Screening of sporozoite receptor molecule(s) on hepatocytes
| Project/Area Number |
21390124
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Ehime University |
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Principal Investigator |
TORII Motomi 愛媛大学, 大学院・医学系研究科, 教授 (20164072)
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| Co-Investigator(Kenkyū-buntansha) |
TOMOKO Ishino 愛媛大学, 大学院医学系研究科, 准教授 (40402680)
大槻 均 鳥取大学, 医学部, 講師 (80403806)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | マラリア原虫 / スポロゾイト / 細胞侵入 / 肝細胞侵入 / マイクロネーム / 原虫 / マラリア / 侵入 |
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| Research Abstract |
Characterization of P36p, the sporozoite secreted proteins involved in hepatocyte infection, was performed using monoclonal antibody. It was revealed that P36p starts expression after sporozoites released into hemolymph and stored in microneme, the apical organelle, until they are secreted before or during hepatocyte invasion. Moreover, 6 rhoptry molecules commonly expressed in target cell infective stages(merozoite and sporozoites) were identified.
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Report
(4 results)
Research Products
(12 results)
