Modulation of mRNA splicing for the genetic diseases
| Project/Area Number |
21591365
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAUCHI Akira 川崎医科大学, 医学部, 准教授 (80372431)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 小児免疫 / アレルギー / 膠原病学 / 活性酸素 / 慢性肉芽腫症 / 好中球 |
|---|
| Research Abstract |
The gaol of this research is an analysis of transcription, post-transcription and the modulation of mRNA. This researches clarified transcriptional regulation of the phagocyte NADPH oxidase(J. Immunol. 2011, BBRC 2010) and signal transduction by oxidative stress for the cells(BBRC 2011). This reaearch further developed the method to detect superoxide quantitatively(Tropical Medicine and Health. 2011).
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Report
(4 results)
Research Products
(27 results)
