Mechanism of signal transduction in antioxidant adaptive response
| Project/Area Number |
21590287
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Kumamoto University |
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Principal Investigator |
FUJII Shigemoto 熊本大学, 大学院・生命科学研究部, 助教 (00325333)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Tatuya 熊本大学, 大学院・生命科学研究部, 助教 (30419634)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | シグナル伝達 / 酸化ストレス / 適応応答 / 8-nitro-cGMP / S-グアニル化 / シグナル伝逹 / 酸化スレス |
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| Research Abstract |
We established a method for quantification of intracellular 8-nitro-cGMP, a second messenger in antioxidant adaptive response, and revealed the involvement of mitochondria and NADPH oxidase in 8-nitro-cGMP formation in cells. We also found that S-guanylation of Keap1 by 8-nitro-cGMP, and subsequent Nrf2 activation and induction of antioxidant proteins expression, are important mechanisms in adaptive response against oxidative stress.
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Report
(4 results)
Research Products
(88 results)
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[Journal Article] Potential association of Helicobacter cinaedi with atrial arrhythmia and atherosclerosis2012
Author(s)
Khan S, Okamoto T, Enomoto K, Sakashita N, Oyama K, Fujii S, Sawa T, Takeya M, Ogawa H, Yamabe H, and Akaike T
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Journal Title
Microbiol Immunol
Volume: 56
Pages: 145-154
NAID
Related Report
Peer Reviewed
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[Journal Article] The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response2010
Author(s)
Fujii S, Sawa T, Ihara H, Tong KI, Ida T, Okamoto T, Ahmed KA, Ishima Y, Motohashi H, Yamamoto M, and Akaike T
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Journal Title
J Biol Chem
Volume: 285
Pages: 23970-23984
Related Report
Peer Reviewed
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[Presentation] Helicobacter cinaedi infection as a potential etiological factor in atrial arrhythmia and atherosclerosis. XIII International Congress of Bacteriology and Applied Microbiology2011
Author(s)
Tatsuya Okamoto, Shahzada Khan, Naomi Sakashita, Kohta Oyama, Shigemoto Fujii, Tomohiro Sawa, Motohiro Takeya, Hisao Ogawa, Kunihiko Matsui, Hiroshige Yamabe, Takaaki Akaike
Organizer
第84回日本細菌学会総会
Place of Presentation
Sapporo Convention Center, Sapporo
Related Report
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[Presentation] Role of Keap1 S-guanylation in the antioxidant adaptive response in C6 glioma cells2010
Author(s)
Shigemoto Fujii, Tomohiro Sawa, Hideshi Ihara, Tomoaki Ida, Tatsuya Okamoto, Hozumi Motohashi, Masayuki Yamamoto, Takaaki Akaike
Organizer
6th International Conference on Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
Place of Presentation
Kyoto International Conference Center, Kyoto, Japan
Related Report
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[Presentation] Detection of protein-bound 3-nitrotyrosine in plasma from pediatric patients with fulminant ARDS and avian influenza infection2010
Author(s)
Tatsuya Okamoto, Tomohiro Sawa, Shigemoto Fujii, Mie Tateyama, Shoji Kawachi, Thuy Thi Bich Phung, Liem Thanh Nguyen, Kazuo Suzuki, Takaaki Akaike
Organizer
6th International Conference on Biology, Chemistry and Therapeutic applications of Nitric Oxide
Place of Presentation
Kyoto International Conference Center, Kyoto, Japan
Related Report
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