| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2009: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Research Abstract |
Characterization of P36p, the sporozoite secreted proteins involved in hepatocyte infection, was performed using monoclonal antibody. It was revealed that P36p starts expression after sporozoites released into hemolymph and stored in microneme, the apical organelle, until they are secreted before or during hepatocyte invasion. Moreover, 6 rhoptry molecules commonly expressed in target cell infective stages(merozoite and sporozoites) were identified.
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