the novel non pharmaceutical therapy for patients with chronic renal failure using low temperature sauna

• Project/Area Number: 21500505
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kumamoto Health Science University
• Principal Investigator: IIYAMA Junichi 熊本保健科学大学, 保健科学部, 教授 (00398299)
• Co-Investigator(Renkei-kenkyūsha): KITAMURA Kenichirou 熊本大学, 医学部附属病院, 講師 (10304990)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 温熱療法 / 低温サウナ / 慢性腎不全 / 一酸化窒素 / 血管内皮機能 / 非薬物療法 / 腎不全 / リハビリテーション

Research Abstract

We have been investigating about the effects of low temperature sauna for renal failure using the mice of 5/6 renal extracted model. Although we firstly intended to use rats, we decided to use mice because of its usefulness as gene knocked out model. Our plan has been delayed due to taking many days to create the suitable renal failure model. We will try to make the evidences of low temperature sauna therapy for renal failure in the near future.

Research Products

• [Journal Article] 温熱の消化器・腎・皮膚への影響 (2011)
  • Author(s): 飯山準一
  • Journal Title: Japanese Journal of Rehabilitation Medicine Volume: vol.48(1) Pages: 28-32
  • Peer Reviewed
• [Journal Article] Proteolytic activation of ENaC and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension (2011)
  • Author(s): Kitamura, K., Tomita, K
  • Journal Title: Clin. Exp. Nephrol Volume: 16(1) Pages: 44-8
  • Peer Reviewed
• [Journal Article] A case of anti-glomerular basement membrane antibody-induced glomerulonephritis with cytomegalovirus-induced thrombotic microangiopathy (2011)
  • Author(s): Shiraishi, N., Kitamura, K., Tomita, K., et al
  • Journal Title: Intern. Med. J. Volume: 76(4) Pages: 266-72
  • Peer Reviewed
• [Journal Article] A study of maintenance therapy after intravenous maxacalcitol for secondary hyperparathyroidism (2011)
  • Author(s): Adachi, M., Tomita, K., Kitamura, K
  • Journal Title: Clin. Nephrol Volume: 76 Pages: 266-272
  • Peer Reviewed
• [Journal Article] Cys34 on antioxidative propertie of HSA quantitative analysis of cysteine-34 on the anitioxidative properties of human serum albumin in hemodialysis patients (2011)
  • Author(s): Anraku, M., Kitamura, K., Tomita, K., et al
  • Journal Title: J. Pharm. Sci Volume: 100 Pages: 3968-3976
  • Peer Reviewed
• [Journal Article] Regulation of renal sodium handling through the interaction between serine proteases and serine protease inhibitors (2010)
  • Author(s): Kitamura, K. and Tomita, K.
  • Journal Title: Clim. Exp. Nephrol Volume: 14 Pages: 405-10
  • NAID: 10027706988
  • Peer Reviewed
• [Journal Article] Regulation of adrenal aldosterone production by serine protease prostasin (2010)
  • Author(s): Ko, T., Tomita, K., Kitamura, K., et al
  • Journal Title: J. Biomed. Biotech Pages: 793843-793843
  • Peer Reviewed
• [Journal Article] Human sodium-phosphate transporter 4(hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate (2010)
  • Author(s): Jutabha, P., Kitamura, K., Tomita, K., et al
  • Journal Title: J. BIOL. Chem
  • Peer Reviewed
• [Journal Article] Aberrant ENaC activation in Dahl salt-sensitive rats (2009)
  • Author(s): Kakizoe, Y., Kitamura, K., Tomita, K., et al
  • Journal Title: J. Hypertens Volume: 27 Pages: 1679-1689
  • Peer Reviewed
• [Journal Article] Urinary prostasin in humans : relationships among prostasin, aldosterone and epithelial sodium channel activity (2009)
  • Author(s): Koda, A., Tomita, K., Kitamura, K., et al
  • Journal Title: Hypertens. Res Volume: 32 Pages: 267-281
  • NAID: 10024830568
  • Peer Reviewed
• [Journal Article] Camostat mesilate inhibits prostasin activity, and reduces blood pressure and renal injury in salt-sensitive hypertension (2009)
  • Author(s): Maekawa, A., Tomita, K., Kitamura, K., et al
  • Journal Title: J. Hypertens Volume: 27 Pages: 181-189
  • Peer Reviewed
• [Journal Article] Calreticulin positively regulates the expression and function of epithelial sodium channel (2009)
  • Author(s): Sugahara, T., Kitamura, K., Tomita, K., et a
  • Journal Title: Exp Cell Res Volume: 315 Pages: 3294-3300
  • Peer Reviewed
• [Journal Article] Improvements in limb kinetic apraxia by repetition of a newly designed facilitation exercise in a patient with corticobasal degeneration (2009)
  • Author(s): Kawahira K, Noma T, Iiyama J, Etoh S, Ogata A, Shimodozono M.
  • Journal Title: Int J Rehabil Res Volume: 32(2) Pages: 178-83
  • Peer Reviewed
• [Journal Article] グリセリン添加強酸性浴による皮膚性状変化について (2009)
  • Author(s): 飯山準一,川平和美
  • Journal Title: 日本温泉気候物理医学会雑誌 Volume: 73(1) Pages: 44-45
  • Peer Reviewed
• [Journal Article] 入浴による遺伝子転写、特異蛋白の誘導と免疫、臓器機能の変化入浴による肝・腎・腸管吸収機能の定量的分析 (2009)
  • Author(s): 飯山準一
  • Journal Title: 日本温泉気候物理医学会雑誌 Volume: 73(1) Pages: 30-30
  • Peer Reviewed
• [Journal Article] 入浴による遺伝子転写、特異蛋白の誘導と免疫、臟器機能の変化 入浴による肝・腎・腸管吸収機能の定量的分析 (2009)
  • Author(s): 飯山準一
  • Journal Title: 日本温泉気候物理医学会雑誌 73 Pages: 30-31
  • Peer Reviewed
• [Presentation] Effect of mist diameter of steam on the heating efficiency of whole body thermal therapy through respiratory tract (2011)
  • Author(s): Junichi Iiyama, Shinji Miyazaki, Shigehito Matsubara
  • Organizer: 6^<th> world congress of International Society of Physical and Rehabilitation Medicine
  • Place of Presentation: San Juan (Puerto Rico)
• [Presentation] 温泉はなぜ健康にいいの?～温泉基礎知識と健康のつながり～ (2010)
  • Author(s): 飯山準一
  • Organizer: 日奈久温泉マイスター講座
  • Place of Presentation: 八代市
  • Year and Date: 2010-11-15
• [Presentation] Effects of the heat inhalation as a novel method of whole body warming in normal subjects (2010)
  • Author(s): Junichi Iiyama
  • Organizer: 第8回地中海リハビリテーション医学会
  • Place of Presentation: ラルナカ(キプロス)
  • Year and Date: 2010-10-02
• [Presentation] 『温泉・温熱の先端科学をリハビリテーションへ』温熱の消化器・腎・皮膚への影響 (2010)
  • Author(s): 飯山準一
  • Organizer: 日本リハビリテーション医学会学術集会
  • Place of Presentation: 鹿児島市
  • Year and Date: 2010-05-20
• [Presentation] 熱吸入による経気道全身加温の試み (2010)
  • Author(s): 宮崎慎二,飯山準一
  • Organizer: 第75回日本温泉気候物理医学会総会
  • Place of Presentation: 那須塩原市
  • Year and Date: 2010-05-15
• [Presentation] グリセリン添加入浴の長期使用に伴う臨床効果の変化 (2009)
  • Author(s): 岩下愛梨,林丈夫,飯山準一
  • Organizer: 第20回重症心身障害療育学会学術集会
  • Place of Presentation: 小樽市
  • Year and Date: 2009-10-05
• [Presentation] グリセリン添加強酸性浴による皮膚性状変化について (2009)
  • Author(s): 飯山準一,川平和美
  • Organizer: 第74回日本温泉気候物理医学会総会
  • Place of Presentation: つくば市
  • Year and Date: 2009-05-15
• [Presentation] Effects of glycerin and strong acidic warm water bath on skin condition (2009)
  • Author(s): junichi iiyama, kazumi kawahira
  • Organizer: 5th World Congress of the International Society of Physical & Rehabilitation Medicine
  • Place of Presentation: Istanbul, Turkey
• [Presentation] A study on the supply and demand of therapists in Japan (2009)
  • Author(s): junichi iiyama
  • Organizer: 5th World Congress of the International Society of Physical & Rehabilitation Medicine
  • Place of Presentation: Istanbul, Turkey
• [Presentation] Potentiality of thermal stimulation as a novel non pharmacological therapy on internal organs (2009)
  • Author(s): Junichi Iiyama
  • Organizer: 1st International Congress of Polish Rehabilitation
  • Place of Presentation: Warszawa
• [Remarks]
  • URL: http://www.kumamoto-hsu.ac.jp/r-activity-list/r-activity-12.html
• [Patent(Industrial Property Rights)] Thermotherapy and apparatus for thermotherapy (2011)
  • Inventor(s): 飯山準一,川平和美
  • Industrial Property Rights Holder: 飯山準一,川平和美,ネクサス株式会社
  • Filing Date: 2011-02-24
  • Overseas
• [Patent(Industrial Property Rights)] Thermotherapy and apparatus for thermotherapy (2011)
  • Inventor(s): 飯山準一,川平和美
  • Industrial Property Rights Holder: 飯山準一,川平和美,ネクサス株式会社
  • Filing Date: 2011-02-24
  • Overseas
• [Patent(Industrial Property Rights)] Thermotherapy and apparatus for thermotherapy (2011)
  • Inventor(s): 飯山準一, 川平和美
  • Industrial Property Rights Holder: 飯山準一, 川平和美, ネクサス株式会社
  • Filing Date: 2011-02-09
  • Overseas
• [Patent(Industrial Property Rights)] Thermotherapy and apparatus for thermotherapy (2011)
  • Inventor(s): 飯山準一, 川平和美
  • Industrial Property Rights Holder: 飯山準一, 川平和美, ネクサス株式会社
  • Filing Date: 2011-02-09
  • Overseas