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MicroRNA-9 Regulates Neurogenesis in Mouse Telencephalon by Targeting Multiple Transcription Factors

Research Project

Project/Area Number 21770248
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Developmental biology
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

SHIBATA Mikihito  The Institute of Physical and Chemical Research, ボディプラン研究グループ, 研究員 (50391975)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsマウス / 発生 / 端脳 / 大脳新皮質 / microRNA-9 / Foxg1 / Cajal-Retzius cells / corticogenesis / subcorticogenesis / Gsh2 / Brn2 / Meis2 / Islet1 / 細胞増殖 / TCA
Research Abstract

microRNA-9-2 and microRNA-9-3 double-mutant mice demonstrate that microRNA-9 (miR-9) controls neural progenitor proliferation and differentiation in the developing telencephalon by regulating the expression of multiple transcription factors. Also we found that the activity of miR-9 is finely modulated by AU-rich RNA-binding proteins and Msi1 during development.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2011 2010 2009 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (11 results)

  • [Journal Article] MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription Factors2011

    • Author(s)
      Mikihito Shibata, Hiromi Nakao, Hiroshi Kiyonari, Takaya Abe, Shinichi Aizawa
    • Journal Title

      The Journal of Neuroscience 31(9)

      Pages: 3407-3422

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors

    • Author(s)
      Mikihito Shibata
    • Journal Title

      The journal of Neuroscience

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] MicroRNA-9 regulates neural progenitor proliferation and differentiation in both pallium and subpallium by targeting Foxg1, Nr2e1, Gsh2 and Meis22010

    • Author(s)
      Mikihito Shibata, Hiromi Nakao, Hiroshi Kiyonari, Takaya Abe, Shinichi Aizawa
    • Organizer
      69^<th> Annual Meeting of Society for Developmental Biology.
    • Place of Presentation
      Albuquerque, New Mexico, USA
    • Year and Date
      2010-08-07
    • Related Report
      2010 Final Research Report
  • [Presentation] MicroRNA-9 regulates neural progenitor proliferation and differentiation in both pallium and subpallium by targeting Foxg1, Nr2e1, Gsh2 and Meis22010

    • Author(s)
      Mikihito Shibata
    • Organizer
      69^<th> Annual Meeting of Society for Developmental Biology
    • Place of Presentation
      Albuquerque, New Mexico, USA
    • Year and Date
      2010-08-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] microRNA-9 is regulates neural progenitor proliferation and differentiation in both pallium and subpallium by targeting Foxg1, Nr2e1, Gsh2, Meis2, and Islet12010

    • Author(s)
      Mikihito Shibata, Hiromi Nakao, Hiroshi Kiyonari, Takaya Abe, Shinichi Aizawa
    • Organizer
      2^<nd> Joint Meeting of the French and JapaneseSociety for Developmental Biology.
    • Place of Presentation
      Institute Pasteur, Paris France
    • Year and Date
      2010-05-27
    • Related Report
      2010 Final Research Report
  • [Presentation] microRNA-9 is regulates neural progenitor proliferation and differentiation in both pallium and subpallium by targeting Foxg1, Nr2e1, Gsh2, Meis2, and Islet12010

    • Author(s)
      Mikihito Shibata
    • Organizer
      2^<nd> Joint Meeting of the French and Japanese Society for Developmental Biology
    • Place of Presentation
      Institute Pasteur, Paris France
    • Year and Date
      2010-05-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] microRNA-9 is required for neurogenesis and axon pathfinding in mouse telencephalon through the regulation of Foxg1, Nr2e1, Gsh2, Meis2, and Islet12010

    • Author(s)
      Mikihito Shibata, Hiromi Nakao, Hiroshi Kiyonari, Takaya Abe, Shinichi Aizawa
    • Organizer
      19^<th> CDB Meeting RNA Science in Cell and Developmental Biology.
    • Place of Presentation
      Kobe, Japan.
    • Year and Date
      2010-05-11
    • Related Report
      2010 Final Research Report
  • [Presentation] microRNA-9 is required for neurogenesis and axon pathfinding in mouse telencephalon through the regulation of Foxg1, Nr2e1, Gsh2, Meis2, and Islet12010

    • Author(s)
      Mikihito Shibata
    • Organizer
      19^<th> CDB Meeting RNA Science in Cell and Developmental Biology
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2010-05-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] MicroRNA-9 targets Foxg1, Nr2e1, and Meis2 for neurogenesis in mouse telencephalon2010

    • Author(s)
      柴田幹士
    • Organizer
      2010 Keystone Symposia
    • Place of Presentation
      Keystone Resort Keystone, Colorado, USA
    • Year and Date
      2010-01-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] microRNA-9 is essential for the neurogenesis and morphogenesis in the mouse neocortex development2010

    • Author(s)
      Mikihito Shibata, Hiromi Nakao, Hiroshi Kiyonari, Takaya Abe, Shinichi Aizawa
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology.
    • Place of Presentation
      Keystone, Colorado, USA
    • Year and Date
      2010-01-15
    • Related Report
      2010 Final Research Report
  • [Presentation] MicroRNA-9 regulates early neurogenesis and morphogenesis in mouse telencephalon2009

    • Author(s)
      柴田幹士
    • Organizer
      16^<th> International Society of Developmental Biologists Congress 2009
    • Place of Presentation
      EICC Edinburgh
    • Year and Date
      2009-09-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] MicroRNA-9 regulates early neurogenesis and morphogenesis in mouse telencephalon2009

    • Author(s)
      柴田幹士
    • Organizer
      Society for Developmental Biology 68^<th> Annual Meeting
    • Place of Presentation
      Hyatt Regency, San Francisco
    • Year and Date
      2009-07-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Early neurogenesis and corticogenesis are impaired in mice telencephalon lacking microRNA-92009

    • Author(s)
      柴田幹士
    • Organizer
      42^<nd> Annual Meeting for the Japanese Society of Developmental Biology
    • Place of Presentation
      新潟朱鷺メッセ
    • Year and Date
      2009-05-29
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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