| Project/Area Number |
21390524
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Nagoya University |
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Principal Investigator |
UEDA Minoru 名古屋大学, 医学系研究科, 教授 (00151803)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Akihito 名古屋大学, 大学院・医学系研究科, 准教授 (50244083)
TANAKA Miturou 岩手医科大学, 歯学部, 教授 (10143596)
KUNISADA Takahiro 岐阜大学, 医学(系)研究科(研究院), 教授 (30205108)
山田 陽一 名古屋大学, 医学部附属病院, 助教 (20345903)
中村 さやか 名古屋大学, 医学部附属病院, 医員 (40437033)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | 歯髄幹細胞 / セルバンク / 再生医療 / 難治性疾患治療 / 細胞バンキング / 難治性疾患 / 脳梗塞 / 脊髄損傷 / 劇症肝炎 / 間葉系幹細胞 / 損傷治癒 / 培養上清 / パラクライン効果 / バンキング / 再生治療 / パーキンソン病 / 骨・軟骨再生 / 生体内幹細胞 / 難治性神経疾患 / 神経幹細胞 / 脊髄小脳変性症 / apoptosis / 神経軸索伸張 |
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| Research Abstract |
According to the development of the cell banking technology, weestablished a system that allows to quickly prepare dental pulp stem cell for transplantation into the diseased area. Furthermore, we found remarkable therapeutic benefits of serum free conditioned media (CM) of the dental pulp stem cells for treatment of the various intractable diseases, including cerebral infraction, severe bone defects, spinal cordinjury and fulminant hepatic failure. Our study demonstrate a marked advantage of newly developed cell banking system and therapeutic benefits of the dental pulp stem cells and their CMs for treatment of the multiple refractory diseases.
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