| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
1) We developed the knockout mice of two isozymes of phosphatidylinositol 4-phosphate 5-kinases (PIP5K_A and PIP5K_B), which are phospholipid metabolizing enzymes to synthesize phosphatidylinositol 4,5-bisphosphate (PIP_2). From the analyses of these knockout mice, we found that PIP5K_A and PIP5K_B are crucial for spermatogenesis. 2) We also found that phosphatidylethanolamine and its synthetic enzyme, ethanolamine kinase-1, play an important role in neurite elongation.
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