|Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
RNA-binding proteins coordinate protein expression through post-transcriptional regulations. We demonstrated that hnRNPK localizes in Stress Granules and has a role for the regulation of ATP level during stress condition through RNA regulation. Furthermore, we revealed that RBM42, an hnRNPK binding protein, functions in the regulation of ATP synthesis. We also obtained evidences that hnRNPK and RBM42 coordinate cell proliferation by regulating novel target mRNAs.