Control of axial chirality and development of novel bioactive compounds with asymmetric axes.
| Project/Area Number |
21790025
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Teikyo University |
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Principal Investigator |
TABATA Hidetsugu Teikyo University, 薬学部, 助手 (80445634)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 動的キラリティー / 軸不斉 / ビアリール骨格 / アトロプ異性体 / カップリング反応 |
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| Research Abstract |
The dibenzo[b,d]azepin-6-one nucleus, which constitutes the scaffold of the γ-secretase inhibitors LY-411575 and its analogs, has two sp^2-sp^2 asymmetric axes. We are interested in stereochemistry of the two asymmetric axes, and have reported the atropisomeric properties of dibenzo[b,d]azepin-6-one derivatives. Herein, we present a study on the stereochemistry of the eight-membered analog, dibenzo[b,d]azocin-6-one derivatives.
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Report
(3 results)
Research Products
(15 results)
