Characterization of intestinal barrier defect in metabolic syndrome and the ameliorative effect of food factors
| Project/Area Number |
21780117
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Hiroshima University |
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Principal Investigator |
SUZUKI Takuya Hiroshima University, 大学院・生物圏科学研究科, 講師 (30526695)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 栄養科学 / メタボリックシンドローム / 消化管バリア機能 / タイトジャンクション |
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| Research Abstract |
Studies using animal and cell culture models were conducted to investigate the mechanism(s) underlying the intestinal barrier defects in metabolic syndrome. The barrier defect was induced in the small intestines of the diet-induced obese rats, which was associated with the decreases in the tight junction protein expression. The experiment using the cultured intestinal cells showed that the barrier defect was induced by excessive dietary lipid and subsequent bile juice secretion.
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Report
(3 results)
Research Products
(5 results)
