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Histological study for mechanosensitive channels in the supratarsal Mueller' s muscle of upper eyelid

Research Project

Project/Area Number 21592284
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Plastic surgery
Research InstitutionShinshu University

Principal Investigator

YUZURIHA Shunsuke  信州大学, 医学部, 准教授 (10270969)

Co-Investigator(Kenkyū-buntansha) MATSUO Kiyoshi  信州大学, 医学部, 教授 (20135156)
FUJITA Kenya  信州大学, 医学部附属病院, 講師 (00447781)
YANO Shiharu  信州大学, 医学部附属病院, 助教(診療) (10531907)
BAN Ryokuya  信州大学, 医学部, 助教 (30447784)
MISHIMA Yoshito  信州大学, 医学部附属病院, 助教(診療) (80464098)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords上眼瞼 / ミュラー筋 / 機械刺激受容 / カハール介在細胞 / ICC / 平滑筋 / 神経線維 / 免疫組織化学 / 整経線維 / 機械刺激受容チャネル / TRP
Research Abstract

Mueller's muscle is a smooth muscle tissue on the margin of eyelid. It is contracted by stimulation of the sympathetic nerve. It is not only one of the muscle elevating upper eyelid but also a mechanoreceptor to contract the levator palpebral muscle which is a main eye opening skeletal muscle innervated by oculomotor nerve. In this histological study, we found mechanosensitive channels at the nerve ending and smooth muscle cells in Mueller' s muscle. And, we also found interstitial cells of Cajal mediating neurotransmission between nerve and smooth muscle in Mueller' s muscle like in the bladder and gastrointestinal tract.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (5 results)

All 2012 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] A Contractile Network of Interstitial Cells of Cajal in the Supratarsal Mueller' s Smooth Muscle Fibers with Sparse Sympathetic Innervation2012

    • Author(s)
      Yuzuriha S、Matsuo K、Ban R、Yano S、Moriizumi T
    • Journal Title

      Plasty

      Volume: 12巻 Pages: 13-13

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Contractile Network of Interstitial Cells of Cajal in the Supratarsal Mueller's Smooth Muscle Fibers with Sparse Sympathetic Innervation2012

    • Author(s)
      Shunsuke Yuzuriha, et al
    • Journal Title

      ePlasty

      Volume: 12

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] ミュラー筋内におけるカハール介在細胞ICCの検索2010

    • Author(s)
      杠俊介
    • Organizer
      日本形成外科学会基礎学術集会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2010-09-16
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] ミュラー筋内の機械刺激受容チャネルに関する組織学的検索2009

    • Author(s)
      杠俊介
    • Organizer
      日本形成外科学会基礎学術集会
    • Place of Presentation
      都市センターホテル(東京都)
    • Year and Date
      2009-10-01
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 下眼瞼瞼板筋に分布する神経線維2009

    • Author(s)
      矢野志春
    • Organizer
      日本形成外科学会基礎学術集会
    • Place of Presentation
      都市センターホテル(東京都)
    • Year and Date
      2009-10-01
    • Related Report
      2011 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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