MicroRNA-9 Regulates Neurogenesis in Mouse Telencephalon by Targeting Multiple Transcription Factors
| Project/Area Number |
21770248
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SHIBATA Mikihito The Institute of Physical and Chemical Research, ボディプラン研究グループ, 研究員 (50391975)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | マウス / 発生 / 端脳 / 大脳新皮質 / microRNA-9 / Foxg1 / Cajal-Retzius cells / corticogenesis / subcorticogenesis / Gsh2 / Brn2 / Meis2 / Islet1 / 細胞増殖 / TCA |
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| Research Abstract |
microRNA-9-2 and microRNA-9-3 double-mutant mice demonstrate that microRNA-9 (miR-9) controls neural progenitor proliferation and differentiation in the developing telencephalon by regulating the expression of multiple transcription factors. Also we found that the activity of miR-9 is finely modulated by AU-rich RNA-binding proteins and Msi1 during development.
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Report
(3 results)
Research Products
(13 results)
