Regulation of intestinal symbiotic system and inflammatory reactions by food
| Project/Area Number |
21780133
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Nihon University |
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Principal Investigator |
TAKAHASHI Kyoko Nihon University, 生物資源科学部, 講師 (70366574)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 腸管上皮細胞 / マスト細胞 / 腸内細菌 / 腸管免疫系 / 上皮細胞 / 炎症反応 |
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| Research Abstract |
Interaction of intestinal commensal bacteria with mast cells and epithelial cells was analyzed. It was shown that intestinal commensal bacteria affect the terminal differentiation of mast cells and they regulate expression of the genes which are involved in recognition of microbes in intestinal epithelial cells. These mechanisms underlying modulation of the functions of mast cells and intestinal epithelial cells by commensal bacteria may provide a useful target for the regulation of inflammatory reactions which are caused by the disorder of intestinal homeostasis.
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Report
(3 results)
Research Products
(85 results)
