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Regulatory roles for the functional network of placenta on maintenance of homeostasis during pregnancy

Research Project

Project/Area Number 21780089
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Applied biochemistry
Research InstitutionUniversity of Tsukuba

Principal Investigator

ISHIDA Junji  University of Tsukuba, 大学院・生命環境科学研究科, 講師 (30323257)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords妊娠高血圧 / 胎盤 / 情報伝達 / アンジオテンシン / 遺伝子操作マウス
Research Abstract

To clarify the regulatory roles for the functional network of placenta on maintenance of homeostasis during normal pregnancy, I used full genome expression profiling to characterize the placenta of pregnant mice at a molecular level. The dynamic changes in the expression levels of metabolism- and neoangiogenesis-related genes were identified. On the other hand, in human, it is assumed that pregnancy-induced hypertension (PIH) is resulting from the breakdown of the pregnancy homeostasis. In this study, I showed that pregnancy-associated hypertensive (PAH) mice, which were previously generated in our laboratory, exhibited the pathological condition including the criteria of PIH. In addition, by evaluating the ameliorative properties of the antihypertensive drugs in PAH mice, I demonstrated the effectiveness of blockade of AT1, a receptor of vasopressor angiotensin II, on prevention of this pregnancy-related disease.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (24 results)

All 2010 2009 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (15 results) Book (6 results) Remarks (1 results)

  • [Journal Article] Role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase2009

    • Author(s)
      Araya, N., Arimura, H., Kawahara, K., Yagishita, N., Ishida, J., 他12名
    • Journal Title

      Int.J.Mol.Med. 24

      Pages: 605-611

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase2009

    • Author(s)
      Araya, N.
    • Journal Title

      Int.J.Mol.Med. 24

      Pages: 605-611

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 妊娠高血圧マウスの臓器障害に対するAT1受容体阻害の改善効果2010

    • Author(s)
      石田純治、中村匠子、深水昭吉
    • Organizer
      第33回日本高血圧学会
    • Place of Presentation
      福岡県、福岡国際会議場
    • Year and Date
      2010-10-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 血管平滑筋特異的APJ受容体過剰発現マウスにおける血管収縮制御メカニズムの解明2010

    • Author(s)
      永野克将、石田純治、松倉頼、深水昭吉
    • Organizer
      第33回日本高血圧学会
    • Place of Presentation
      福岡県、福岡国際会議場
    • Year and Date
      2010-10-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 妊娠高血圧マウスの臓器障害に対するAT1受容体阻害の改善効果2010

    • Author(s)
      石田純治
    • Organizer
      第33回 日本高血圧学会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血管平滑筋特異的APJ受容体過剰発現による血管収縮制御機構の解明2010

    • Author(s)
      永野克将、石田純治、海野まどか、松倉頼、粕谷善俊、村尾命、木村健二郎、望月直樹、深水昭吉
    • Organizer
      第1回Molecular Cardiovascular Conference II
    • Place of Presentation
      北海道、小樽ホテルピアノ
    • Year and Date
      2010-09-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Impaired Placental Neovascularization in Mice with Pregnancy-Associated Hypertension2010

    • Author(s)
      Junji Ishida, Mitsuko Furuya, Saki Inaba, Yoshitoshi Kasuya, Sadao Kimura, Ryoichi Nemori, Akiyoshi Fukamizu
    • Organizer
      International Symposium on Cardiovascular Endocrinology and Metabolism CVEM 2010
    • Place of Presentation
      Nara, Nara Prefectural New Public Hall
    • Year and Date
      2010-04-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Enhanced apelin-induced hypotension by endothelial overexpression of APJ2010

    • Author(s)
      Kazuya Murata, Junji Ishida, Yumiko Noguchi, Taku Iguchi, Akira Sakairi, Shiro Nishiwaki, Naoto Masui, Tatsuo Hashimoto, Satoshi Umemura, Akiyoshi Fukamizu
    • Organizer
      International Symposium on Cardiovascular Endocrinology and Metabolism CVEM 2010
    • Place of Presentation
      Nara, Nara Prefectural New Public Hall
    • Year and Date
      2010-04-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Effect of APJ deficiency on diet-induced insulin resistance2010

    • Author(s)
      Katsumasa Nagano, Junji Ishida, Yasumi Hashimoto, Mei Murao, Kenjiro Kimura, Yoshitoshi Kasuya, Fumihiro Sugiyama, Ken-ichi Yagami, Akiyoshi Fukamizu
    • Organizer
      International Symposium on Cardiovascular Endocrinology and Metabolism CVEM 2010
    • Place of Presentation
      Nara, Nara Prefectural New Public Hall
    • Year and Date
      2010-04-01
    • Related Report
      2010 Final Research Report
  • [Presentation] Impaired Placental Neovascularization in Mice with Pregnancy-Associated Hypertension2010

    • Author(s)
      石田純治
    • Organizer
      International Symposium on Cardiovascular Endocrinology and Metabolism, CVEM 2010
    • Place of Presentation
      奈良県新公会堂(奈良県)
    • Year and Date
      2010-04-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Impaired Placental Neovascularization in Mice with Pregnancy-Associated Hypertension2010

    • Author(s)
      石田純治
    • Organizer
      International Symposium on Cardiovascular Endocrinology and Metabolism 2010
    • Place of Presentation
      奈良(奈良県)
    • Year and Date
      2010-03-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] 食餌誘導型インスリン抵抗性に対するAPJ受容体欠損の影響2010

    • Author(s)
      石田純治
    • Organizer
      第4回炎症・脂質代謝・メタボ リサーチフォーラム
    • Place of Presentation
      東京(東京都)
    • Year and Date
      2010-02-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 妊娠高血圧マウスの心臓リモデリングに対するAT1受容体阻害の改善効果2009

    • Author(s)
      石田純治
    • Organizer
      第13回 日本心血管内分泌代謝学会
    • Place of Presentation
      大宮(埼玉県)
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 妊娠高血圧症モデルマウスにおける胎盤構造障害に関する研究2009

    • Author(s)
      石田純治
    • Organizer
      第32回 日本高血圧学会
    • Place of Presentation
      大津(滋賀県)
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 妊娠高血圧症モデルマウスの胎盤における血管構造障害に関する研究2009

    • Author(s)
      石田純治
    • Organizer
      第13回 Molecular Cardiovascular Conference
    • Place of Presentation
      小樽(北海道)
    • Year and Date
      2009-09-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 妊娠高血圧症モデルマウスにおける胎盤の血管構造変化に関する研究2009

    • Author(s)
      石田純治
    • Organizer
      第30回 日本妊娠高血圧学会
    • Place of Presentation
      岡山(岡山県)
    • Year and Date
      2009-08-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 妊娠高血圧マウス胎盤における血管構造障害に関する研究2009

    • Author(s)
      石田純治
    • Organizer
      平成21年度 日本生化学会関東支部例会
    • Place of Presentation
      つくば(茨城県)
    • Year and Date
      2009-06-20
    • Related Report
      2009 Annual Research Report
  • [Book] The Lipid(「レニン・アンジオテンシノーゲンノックアウトマウス」)2010

    • Author(s)
      石田純治、深水昭吉
    • Total Pages
      21
    • Publisher
      メディカルビュー社
    • Related Report
      2010 Final Research Report
  • [Book] Annual Review 循環器2010(「Apelin-APJ シグナルと動脈硬化」)2010

    • Author(s)
      濱田樹理、石田純治、深水昭吉
    • Publisher
      中外医学社
    • Related Report
      2010 Final Research Report
  • [Book] The Lipid「レニン・アンジオテンシノーゲン ノックアウトマウス」2010

    • Author(s)
      石田純治
    • Publisher
      メディカルレビュー社
    • Related Report
      2009 Annual Research Report
  • [Book] Annual Review 循環器2010「Apelin-APJシグナルと動脈硬化」2010

    • Author(s)
      濱田樹理
    • Publisher
      中外医学社
    • Related Report
      2009 Annual Research Report
  • [Book] 日本臨床「高血圧上」(「レニン・アンジオテンシン系遺伝子欠損マウス:遺伝子改変動物に関する最新知見」)2009

    • Author(s)
      村田知弥、石田純治、深水昭吉
    • Total Pages
      67
    • Publisher
      日本臨床社
    • Related Report
      2010 Final Research Report
  • [Book] 高血圧 上「レニン・アンジオテンシン系遺伝子欠損マウス」2009

    • Author(s)
      村田知弥
    • Publisher
      日本臨床社
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://akif2.tara.tsukuba.ac.jp/

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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