2010 Fiscal Year Final Research Report
Regulatory roles for the functional network of placenta on maintenance of homeostasis during pregnancy
| Project/Area Number |
21780089
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied biochemistry
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| Research Institution | University of Tsukuba |
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Principal Investigator |
ISHIDA Junji University of Tsukuba -> 筑波大学, 大学院・生命環境科学研究科, 講師 (30323257)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 妊娠高血圧 / 胎盤 / 情報伝達 / アンジオテンシン / 遺伝子操作マウス |
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| Research Abstract |
To clarify the regulatory roles for the functional network of placenta on maintenance of homeostasis during normal pregnancy, I used full genome expression profiling to characterize the placenta of pregnant mice at a molecular level. The dynamic changes in the expression levels of metabolism- and neoangiogenesis-related genes were identified. On the other hand, in human, it is assumed that pregnancy-induced hypertension (PIH) is resulting from the breakdown of the pregnancy homeostasis. In this study, I showed that pregnancy-associated hypertensive (PAH) mice, which were previously generated in our laboratory, exhibited the pathological condition including the criteria of PIH. In addition, by evaluating the ameliorative properties of the antihypertensive drugs in PAH mice, I demonstrated the effectiveness of blockade of AT1, a receptor of vasopressor angiotensin II, on prevention of this pregnancy-related disease.
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Research Products
(11 results)
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[Journal Article] Role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase2009
Author(s)
Araya, N., Arimura, H., Kawahara, K., Yagishita, N., Ishida, J., 他12名
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Journal Title
Int.J.Mol.Med. 24
Pages: 605-611
Peer Reviewed
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[Presentation] Enhanced apelin-induced hypotension by endothelial overexpression of APJ2010
Author(s)
Kazuya Murata, Junji Ishida, Yumiko Noguchi, Taku Iguchi, Akira Sakairi, Shiro Nishiwaki, Naoto Masui, Tatsuo Hashimoto, Satoshi Umemura, Akiyoshi Fukamizu
Organizer
International Symposium on Cardiovascular Endocrinology and Metabolism CVEM 2010
Place of Presentation
Nara, Nara Prefectural New Public Hall
Year and Date
2010-04-01
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[Presentation] Effect of APJ deficiency on diet-induced insulin resistance2010
Author(s)
Katsumasa Nagano, Junji Ishida, Yasumi Hashimoto, Mei Murao, Kenjiro Kimura, Yoshitoshi Kasuya, Fumihiro Sugiyama, Ken-ichi Yagami, Akiyoshi Fukamizu
Organizer
International Symposium on Cardiovascular Endocrinology and Metabolism CVEM 2010
Place of Presentation
Nara, Nara Prefectural New Public Hall
Year and Date
2010-04-01
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