Molecular mechanisms of oxidative stress regulation by nucleic acid nitration
| Project/Area Number |
21590312
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
SAWA Tomohiro 熊本大学, 大学院・生命科学研究部, 准教授 (30284756)
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| Co-Investigator(Kenkyū-buntansha) |
FUJII Shigemoto 熊本大学, 大学院・生命科学研究部, 助教 (00325333)
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| Co-Investigator(Renkei-kenkyūsha) |
ARIMOTO Hirokazu 東北大学, 大学院・生命科学研究科, 教授 (60262789)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 活性酸素 / シグナル伝達 / 核酸ニトロ化 / 酸化ストレス / シグナル伝逹 |
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| Research Abstract |
Inflammatory stimulation with lipopolysaccharide and cytokines remarkably augmented reactive oxygen species(ROS) production from mitochondria via activation of NADPH oxidase. Mitochondria-derived ROS together with nitric oxide(NO) induced nitration of guanine nucleotides in cells. These data suggest that guanine nitration might function as a unique sensing mechanism representing cellular status of redox homeostasis.
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Report
(4 results)
Research Products
(82 results)
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[Journal Article] Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration2012
Author(s)
Nishida M, Sawa T, Kitajima N, Ono K, Inoue H, Ihara H, Motohashi H, Yamamoto M, Suematsu M, Kurose H, van der Vliet A, Freeman BA, Shibata T, Uchida K, Kumagai Y, and Akaike T.
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Journal Title
Nature Chem Biol
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] S-Guanylation of human serum albumin is a unique posttranslational modification and results in a novel class of antibacterial agents2012
Author(s)
Ishima Y, Hoshino H, Shinagawa T, Watanabe K, Akaike T, Sawa T, Kragh-Hansen U, Kai T, Watanabe H, Maruyama T, and Otagiri M.
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Journal Title
J Pharm Sci
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Potential association of Helicobacter cinaedi with atrial arrhythmia and atherosclerosis2012
Author(s)
Khan S, Okamoto T, Enomoto K, Sakashita N, Oyama K, Fujii S, Sawa T, Takeya M, Ogawa H, Yamabe H, and Akaike T.
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Journal Title
Microbiol Immunol
Volume: 56
Pages: 145-154
Related Report
Peer Reviewed
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[Journal Article] Vascular responses to 8-nitro-cyclic GMP in nondiabetic and diabetic mice2011
Author(s)
Tokutomi Y, Kataoka K, Yamamoto E, Nakamura T, Hisato F, Nako H, Toyama K, Dong YF, Ahmed KA, Sawa T, Akaike T, and Kim-Mitsuyama S.
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Journal Title
Br J Pharmacol
Volume: 162
Pages: 1884-1893
Related Report
Peer Reviewed
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[Journal Article] The critical role of nitric oxide signaling, via proteinS-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response2010
Author(s)
Fujii S, Sawa T, Ihara H, Tong KI, Ida T, Okamoto T, Ahmed KA, Ishima Y, Motohashi H, Yamamoto M, and Akaike T.
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Journal Title
J Biol Chem
Volume: 285
Pages: 23970-23984
Related Report
Peer Reviewed
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