MicroRNA-9 Regulates Neurogenesis in Mouse Telencephalon by Targeting Multiple Transcription Factors

• Project/Area Number: 21770248
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Developmental biology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: SHIBATA Mikihito The Institute of Physical and Chemical Research, ボディプラン研究グループ, 研究員 (50391975)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: マウス / 発生 / 端脳 / 大脳新皮質 / microRNA-9 / Foxg1 / Cajal-Retzius cells / corticogenesis / subcorticogenesis / Gsh2 / Brn2 / Meis2 / Islet1 / 細胞増殖 / TCA

Research Abstract

microRNA-9-2 and microRNA-9-3 double-mutant mice demonstrate that microRNA-9 (miR-9) controls neural progenitor proliferation and differentiation in the developing telencephalon by regulating the expression of multiple transcription factors. Also we found that the activity of miR-9 is finely modulated by AU-rich RNA-binding proteins and Msi1 during development.

Research Products

• [Journal Article] MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription Factors (2011)
  • Author(s): Mikihito Shibata, Hiromi Nakao, Hiroshi Kiyonari, Takaya Abe, Shinichi Aizawa
  • Journal Title: The Journal of Neuroscience 31(9) Pages: 3407-3422
  • Peer Reviewed
• [Journal Article] MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors
  • Author(s): Mikihito Shibata
  • Journal Title: The journal of Neuroscience Volume: (in press)
  • Peer Reviewed
• [Presentation] MicroRNA-9 regulates neural progenitor proliferation and differentiation in both pallium and subpallium by targeting Foxg1, Nr2e1, Gsh2 and Meis2 (2010)
  • Author(s): Mikihito Shibata, Hiromi Nakao, Hiroshi Kiyonari, Takaya Abe, Shinichi Aizawa
  • Organizer: 69^<th> Annual Meeting of Society for Developmental Biology.
  • Place of Presentation: Albuquerque, New Mexico, USA
  • Year and Date: 2010-08-07
• [Presentation] MicroRNA-9 regulates neural progenitor proliferation and differentiation in both pallium and subpallium by targeting Foxg1, Nr2e1, Gsh2 and Meis2 (2010)
  • Author(s): Mikihito Shibata
  • Organizer: 69^<th> Annual Meeting of Society for Developmental Biology
  • Place of Presentation: Albuquerque, New Mexico, USA
  • Year and Date: 2010-08-07
• [Presentation] microRNA-9 is regulates neural progenitor proliferation and differentiation in both pallium and subpallium by targeting Foxg1, Nr2e1, Gsh2, Meis2, and Islet1 (2010)
  • Author(s): Mikihito Shibata, Hiromi Nakao, Hiroshi Kiyonari, Takaya Abe, Shinichi Aizawa
  • Organizer: 2^<nd> Joint Meeting of the French and JapaneseSociety for Developmental Biology.
  • Place of Presentation: Institute Pasteur, Paris France
  • Year and Date: 2010-05-27
• [Presentation] microRNA-9 is regulates neural progenitor proliferation and differentiation in both pallium and subpallium by targeting Foxg1, Nr2e1, Gsh2, Meis2, and Islet1 (2010)
  • Author(s): Mikihito Shibata
  • Organizer: 2^<nd> Joint Meeting of the French and Japanese Society for Developmental Biology
  • Place of Presentation: Institute Pasteur, Paris France
  • Year and Date: 2010-05-27
• [Presentation] microRNA-9 is required for neurogenesis and axon pathfinding in mouse telencephalon through the regulation of Foxg1, Nr2e1, Gsh2, Meis2, and Islet1 (2010)
  • Author(s): Mikihito Shibata, Hiromi Nakao, Hiroshi Kiyonari, Takaya Abe, Shinichi Aizawa
  • Organizer: 19^<th> CDB Meeting RNA Science in Cell and Developmental Biology.
  • Place of Presentation: Kobe, Japan.
  • Year and Date: 2010-05-11
• [Presentation] microRNA-9 is required for neurogenesis and axon pathfinding in mouse telencephalon through the regulation of Foxg1, Nr2e1, Gsh2, Meis2, and Islet1 (2010)
  • Author(s): Mikihito Shibata
  • Organizer: 19^<th> CDB Meeting RNA Science in Cell and Developmental Biology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-05-11
• [Presentation] MicroRNA-9 targets Foxg1, Nr2e1, and Meis2 for neurogenesis in mouse telencephalon (2010)
  • Author(s): 柴田幹士
  • Organizer: 2010 Keystone Symposia
  • Place of Presentation: Keystone Resort Keystone, Colorado, USA
  • Year and Date: 2010-01-17
• [Presentation] microRNA-9 is essential for the neurogenesis and morphogenesis in the mouse neocortex development (2010)
  • Author(s): Mikihito Shibata, Hiromi Nakao, Hiroshi Kiyonari, Takaya Abe, Shinichi Aizawa
  • Organizer: Keystone Symposia on Molecular and Cellular Biology.
  • Place of Presentation: Keystone, Colorado, USA
  • Year and Date: 2010-01-15
• [Presentation] MicroRNA-9 regulates early neurogenesis and morphogenesis in mouse telencephalon (2009)
  • Author(s): 柴田幹士
  • Organizer: 16^<th> International Society of Developmental Biologists Congress 2009
  • Place of Presentation: EICC Edinburgh
  • Year and Date: 2009-09-10
• [Presentation] MicroRNA-9 regulates early neurogenesis and morphogenesis in mouse telencephalon (2009)
  • Author(s): 柴田幹士
  • Organizer: Society for Developmental Biology 68^<th> Annual Meeting
  • Place of Presentation: Hyatt Regency, San Francisco
  • Year and Date: 2009-07-24
• [Presentation] Early neurogenesis and corticogenesis are impaired in mice telencephalon lacking microRNA-9 (2009)
  • Author(s): 柴田幹士
  • Organizer: 42^<nd> Annual Meeting for the Japanese Society of Developmental Biology
  • Place of Presentation: 新潟朱鷺メッセ
  • Year and Date: 2009-05-29