Regulation of the onset of neuronal migration in the developing mouse neocortex
| Project/Area Number |
21770230
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ITOH Yasuhiro The University of Tokyo, 分子細胞生物学研究所, 助教 (50508108)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 細胞分化 / ニューロン / 細胞移動 / 神経発生 / 大脳新皮質 |
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| Research Abstract |
During the neocortical development, neural precursor cells are located in the ventricular zone by attaching their apical process to the ventricular surface through cadherin-based adherens junctions and form a pseudostratified epithelial structure. Once these cells commit to become neurons or intermediate neuronal progenitors, they delaminate and start migration toward the pial surface. However, it has remained unclear how the detachment from the neuroepithelium, the first step of radial migration, is coordinated with neuronal fate commitment. This study revealed a mechanism that links these two processes.
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Report
(3 results)
Research Products
(6 results)
