| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Research Abstract |
(1) HBV DNA in HCC tissues from children patients was detected in 36 of 42 (86%) cases tested. Surprisingly, very high prevalence of HBV pre-S deletion mutant was recognized in 27 of 30 (90%) HCCs examined. Interestingly, the pre-S2 mutant consistently appeared with deletion at nt 4-57 in all of the 20 cases with pre-S2 mutant (100%). This hot spot mutation in the pre-S2 was further confirmed by complete genomic sequence of HBV in a Japanese boy who eventually developed HCC.
(2) We identified a novel subgenotype HBV/D10 in Taiwanese aborigine HBV carriers.
(3) HBV infection appears to be associated with the pathogenesis of intrahepatic cholangiocarcinoma (ICC) in northern China. The high fatality rate of cholangiocarcinoma intensifies the need for further research to understand the precise mechanism of HBV infection and the development of ICC.
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