Place of Presentation
      China-Shanghai
    • Year and Date
      2018-10-17
    • Related Report
      Products Report
  • [Presentation] 小分子化合物の新しい可能性 : 遺伝病治療や再生医療の実現に向けて2018

    • Author(s)
      萩原正敏
    • Organizer
      日本農芸化学会2018年度大会 学術活動強化委員会企画シンポジウム~ケミカルバイオロジー研究の最前線~
    • Place of Presentation
      名古屋
    • Year and Date
      2018-03-16
    • Related Report
      Products Report
  • [Presentation] Forward Drug Discovery : 表現型スクリーニングから創薬標的の同定へ2018

    • Author(s)
      萩原正敏
    • Organizer
      京都府京大オフィス産学連携セミナー~創薬・医療技術の現場から~
    • Place of Presentation
      京都
    • Year and Date
      2018-03-14
    • Related Report
      Products Report
  • [Presentation] エピゲノム創薬で治療可能な難病について」2018

    • Author(s)
      萩原正敏
    • Organizer
      AMRF-CREST【エピゲノム】領域会議
    • Place of Presentation
      宮城
    • Year and Date
      2018-02-09
    • Related Report
      Products Report
  • [Presentation] RNAを標的としたアカデミア創薬2018

    • Author(s)
      萩原正敏
    • Organizer
      第9回新たな創薬パラダイムの創出
    • Place of Presentation
      東京
    • Year and Date
      2018-01-12
    • Related Report
      Products Report
  • [Presentation] スプライシング操作薬による遺伝病治療2017

    • Author(s)
      萩原正敏
    • Organizer
      2017年度生命科学系学会合同年次大会Con Bio2017
    • Place of Presentation
      兵庫
    • Year and Date
      2017-12-09
    • Related Report
      Products Report
  • [Presentation] Entrepreneurship Award Lecture2017

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      FAOBMB2017
    • Place of Presentation
      KOBE
    • Year and Date
      2017-12-07
    • Related Report
      Products Report
  • [Presentation] Chemical therapeutics of congenital diseases by manipulating transcriptome.2017

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Cutting Edge Developments in RNA Biology for the Control of Gene Expression.
    • Place of Presentation
      Okinawa-Japan
    • Year and Date
      2017-11-13
    • Related Report
      Products Report
  • [Presentation] アカデミア創薬のワンストップ拠点構想2017

    • Author(s)
      萩原正敏
    • Organizer
      京都大学医薬系総合研究棟「イノベーションハブ京都」開所式典
    • Place of Presentation
      京都
    • Year and Date
      2017-09-13
    • Related Report
      Products Report
  • [Presentation] 先天性神経疾患を標的とした創薬2017

    • Author(s)
      萩原正敏
    • Organizer
      第47回(2017)新潟神経学夏期セミナー
    • Place of Presentation
      新潟
    • Year and Date
      2017-07-29
    • Related Report
      Products Report
  • [Presentation] エピゲノム創薬で治療できる可能性のある神経疾患などの難病について2017

    • Author(s)
      萩原正敏
    • Organizer
      第44回日本毒性学会学術年会
    • Place of Presentation
      横浜
    • Year and Date
      2017-07-11
    • Related Report
      Products Report
  • [Presentation] 遺伝病を治す薬を創ろう!-学生時代からの夢の実現に向けて2017

    • Author(s)
      萩原正敏
    • Organizer
      平成29年度三医会定期総会
    • Place of Presentation
      三重
    • Year and Date
      2017-06-18
    • Related Report
      Products Report
  • [Presentation] 基礎研究から医師主導治験に至るワンストップ創薬2017

    • Author(s)
      萩原正敏
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-15
    • Related Report
      Products Report
  • [Presentation] 京都大学におけるアカデミア創薬の取り組みの紹介2017

    • Author(s)
      萩原正敏
    • Organizer
      The 1^<st> KYOTO-SPARK Symposium Construction of a Drug Discovery Ecosystem between Academia-Pharma
    • Place of Presentation
      京都
    • Year and Date
      2017-02-15
    • Related Report
      Products Report
  • [Presentation] 脳・生体イメージングの創薬への展開2017

    • Author(s)
      萩原正敏
    • Organizer
      シンポジウム「健康社会にむけた多次元脳・生体イメージングの総合的推進」
    • Place of Presentation
      東京
    • Year and Date
      2017-01-22
    • Related Report
      Products Report
  • [Presentation] 京都大学におけるアカデミア創薬の試み2017

    • Author(s)
      萩原正敏
    • Organizer
      公益社団法人 先端医療振興財団での講演会
    • Place of Presentation
      神戸
    • Year and Date
      2017-01-10
    • Related Report
      Products Report
  • [Presentation] RNAスプライシングを操作すれば遺伝情報の異常を是正できるか?2016

    • Author(s)
      萩原正敏
    • Organizer
      生理化学ユニットシンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2016-12-22
    • Related Report
      Products Report
  • [Presentation] 低分子化合物による再生医療の現実2016

    • Author(s)
      萩原正敏
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-12-01
    • Related Report
      Products Report
  • [Presentation] New chemical therapeutics of genetic diseases by manipulating transcriptome2016

    • Author(s)
      萩原正敏
    • Organizer
      Tokyo Medical & Dental University 15^<th> Surugadai International Symposium & Joint Usage/Research Program of medical research Institute International Symposium
    • Place of Presentation
      東京
    • Year and Date
      2016-11-29
    • Related Report
      Products Report
  • [Presentation] エクソンスキップ誘導薬とエクソン含有誘導薬による遺伝性難病の治療2016

    • Author(s)
      萩原正敏
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      宮城
    • Year and Date
      2016-09-25
    • Related Report
      Products Report
  • [Presentation] トランスクリプトーム創薬の実現に向けて2016

    • Author(s)
      萩原正敏
    • Organizer
      第43回日本毒性学会学術年会
    • Place of Presentation
      愛知
    • Year and Date
      2016-07-01
    • Related Report
      Products Report
  • [Presentation] Drug Discovery in Academia -from the drug screening to the clinical trial-2016

    • Author(s)
      萩原正敏
    • Organizer
      日本ケミカルバイオロジー学会第11回年会(日豪合同ケミカルバイオロジーシンポジウム)
    • Place of Presentation
      京都
    • Year and Date
      2016-06-16
    • Related Report
      Products Report
  • [Presentation] 京都大学発アカデミア創薬-卓越した基礎研究から医師主導治験まで-2016

    • Author(s)
      萩原正敏
    • Organizer
      第8回関西ライフサイエンス・リーディングサイエンティストセミナー
    • Place of Presentation
      大阪
    • Year and Date
      2016-06-10
    • Related Report
      Products Report
  • [Presentation] Diseasome情報を活用したPhenomics創薬へ2016

    • Author(s)
      萩原正敏
    • Organizer
      第105回病理学会総会
    • Place of Presentation
      宮城
    • Year and Date
      2016-05-13
    • Related Report
      Products Report
  • [Presentation] 先天性難治疾患のスプライシング治療2015

    • Author(s)
      萩原正敏
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      Products Report
  • [Presentation] 京都大学におけるワンストップ創薬の試み-卓越した基礎研究から迅速な臨床試験まで-2015

    • Author(s)
      萩原正敏
    • Organizer
      エーザイ株式会社社内研究者向け講演会
    • Place of Presentation
      茨城
    • Year and Date
      2015-10-27
    • Related Report
      Products Report
  • [Presentation] New chemical therapeutics of genetic diseases by manipulating transcriptome.2015

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Top Global University Japan, 1^<st> Joint Symposium of International Partners.
    • Place of Presentation
      Kyoto JAPAN.
    • Year and Date
      2015-10-02
    • Related Report
      Products Report
  • [Presentation] 卓越した基礎研究から迅速な臨床試験まで : 京都大学におけるワンストップ創薬の試み2015

    • Author(s)
      萩原正敏
    • Organizer
      藤田保健衛生大学研究最前線セミナー
    • Place of Presentation
      愛知
    • Year and Date
      2015-10-01
    • Related Report
      Products Report
  • [Presentation] 今日は治せぬ病を、明日に治す医師を育てる2015

    • Author(s)
      萩原正敏
    • Organizer
      京都大学医学部校友会第8回総会・講演会
    • Place of Presentation
      京都
    • Year and Date
      2015-09-26
    • Related Report
      Products Report
  • [Presentation] アカデミアにおけるトランスクリプトーム創薬の試み2015

    • Author(s)
      萩原正敏
    • Organizer
      科研製薬株式会社における講演会
    • Place of Presentation
      京都
    • Year and Date
      2015-07-29
    • Related Report
      Products Report
  • [Presentation] 不治の難病に挑むトランスクリプトーム創薬2015

    • Author(s)
      萩原正敏
    • Organizer
      第42回日本毒性学会学術年会
    • Place of Presentation
      石川
    • Year and Date
      2015-07-01
    • Related Report
      Products Report
  • [Presentation] 幸運の女神に後髪なし~難病に対する治療薬開発について~2015

    • Author(s)
      萩原正敏
    • Organizer
      学校法人暁中学・高等学校 「第3回キャリア教育講演会」
    • Place of Presentation
      三重
    • Year and Date
      2015-06-17
    • Related Report
      Products Report
  • [Presentation] セレンディピティーを最大化するアカデミア創薬の試み2015

    • Author(s)
      萩原正敏
    • Organizer
      京都大学臨床研究総合センター研究セミナー
    • Place of Presentation
      京都
    • Year and Date
      2015-06-17
    • Related Report
      Products Report
  • [Presentation] トランスクリプトーム創薬による難病治療の試み2015

    • Author(s)
      萩原正敏
    • Organizer
      文部科学省科学研究費補助金「新学術領域研究(研究領域提案型)」第8回公開シンポジウム
    • Place of Presentation
      宮城
    • Year and Date
      2015-06-08
    • Related Report
      Products Report
  • [Presentation] トランスクリプトーム創薬による難病の革新的治療薬開発2015

    • Author(s)
      萩原正敏
    • Organizer
      第29回日本医学会総会2015
    • Place of Presentation
      京都
    • Year and Date
      2015-04-11
    • Related Report
      Products Report
  • [Presentation] Challenges to cure congenital diseases with RNA-targeting chemical compounds2015

    • Author(s)
      萩原正敏
    • Organizer
      Molecular Clock 2015 Epigenetic Landscape in Biological Rhythms
    • Place of Presentation
      京都
    • Year and Date
      2015-03-27
    • Related Report
      Products Report
  • [Presentation] 大学発-セレディピティーの最大化に向けて2015

    • Author(s)
      萩原正敏
    • Organizer
      薬学会第135年会シンポジウム「動き出した創薬オープンイノベーションネットワーク」
    • Place of Presentation
      兵庫
    • Year and Date
      2015-03-26
    • Related Report
      Products Report
  • [Presentation] 卓越した基礎研究から迅速な臨床試験まで : 京都大学におけるワンストップ創薬の試み2015

    • Author(s)
      萩原正敏
    • Organizer
      第88回日本薬理学会 シンポジウム19「ケミカルバイオロジーによる難病治療薬開発の最前線」
    • Place of Presentation
      愛知
    • Year and Date
      2015-03-19
    • Related Report
      Products Report
  • [Presentation] 情熱大陸2015

    • Author(s)
      萩原正敏
    • Organizer
      三重県立桑名高等学校パネルディスカッション
    • Place of Presentation
      三重
    • Year and Date
      2015-03-18
    • Related Report
      Products Report
  • [Presentation] 卓越した基礎研究から迅速な臨床試験まで : 京都大学におけるワンストップ創薬の試み2015

    • Author(s)
      萩原正敏
    • Organizer
      京大医学部・萩原先生の講演会(第一三共株式会社)
    • Place of Presentation
      東京
    • Year and Date
      2015-02-19
    • Related Report
      Products Report
  • [Presentation] 化合物スクリーニングから臨床試験まで : ワンストップ創薬拠点2015

    • Author(s)
      萩原正敏
    • Organizer
      PDIS最先端セミナー 創薬につなぐ日本の創薬基盤技術 構造生物学とゲノム科学の最前線はここまで来た
    • Place of Presentation
      東京
    • Year and Date
      2015-02-04
    • Related Report
      Products Report
  • [Presentation] 遺伝病に挑むトランスクリプトーム創薬2015

    • Author(s)
      萩原正敏
    • Organizer
      第三回Academy of Aging and Cardiovascular-Diabetes Research
    • Place of Presentation
      東京
    • Year and Date
      2015-01-10
    • Related Report
      Products Report
  • [Presentation] 難治性疾患に対する創薬2014

    • Author(s)
      萩原正敏
    • Organizer
      杏林製薬株式会社創薬研究所における講演会
    • Place of Presentation
      栃木
    • Year and Date
      2014-12-24
    • Related Report
      Products Report
  • [Presentation] RNA制御の全容解明への挑戦2014

    • Author(s)
      武内章英
    • Organizer
      第1回バイオ・フロンティア・プラットフォームシンポジウム「京滋地域アカデミア連関における研究支援体制の整備」
    • Place of Presentation
      京都
    • Year and Date
      2014-12-01
    • Related Report
      Products Report
  • [Presentation] 医学研究支援の取り組み : 持続的な研究環境・資源の維持に向けて2014

    • Author(s)
      萩原正敏
    • Organizer
      第1回バイオ・フロンティア・プラットフォームシンポジウム「京滋地域アカデミア連関における研究支援体制の整備」
    • Place of Presentation
      京都
    • Year and Date
      2014-12-01
    • Related Report
      Products Report
  • [Presentation] ゲノム創薬からセレンティビティ創薬への回帰2014

    • Author(s)
      萩原正敏
    • Organizer
      第2回遊人会関西支部会
    • Place of Presentation
      京都
    • Year and Date
      2014-11-28
    • Related Report
      Products Report
  • [Presentation] Challenges to cure genetic diseases with RNA-targeting chemical compounds.2014

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Seminar at Emory University school of Medicine Department of Pharmacology
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2014-11-21
    • Related Report
      Products Report
  • [Presentation] 先天性難治疾患の治療を可能にするトランスクリプトーム創薬戦略 Challenge to hereditary diseases with transcriptom the rapy2014

    • Author(s)
      萩原正敏
    • Organizer
      RCGMフロンティア国際シンポジウム
    • Place of Presentation
      埼玉
    • Year and Date
      2014-11-01
    • Related Report
      Products Report
  • [Presentation] Drug Discovery and Development in Academia-How to Maximize the Serentivity2014

    • Author(s)
      萩原正敏
    • Organizer
      NIHS SPECIAL LECTURE
    • Place of Presentation
      東京
    • Year and Date
      2014-10-29
    • Related Report
      Products Report
  • [Presentation] Drug Discovery and Development in Academia-How to Maximize the Serentivity?-2014

    • Author(s)
      萩原正敏
    • Organizer
      Cutting edge information exchange meeting
    • Place of Presentation
      京都
    • Year and Date
      2014-10-09
    • Related Report
      Products Report
  • [Presentation] Prospective novel therapeutics for tauopathies2014

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Asia Aging Core for Longevity(AACL)
    • Place of Presentation
      Jeju
    • Year and Date
      2014-09-24
    • Related Report
      Products Report
  • [Presentation] RNAを標的とする創薬によって難治疾患へ挑む2014

    • Author(s)
      萩原正敏
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      神奈川
    • Year and Date
      2014-09-11
    • Related Report
      Products Report
  • [Presentation] Challenges to cure genetic diseases with RNA-targeting chemical compounds2014

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      京都大学・台湾大学共催シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2014-09-02
    • Related Report
      Products Report
  • [Presentation] 先天性疾患の治療に挑むトランスクリプトーム創薬2014

    • Author(s)
      萩原正敏
    • Organizer
      日本プロテオーム学会2014年会
    • Place of Presentation
      茨城
    • Year and Date
      2014-07-18
    • Related Report
      Products Report
  • [Presentation] 遺伝病治療を可能にするトランスクリプトーム創薬2014

    • Author(s)
      萩原正敏
    • Organizer
      第41回日本毒性学会学術年会
    • Place of Presentation
      兵庫
    • Year and Date
      2014-07-02
    • Related Report
      Products Report
  • [Presentation] トランスクリプトーム創薬による遺伝病の克服2014

    • Author(s)
      萩原正敏
    • Organizer
      第4回前立腺生物学シンポジウム 伊勢志摩2014
    • Place of Presentation
      三重
    • Year and Date
      2014-06-27
    • Related Report
      Products Report
  • [Presentation] 今日は治せぬ病を、明日は治せる医師を、京大は育てる2014

    • Author(s)
      萩原正敏
    • Organizer
      立伊勢高等学校「第3回科学の甲子園全国優勝/サイエンス・オリンピアド参加報告会」
    • Place of Presentation
      三重
    • Year and Date
      2014-06-22
    • Related Report
      Products Report
  • [Presentation] Challenges to cure hereditary diseases with “RNA targeting” chemical compounds.2014

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Bordeaux-Kyoto Symposium, Université de Bordeaux
    • Place of Presentation
      Bordeaux, France
    • Year and Date
      2014-05-05
    • Related Report
      Products Report
  • [Presentation] Challenges to cure genetic disorders with RNA-targeting chemical compounds.2014

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Seminar at ICREA and Center for Genomic Regulation (CRG)
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-05-02
    • Related Report
      Products Report
  • [Presentation] Challenges to congenital genetic disorders with “RNA-targeting” chemical compounds.2014

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Seminar at washington University School of Medicine
    • Place of Presentation
      St. Louis USA
    • Year and Date
      2014-04-29
    • Related Report
      Products Report
  • [Presentation] Challenges to cure genetic diseases with RNA-targeting chemical compounds.2014

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Seminar at Sanford-Burnham Medical Research Institute
    • Place of Presentation
      San Diego USA
    • Year and Date
      2014-04-27
    • Related Report
      Products Report
  • [Presentation] 遺伝病治療を目指すトランスクリプトーム創薬2014

    • Author(s)
      萩原正敏
    • Organizer
      第16回「JBICバイオ関連基盤技術研究会」
    • Place of Presentation
      東京
    • Year and Date
      2014-04-15
    • Related Report
      Products Report
  • [Presentation] 家族性自立神経失調症を標的とするトランスクリプトーム創薬2014

    • Author(s)
      萩原正敏
    • Organizer
      千里ライフサイエンス新適塾『脳はおもしろい』第4回会合
    • Place of Presentation
      大阪
    • Year and Date
      2014-04-11
    • Related Report
      Products Report
  • [Presentation] RNAを標的とする創薬によって、今は治らぬ病を明日には治す!2014

    • Author(s)
      萩原正敏
    • Organizer
      第47回京都ききょう会生涯研修会
    • Place of Presentation
      京都
    • Year and Date
      2014-03-21
    • Related Report
      Products Report
  • [Presentation] Challenge to Cure Hereditary Diseases with “RNA-targeting” Chemical Compounds2014

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      International Conference on Chemical Biology 2014
    • Place of Presentation
      インド
    • Year and Date
      2014-02-07
    • Related Report
      Products Report
  • [Presentation] 京大医学研究科におけるティッシュリソースセンター構想2014

    • Author(s)
      萩原正敏
    • Organizer
      京大病院キャンサーバイオバンクシンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2014-02-03
    • Related Report
      Products Report
  • [Presentation] 網羅的スプライシング暗号解析に基づくRNA病の解明と治療技術の探索2014

    • Author(s)
      萩原正敏
    • Organizer
      平成25年度セルイノベーション公開シンポジウム 次世代シーケンス解析技術の超微量化と創薬・医療分野への応用に向けて
    • Place of Presentation
      東京
    • Year and Date
      2014-01-28
    • Related Report
      Products Report
  • [Presentation] RNA結合タンパクと難治の神経・筋疾患2014

    • Author(s)
      萩原正敏
    • Organizer
      転写終結タンパク質のセミナー
    • Place of Presentation
      東京
    • Year and Date
      2014-01-27
    • Related Report
      Products Report
  • [Presentation] 難治疾患の治療を可能にするトランスクリプトーム創薬戦略2014

    • Author(s)
      萩原正敏
    • Organizer
      The Graduate Course “Lifestyle-related diseases, Aging and Metabolism” Course Retreat 2013
    • Place of Presentation
      京都
    • Year and Date
      2014-01-19
    • Related Report
      Products Report
  • [Presentation] 先天性難治疾患の治療を可能にするトランスクリプトーム創薬戦略2013

    • Author(s)
      萩原正敏
    • Organizer
      第2回創薬・医療技術基盤プログラムワークショップ「理研発創薬の現状と将来」
    • Place of Presentation
      埼玉
    • Year and Date
      2013-11-29
    • Related Report
      Products Report
  • [Presentation] Development of DYRK1A inhibitors for novel therapeutics of Alzheimer's disease.2013

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      6^<th> Asian Aging Core for Longevity (AACL) conference in Kyoto (Aging Research Forum between Japan and Korea)
    • Place of Presentation
      京都
    • Year and Date
      2013-11-02
    • Related Report
      Products Report
  • [Presentation] 広汎性発達障害に対するエピゲノム創薬2013

    • Author(s)
      萩原正敏
    • Organizer
      第23回日本臨床精神神経薬理学会・第43回日本神経精神薬理学会合同年会シンポジウム「エピジェネティクスと精神薬理との接点」
    • Place of Presentation
      沖縄
    • Year and Date
      2013-10-25
    • Related Report
      Products Report
  • [Presentation] 明日の医療を育む2013

    • Author(s)
      萩原正敏
    • Organizer
      白菊会総会
    • Place of Presentation
      京都
    • Year and Date
      2013-10-18
    • Related Report
      Products Report
  • [Presentation] RNAプロセシング異常と神経疾患2013

    • Author(s)
      萩原正敏
    • Organizer
      京都府立医科大学医学研究科講義
    • Place of Presentation
      京都
    • Year and Date
      2013-10-01
    • Related Report
      Products Report
  • [Presentation] 先天性難治疾患に対する創薬の試み : TRNDK2013

    • Author(s)
      萩原正敏
    • Organizer
      第1回創薬等支援技術基盤プラットフォーム公開シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2013-09-24
    • Related Report
      Products Report
  • [Presentation] 核内タンパク・RNA複合体の構造と機能2013

    • Author(s)
      萩原正敏
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2013-09-11
    • Related Report
      Products Report
  • [Presentation] 難治疾患の治療を可能にするトランスクリプトーム創薬戦略2013

    • Author(s)
      萩原正敏
    • Organizer
      第6回リサーチ・イノベーションミーティング
    • Place of Presentation
      神戸
    • Year and Date
      2013-08-31
    • Related Report
      Products Report
  • [Presentation] 京都大学医学部の歴史と医学教育2013

    • Author(s)
      萩原正敏
    • Organizer
      第14回近畿献体懇話会
    • Place of Presentation
      京都
    • Year and Date
      2013-07-24
    • Related Report
      Products Report
  • [Presentation] RNAを標的とする創薬によって難治疾患へ挑む2013

    • Author(s)
      萩原正敏
    • Organizer
      大阪大学セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2013-07-04
    • Related Report
      Products Report
  • [Presentation] トランスクリプトーム創薬による遺伝病への挑戦2013

    • Author(s)
      萩原正敏
    • Organizer
      奈良県立医科大学第二回基礎教育協議会講演会
    • Place of Presentation
      奈良
    • Year and Date
      2013-06-28
    • Related Report
      Products Report
  • [Presentation] Visualization and manipulation of pre-mRNA processing2013

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      「時空間情報イメージング研究教育推進拠点」キックオフシンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2013-05-23
    • Related Report
      Products Report
  • [Presentation] 京都大学におけるセレンディピティ創薬の試み2013

    • Author(s)
      萩原正敏
    • Organizer
      公開シンポジウム「オールジャパンでの創薬支援体制の構築に向けて」
    • Place of Presentation
      大阪
    • Year and Date
      2013-05-17
    • Related Report
      Products Report
  • [Presentation] RNAを標的とする創薬によって難治疾患へ挑む ; ダウン症からアルツハイマー病治療薬へ2013

    • Author(s)
      萩原正敏
    • Organizer
      いなべ市医師会学術講演会
    • Place of Presentation
      三重(いなべ)
    • Year and Date
      2013-03-30
    • Related Report
      Products Report
  • [Presentation] 医薬連携によるワンストップ創薬2013

    • Author(s)
      萩原正敏
    • Organizer
      日本薬理学会アカデミア創薬シーズ探索シンポジウム
    • Place of Presentation
      博多
    • Year and Date
      2013-03-22
    • Related Report
      Products Report
  • [Presentation] mRNAを標的とした新しい創薬研究の展開2013

    • Author(s)
      萩原正敏
    • Organizer
      長野哲雄教授定年退職記念シンポジウム「ケミカルバイオロジーの大展開」
    • Place of Presentation
      東京
    • Year and Date
      2013-03-16
    • Related Report
      Products Report
  • [Presentation] RNAを標的とする創薬で難病に挑む2013

    • Author(s)
      萩原正敏
    • Organizer
      未来の研究プロジェクトWinter Seminar 2013
    • Place of Presentation
      京都
    • Year and Date
      2013-02-16
    • Related Report
      Products Report
  • [Presentation] RNAを標的とする創薬によって難治疾患へ挑む2013

    • Author(s)
      萩原正敏
    • Organizer
      臨床中核拠点シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2013-02-09
    • Related Report
      Products Report
  • [Presentation] RNAを標的とする創薬で難病に挑む2013

    • Author(s)
      萩原正敏
    • Organizer
      三重大学医学研究科特別講義
    • Place of Presentation
      三重
    • Year and Date
      2013-02-01
    • Related Report
      Products Report
  • [Presentation] プロテオームの多様性創出のメカニズムについて2013

    • Author(s)
      萩原正敏
    • Organizer
      JHUPO サテライトシンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2013-01-18
    • Related Report
      2011 Final Research Report Products Report
  • [Presentation] スプライシング異常による疾患とその治療の可能性2012

    • Author(s)
      萩原正敏
    • Organizer
      オミックス医療研究会 創薬PG×分科会&データベース分科会シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2012-12-26
    • Related Report
      Products Report
  • [Presentation] スペックルズ・パラスペックルズに局在するRNA結合蛋白の機能2012

    • Author(s)
      萩原正敏
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-11
    • Related Report
      Products Report
  • [Presentation] Novel DYRK1A inhibitor applicable for Alzheimer disease2012

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      AACL-2012 Seoul Symposium
    • Place of Presentation
      Seoul
    • Year and Date
      2012-11-23
    • Related Report
      Products Report
  • [Presentation] RNAを標的とする創薬で難病に挑む2012

    • Author(s)
      萩原正敏
    • Organizer
      京大医療薬剤学研究会
    • Place of Presentation
      京都
    • Year and Date
      2012-11-17
    • Related Report
      Products Report
  • [Presentation] 今日は治せぬ病を、明日は治せる医師を、京大が育てる2012

    • Author(s)
      萩原正敏
    • Organizer
      京都大学医学部ホームカミングディ
    • Place of Presentation
      京都
    • Year and Date
      2012-11-10
    • Related Report
      Products Report
  • [Presentation] RNAを操作して先天性の神経筋疾患を薬で治す2012

    • Author(s)
      萩原正敏
    • Organizer
      長崎大学医学研究科セミナー
    • Place of Presentation
      長崎
    • Year and Date
      2012-10-16
    • Related Report
      Products Report
  • [Presentation] Chemical targeting of RNA processing for new therapeutics of congenital diseases2012

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      THE 1^<st> official of the INTERNATIONAL CHEMICALBIOLOGY SOCIETY
    • Place of Presentation
      Cambridge, USA.
    • Year and Date
      2012-10-04
    • Related Report
      Products Report
  • [Presentation] New chemical screens for drugs of congenital genetic disorders targeting pre-mRNAs.2012

    • Author(s)
      萩原正敏
    • Organizer
      名古屋大学農学研究科大学院セミナー
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-24
    • Related Report
      Products Report
  • [Presentation] Neural development and splicing code2012

    • Author(s)
      萩原正敏
    • Organizer
      第35回日本神経科学大会「RNA 結合タンパクと病態シンポジウム」
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-21
    • Related Report
      2011 Final Research Report Products Report
  • [Presentation] RNA を標的とする創薬によって難治疾患に挑む2012

    • Author(s)
      萩原正敏
    • Organizer
      第36回阿蘇シンポジウム
    • Place of Presentation
      熊本
    • Year and Date
      2012-08-03
    • Related Report
      2011 Final Research Report Products Report
  • [Presentation] New chemical screens for drugs of congenital genetic disorders targeting pre-mRNAs2012

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Newport, USA.
    • Year and Date
      2012-07-19
    • Related Report
      2011 Final Research Report
  • [Presentation] RNA制御異常2012

    • Author(s)
      萩原正敏
    • Organizer
      京都大学大学院医学研究科教育コース、神経科学ミニコース「脳科学研究に資する分子ネットワーク解析の最前線」
    • Place of Presentation
      京都
    • Year and Date
      2012-07-13
    • Related Report
      Products Report
  • [Presentation] Challenges to Congenital Genetic Disorders with "RNA-targeting" Chemical Compounds2012

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      The 22^<nd> CDB Meeting
    • Place of Presentation
      Kobe
    • Year and Date
      2012-06-11
    • Related Report
      2011 Final Research Report Products Report
  • [Presentation] New chemical therapeutics of congenital genetic disorders targeting pre-mRNA2012

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      日本ケミカルバイオロジー学会第7回年会、国際シンポジウム「新規疾患治療にむけたケミカルバイオロジー研究からの挑戦」
    • Place of Presentation
      京都
    • Year and Date
      2012-06-09
    • Related Report
      Products Report
  • [Presentation] 哺乳類の脳の発生過程でのmRNA制御の網羅的解析2012

    • Author(s)
      武内章英
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨山梨大学甲府キャンパス
    • Year and Date
      2012-03-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Challenges to congenital genetic disorder with"RNA-targeting" chemical compounds2012

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      SLAS2013 2^<nd> Annual Conference &Exhibition
    • Place of Presentation
      ORLAND,FL,USA.
    • Year and Date
      2012-01-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Chemical targeting of RNA processing for new therapeutics of congenital diseases2012

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      THE 1st official of the INTERNATIONAL CHEMICALBIOLOGY SOCIETY
    • Place of Presentation
      Cambridge,USA.
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Modulation of mRNA Splicing with Synthetic Kinase Inhibitors and Their Clinical Applications2011

    • Author(s)
      萩原正敏
    • Organizer
      Protein Kinass Regulating RNA Splicing, 2011
    • Place of Presentation
      ROSCOFF、フランス(招待講演)
    • Year and Date
      2011-11-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] New therapeutics by alteration of mRNA expression and processing with small chemicals2011

    • Author(s)
      萩原正敏
    • Organizer
      International Chemical Biology Conference
    • Place of Presentation
      Kauffman Foundation Conference, USA
    • Year and Date
      2011-10-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] RNAを操作して先天性疾患を薬で治す2011

    • Author(s)
      萩原正敏
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都、京都国際会議場
    • Year and Date
      2011-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Modulation of pre-mRNA splicing patterns with synthetic chemicals and their clinical applications2011

    • Author(s)
      萩原正敏
    • Organizer
      JST-CRDS主催俯瞰ワークショップ「構造生命科学動的構造情報から創薬へ
    • Place of Presentation
      東京、JST研究開発戦略センター2階大会議室(招待講演)
    • Year and Date
      2011-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Chembiomolecular Medicinal Chemistry2011

    • Author(s)
      萩原正敏
    • Organizer
      第10回上原記念生命科学財団国際シンポジウ「生体制御分子科学」
    • Place of Presentation
      東京、ハイアットリージェンシー東京(招待講演)
    • Year and Date
      2011-06-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Chemical Treatment enhances skipping of amutated exon in the dystrophin gene2011

    • Author(s)
      片岡直行、西田篤史、竹島泰弘、八木真理子、粟野宏之、大田光徳、伊東恭子、松尾雅文、萩原正敏
    • Organizer
      日本ケミカルバイオロジー学会 第6回年会
    • Place of Presentation
      東京、東京工業大学
    • Year and Date
      2011-05-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 核内構造体(核スペックル)の形成と選択的スプライシングの低分子化合物による制御2011

    • Author(s)
      松尾陽太、三原由揮、椛本大和、八木浩亮、上原裕也、岩本はる香、萩原正敏, 他
    • Organizer
      日本ケミカルバイオロジー学会第6回年会
    • Place of Presentation
      東京、東京工業大学
    • Year and Date
      2011-05-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] ダウン症など先天性難治疾患への挑戦RNAを標的とした創薬の試み2011

    • Author(s)
      萩原正敏
    • Organizer
      第24回近畿小児科学会
    • Place of Presentation
      神戸、国際会議場(招待講演)
    • Year and Date
      2011-03-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Modulation of pre-mRNA splicing patterns with synthetic chemicals and their clinical applications2011

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      第10回上原記念生命科学財団 国際シンポジウム[生体制御分子科学]
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] Visuali zation of alternative splicing and the therapeutic manipulation with chemical compounds2011

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      US - Japan Sumer Conference
    • Place of Presentation
      USA
    • Related Report
      2011 Final Research Report
  • [Presentation] New therapeutics by alteration of mRNA expression and processing with small chemicals"2011

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      International Chemical Biology Conference
    • Place of Presentation
      USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Visualization of Alternative Splithin with Multi-color Splicing Reporters and Their Application for Screen of Trans-acting Factors and Small Chemicals2011

    • Author(s)
      萩原正敏
    • Organizer
      The16th Annual Meeting of the RNA Society/The RNA Society of Japan 13^<th> Annual Meeting
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Splicing resume from stress response2010

    • Author(s)
      萩原正敏
    • Organizer
      Asian Cold Spring Harbor Laboratory 'RNA Biology
    • Place of Presentation
      Suzhou、中国(招待講演)
    • Year and Date
      2010-11-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Visualization and manipulation of alternative pre-mRNA splicing2010

    • Author(s)
      萩原正敏
    • Organizer
      中国医科大学大学院特別セミナー
    • Place of Presentation
      中国医科大学(瀋陽)
    • Year and Date
      2010-10-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Pre-mRNAスプライシングの組織特異的制御とその異常に起因する疾患2010

    • Author(s)
      萩原正敏
    • Organizer
      大学院セミナー
    • Place of Presentation
      京都大学医学部
    • Year and Date
      2010-09-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Pre-mRNAスプライシングの組織特異的制御とその異常に起因する疾患2010

    • Author(s)
      萩原正敏
    • Organizer
      北海道大学医学部眼科学講座セミナー
    • Place of Presentation
      北海道大学医学部
    • Year and Date
      2010-09-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Visualization and manipulation of mRNA splicing2010

    • Author(s)
      萩原正敏
    • Organizer
      国際生化学分子生物学会
    • Place of Presentation
      上海インターナショナルコンベンションセンター
    • Year and Date
      2010-08-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Visualizatio and manipulation of RNA splicing to cure RNA diseases2010

    • Author(s)
      萩原正敏
    • Organizer
      Gorodon Research Conference
    • Place of Presentation
      New port, RI, USA(招待講演)
    • Year and Date
      2010-07-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 蛋白リン酸化酵素を標的とした創薬:ケミカルバイオロジーによるアプローチ2010

    • Author(s)
      萩原正敏
    • Organizer
      平成21年度生命融合科学教育部シンポジウム
    • Place of Presentation
      富山県 高志会館カルチャーホール
    • Year and Date
      2010-03-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新しい分子イメージング技術による創薬2010

    • Author(s)
      萩原正敏
    • Organizer
      第5回ケミカルバイオロジー・第2回センシングバイオロジーシンポジウム
    • Place of Presentation
      東京医科歯科大学 臨床講堂
    • Year and Date
      2010-02-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] RNA病を斬る/RNAプロセッシング異常に対する創薬の試み2010

    • Author(s)
      萩原正敏
    • Organizer
      オミックス創薬科学セミナー
    • Place of Presentation
      三重大学大学院
    • Year and Date
      2010-01-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Visualizatio and manipulation of RNA splicing to cure RNA diseases2010

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Gorodon Research Conference
    • Place of Presentation
      New port, RI
    • Related Report
      2011 Final Research Report
  • [Presentation] Splicing resume from stress response2010

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Asian Cold Spring Harbor Laboratory 'RNA Biology'
    • Place of Presentation
      Suzhou Dushu Lake Conference Center , China
    • Related Report
      2011 Final Research Report
  • [Presentation] Decipherment of splicing code and its manipulation for new therapeutics.2010

    • Author(s)
      萩原正敏
    • Organizer
      2010 RNA国際シンポジウム
    • Place of Presentation
      National Cheng Kung University Medical College(台南)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Host viral interaction on RNA processing2009

    • Author(s)
      萩原正敏
    • Organizer
      TMDU-CMU国際シンポジウム
    • Place of Presentation
      東京医科歯科大学 歯学部講堂
    • Year and Date
      2009-10-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] ケミカルバイオロジーによる難治疾患への挑戦2009

    • Author(s)
      萩原正敏
    • Organizer
      日本薬理学会第81回関東部会
    • Place of Presentation
      東京医科歯科大学 5号館講堂
    • Year and Date
      2009-07-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] ストレス下でのpre-mRNAの選択的スプライシング2009

    • Author(s)
      萩原正敏
    • Organizer
      第82回日本生化学大会シンポジウム
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2009 Annual Research Report
  • [Presentation] Session 3「神経疾患におけるスプライシング異常とその制御」2009

    • Author(s)
      萩原正敏
    • Organizer
      第2回グローバルCOE国際シンポジウム
    • Place of Presentation
      ヒルトン名古屋
    • Related Report
      2009 Annual Research Report
  • [Presentation] New chemicaltherapeutics ofcongenital genetic disorders targeting pre-mRNA.

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      日本ケミカルバイオロジー学会第7回年会、国際シンポジウム「新規疾患治療にむけたケミカルバイオロジー研究からの挑戦」
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] Challenges to Congenital Genetic Disorders with "RNA-targeting" Chemical Compounds

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      The 22nd CDB Meeting
    • Place of Presentation
      神戸
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] New chemical screens for drugs of congenital genetic disorders targeting pre-mRNAs

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Newport, USA
    • Related Report
      2011 Annual Research Report Products Report
    • Invited
  • [Presentation] Challenges to congenital genetic disorder with “RNA-targeting” chemical compounds

    • Author(s)
      Masatoshi Hagiwara
    • Organizer
      SLAS2013 2nd Annual Conference & Exhibition
    • Place of Presentation
      ORLAND,FL,USA.
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 「 RNAを標的とする創薬によって難治疾患に挑む」

    • Author(s)
      萩原正敏
    • Organizer
      第36回阿蘇シンポジウム
    • Place of Presentation
      熊本
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 「Neural development and splicing code」

    • Author(s)
      萩原正敏
    • Organizer
      第35回日本神経科学大会「RNA結合タンパクと病態シンポジウム」
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 「スペックルズ・パラスペックルズに局在するRNA結合蛋白の機能」

    • Author(s)
      萩原正敏
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 「プロテオームの多様性創出のメカニズムについて」

    • Author(s)
      萩原正敏
    • Organizer
      HUPOサテライトシンポジウム
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Remarks]

    • URL

      http://www.med.kyoto-u.ac.jp/organization-staff/research/doctoral_course/r-002/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.anat1dadb.med.kyoto-u.ac.jp/Anat1DADB/HOME/HOME.html

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] Transgenic reporter system that reveals expression profiles and regulation mechanisms of alternative splicing in mammalian organisms2011

    • Inventor(s)
      萩原正敏、武内章英
    • Industrial Property Rights Holder
      萩原正敏、武内章英
    • Filing Date
      2011-05-31
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 遺伝性疾患の予防・改善剤2011

    • Inventor(s)
      萩原正敏、片岡直行、松尾雅文、西田篤史
    • Industrial Property Rights Holder
      萩原正敏、片岡直行、松尾雅文、西田篤史
    • Industrial Property Number
      2010-146699
    • Filing Date
      2011-06-27
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] Transgenic reporter system that reveals expression profile and regulation mechanisms of alternative splicing in mammalian organisms2011

    • Inventor(s)
      萩原正敏、武内章英
    • Industrial Property Rights Holder
      萩原正敏、武内章英
    • Filing Date
      2011-05-31
    • Description
      US.61/350,420 2010年6月1日(米国)
    • Related Report
      Products Report
    • Overseas
  • [Patent(Industrial Property Rights)] 遺伝性疾患の予防・改善剤2011

    • Inventor(s)
      片岡直行、松尾雅文、西田篤史
    • Industrial Property Rights Holder
      片岡直行、松尾雅文、西田篤史
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-522455
    • Filing Date
      2011-06-27
    • Description
      13/805,151(US) 11800411.8(EP) 201611191464.0(CN) 2011800303273.8(CN分割) 2012.12.18(US) 2012.12.21(EP) 2011.6.27(CN) 2016.12.21(CN分割)
    • Related Report
      Products Report
  • [Patent(Industrial Property Rights)] Transgenic reporter system that reveals expression profile and regulation mechanisms of alternative splicing in mammalian organisms2011

    • Inventor(s)
      萩原正敏、武内章英
    • Industrial Property Rights Holder
      萩原正敏、武内章英
    • Filing Date
      2011-05-31
    • Acquisition Date
      2016-01-29
    • Description
      9,273,364(US) 2576778(EP) 2012.11.29(US) 2013.1.1(EP) 2016.3.1(US) 2017.8.9(EP)
    • Related Report
      Products Report
  • [Patent(Industrial Property Rights)] 遺伝性疾患の予防・改善剤2011

    • Inventor(s)
      片岡直行、松尾雅文、西田篤史
    • Industrial Property Rights Holder
      片岡直行、松尾雅文、西田篤史
    • Filing Date
      2011-06-27
    • Acquisition Date
      2016-06-17
    • Description
      9,241,929(US) 2012.12.18(US) 2016.1.26(US)
    • Related Report
      Products Report
  • [Patent(Industrial Property Rights)] Transgenic reporter system that reveals expression profiles and regulation mechanisms of alternative splicing in mammalian organisms2010

    • Inventor(s)
      萩原正敏, 武内章英
    • Industrial Property Rights Holder
      萩原正敏, 武内章英
    • Filing Date
      2010
    • Related Report
      2010 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 遺伝性疾患の予防・改善剤2010

    • Inventor(s)
      片岡直行、松尾雅文、西田篤史
    • Industrial Property Rights Holder
      片岡直行、松尾雅文、西田篤史
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2010-146699
    • Filing Date
      2010-06-28
    • Description
      PCT/JP2011/003655 2011年6月27日(PCT)
    • Related Report
      Products Report

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Published: 2009-04-01   Modified: 2019-02-27  

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