Molecular genetic analysis of hybrid vigor and inbreeding depression utilizing recombinant inbred mouse strains

• Project/Area Number: 21650097
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Laboratory animal science
• Research Institution: Shinshu University
• Principal Investigator: MORI Masayuki 信州大学, 医学系研究科, 准教授 (60273190)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,330,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,100,000 (Direct Cost: ¥1,100,000); Fiscal Year 2009: ¥800,000 (Direct Cost: ¥800,000)
• Keywords: リコンビナント近交系 / 雑種強勢 / 近交退化 / マウス / 遺伝解析

Research Abstract

It was revealed that the hybrid mice from genetically distant SM/J and A/J mouse strains showed superiority to the parental strains in growth and breeding performances. It was suggested that the recombinant inbred mouse strains derived from SM/J and A/J would be a valuable tool for elucidation of the mechanisms of hybrid vigor and inbreeding depression.

Research Products

• [Journal Article] ApoA-I deficiency in mice is associated with redistribution of apoA-II and aggravated AApoAII amyloidosis (2011)
  • Author(s): Wang Y., Sawashita J., Qian Z., Zhang B., Fu X., Tian G., Chen L., Mori M., Higuchi K.
  • Journal Title: Journal of Lipid Research Volume: 52巻 Issue: 8 Pages: 1461-1470
  • DOI: 10.1194/jlr.m013235
  • Peer Reviewed
• [Journal Article] Nuclear but Not Mitochondrial DNA Involvement in Respiratory Complex I Defects Found in Senescence-Accelerated Mouse Strain, SAMP8 (2011)
  • Author(s): Imanishi H., Yokota M., Mori M., Shimizu A., Nakada K., Hayashi J.
  • Journal Title: Experimental Animals Volume: 60 Issue: 4 Pages: 397-404
  • DOI: 10.1538/expanim.60.397
  • NAID: 10029550792
  • ISSN: 0007-5124, 1341-1357, 1881-7122
  • Peer Reviewed
• [Journal Article] Genes for Difference in Eosinophilic Phenotype between MES and BN.MES-Cybames Rats Are on Chromosomes 9, 5, and 1 (2011)
  • Author(s): Tomozawa H., Nishio A., Higuchi K., Matsumoto K., Mori M.
  • Journal Title: Experimental Animals Volume: 60 Issue: 2 Pages: 151-160
  • DOI: 10.1538/expanim.60.151
  • NAID: 10029550320
  • ISSN: 0007-5124, 1341-1357, 1881-7122
  • Peer Reviewed
• [Journal Article] The reduced form of Coenzyme Q10 mediates distinct effects on cholesterol metabolism at the transcriptional and metabolite level in SAMP1 mice (2010)
  • Author(s): Schmelzer C., Okun J., Haas D., Higuchi K., Sawashita J., Mori M., Doring F.
  • Journal Title: IUBMB Life Volume: 62巻 Issue: 11 Pages: 812-818
  • DOI: 10.1002/iub.388
  • Peer Reviewed
• [Journal Article] Mouse senile amyloid fibrils deposited in skeletal muscle exhibit amyloidosis-enhancing activity (2010)
  • Author(s): Qian J., Yan J., Ge F., Zhang B., Fu X., Tomozawa H., Sawashita J., Mori M., Higuchi K.
  • Journal Title: PLoS Pathogen Volume: 6巻 Issue: 5 Pages: 1000914-1000914
  • DOI: 10.1371/journal.ppat.1000914
  • NAID: 120007110474
  • Peer Reviewed
• [Journal Article] Mouse model to study human Aβ2M amyloidosis : Generation of transgenic mouse with excessive expression of humanβ2-microglobulin (2010)
  • Author(s): Zhang P., Fu X., Sawashita J., Yao J., Zhang B., Qian J., Tomozawa H., Mori M., Ando Y., Higuchi K.
  • Journal Title: Amyloid Volume: 17巻 Issue: 2 Pages: 50-62
  • DOI: 10.3109/13506129.2010.483116
  • Peer Reviewed
• [Journal Article] Mouse model to study human A β 2M amyloidosis : Generation of transgenic mouse with excessive expression of human β 2-microglobulin (2010)
  • Author(s): Zhang P., Fu X., Sawashita J., Yao J., Zhang B., Qian J., Tomozawa H., Mori M., Ando Y., Higuchi K.
  • Journal Title: Amylid Volume: 17 Pages: 50-62
  • Peer Reviewed
• [Journal Article] The reduced form of Coenzyme Q10 mediates distinct effects on chol esterol metabolism at the transcriptional and metabolite level in SAMPL mice (2010)
  • Author(s): Schmelzer C., Okun J., Haas D ., Higuchi K., Sawashita J., M on M., Doring F.
  • Journal Title: IUBMB Life Volume: 62 Pages: 812-818
  • Peer Reviewed
• [Journal Article] Supplementation with the reduced form of Coenzyme Q10 decelerates phenotypic characteristics of senescence and induces a PPAR-αgene expression signature in SAMP1 mice (2009)
  • Author(s): Schmelzer C., Kubo H., Mori M., Sawashita J., Kitano M., Hosoe K., Boomgaarden I., Doring F., Higuchi K
  • Journal Title: Molecular Nutrition & Food Research Volume: 54巻 Issue: 6 Pages: 1-11
  • DOI: 10.1002/mnfr.200900155
  • Peer Reviewed
• [Journal Article] Dysfunction in ABCB1A has only a weak effect on susceptibility to dextran sulfate sodium-induced colitis in SAM strains (2009)
  • Author(s): Zhang G., Fu X., Takeda T., Higuchi K., Mori M
  • Journal Title: Experimental Animals Volume: 58巻 Pages: 421-425
  • NAID: 130000122250
  • Peer Reviewed
• [Journal Article] Dysfunction in ABCB1A has only a weak effect on susceptibility to dextran sulfate sodium-induced colitis in SAM strains (2009)
  • Author(s): Zhang G., Fu X., Takeda T., Higuchi K., Mori M.
  • Journal Title: Experimental Animals 58 Pages: 421-425
  • NAID: 130000122250
  • Peer Reviewed
• [Journal Article] Supplementation with the reduced form of Coenzyme Q10 decelerates phenotypic characteristics of senescence and induces a PPAR-α gene expression signature in SAMP1 mice (2009)
  • Author(s): Schmelzer C., Kubo H., M., Sawashita J., Kitano M., Hosoe K., Boomgaarden I., Doring F., Higuchi K.
  • Journal Title: Molecular Nutrition & Food Research 54 Pages: 1-11
  • Peer Reviewed
• [Presentation] 白内障の分子遺伝学的機序-動物モデルを中心に- (2010)
  • Author(s): 森政之
  • Organizer: 日本白内障学会49回総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-06-25
• [Presentation] モデル生物研究の重要性 (2009)
  • Author(s): 森政之
  • Organizer: 日本遺伝学会第81回大会公開市民講座「遺伝学と社会の接点第2部:パネル討論会現代社会における遺伝学の教育と普り方」
  • Place of Presentation: 松本
  • Year and Date: 2009-09-16
• [Presentation] 老化促進モデルマウス(SAMP)の現状と遺伝的特性 (2009)
  • Author(s): 樋口京一、森政之、竹田俊男
  • Organizer: 第56回日本実験動物学会シンポジウム「モデルマウスを用いた老化への分子遺伝学的アプローチ」
  • Place of Presentation: さいたま
  • Year and Date: 2009-05-14
• [Remarks]
  • URL: http://www.shinshu-u.ac.jp/faculty/medicine/department/doctor/grdkarei/i-byotai/
• [Remarks]
  • URL: http://www.shinshu-u.ac.jp/faculty/medicine/department/doctor/grdkarei/i-byotai/