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Expression analysis of endogenous retroviral elements in canine malignant tumors.

Research Project

Project/Area Number 21780288
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Clinical veterinary science
Research InstitutionYamaguchi University

Principal Investigator

BABA Kenji  Yamaguchi University, 農学部, 助教 (90452367)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords内在性レトロウイルス / 悪性腫瘍 / 犬 / イヌ / 悪性黒色腫 / 腫瘍
Research Abstract

An endogenous retroviral envelope gene was newly identified in canine genome. The predicted amino acid sequence indicated that the retroviral element belonged to the genus Betaretrovirus and encoded a functional envelope protein. The expression of the envelope mRNA was shown in canine malignant melanoma cell lines. This study indicated that the newly identified retroviral envelope may be a tumor antigen in canine malignant melanoma.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (12 results)

All 2011 2010 2009 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Identification of novel endogenous betaretroviruses which are transcribed in the bovine placenta.2011

    • Author(s)
      Baba K, Nakaya Y, Shojima T, Muroi Y, Kizaki Y, Hashizume K, Imakawa K, Miyazawa T.
    • Journal Title

      Journal of Virology 85(3)

      Pages: 1237-1245

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adaptation of feline immunodeficiency virus subtype B strain TM2 to a feline astrocyte cell line (G355-5 cells).2011

    • Author(s)
      Ishikawa M
    • Journal Title

      Veterinary Microbiology

      Volume: 149(3-4) Pages: 307-315

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel endogenous betaretroviruses which are transcribed in the bovine placenta.2011

    • Author(s)
      Baba K
    • Journal Title

      Journal of Virology

      Volume: 85(3) Pages: 1237-1245

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Susceptibility and production of a feline endogenous retrovirus (RD-114 virus) in various feline cell lines.2011

    • Author(s)
      Okada M
    • Journal Title

      Virus Research

      Volume: 155(1) Pages: 268-273

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential Diagnosis of Feline Leukemia Virus Subgroups Using Pseudotype Viruses Expressing Green Fluorescent Protein.2010

    • Author(s)
      Nakamura M
    • Journal Title

      The Journal of Veterinary Medical Science (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antiviral activity of membrane fusion inhibitors that target gp40 of the feline immunodeficiency virus envelope protein.2009

    • Author(s)
      Mizukoshi F
    • Journal Title

      Veterinary Microbiology 136(1-2)

      Pages: 155-159

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of hematological abnormalities and detection of infected bone marrow cells in asymptomatic cats with feline immunodeficiency virus infection.2009

    • Author(s)
      Fujino Y
    • Journal Title

      Veterinary Microbiology 36(3-4)

      Pages: 217-225

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of monocyte-derived dendritic cells from cats infected with feline immunodeficiency virus.2009

    • Author(s)
      Mizukoshi F
    • Journal Title

      The Journal of Veterinary Medical Science 71(7)

      Pages: 865-871

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 見落としがちな感染症~診断のポイント~2010

    • Author(s)
      馬場健司
    • Organizer
      日本獣医内科学アカデミー/日本獣医臨床病理学会 2010年大会
    • Place of Presentation
      京王プラザホテル、東京
    • Year and Date
      2010-02-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification of Novel Bovine Endogenous Retrovirus Envelopes and Putative Accessory Proteins.2009

    • Author(s)
      Baba K, Shojima T, Miyazawa T.
    • Organizer
      21st International Workshop on Retroviral Pathogenesis
    • Place of Presentation
      Italy Ciocco Hotel and Rerort Lucca.
    • Year and Date
      2009-09-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Identification of Novel Bovine Endogenous Retrovirus Envelopes and Putative Accessory Proteins.2009

    • Author(s)
      Baba K
    • Organizer
      21st International Workshop on Retroviral Pathogenesis
    • Place of Presentation
      Il Ciocco Hotel and Resort, Lucca, Italy
    • Year and Date
      2009-09-14
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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