Signal transductions of R-Ras family GTPases

• Project/Area Number: 21790069
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Kyoto University
• Principal Investigator: OINUMA Izumi Kyoto University, 大学院・生命科学研究科, 助教 (40452297)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: シグナル伝達 / 神経科学 / R-Ras / H-Ras / TC21 / neuron / axon / dendrite / Myosin / integrin / 細胞接着

Research Abstract

We have identified roles of R-Ras family of small GTPases, which functions downstream of the repulsive axon guidance molecule, semaphorin and its receptor, Plexin.

Research Products

• [Journal Article] Semaphorin 4D/plexin-B1 stimulates PTEN activity through R-Ras GTPase-activating protein activity, inducing growth cone collapse in hippocampal neurons. (2010)
  • Author(s): Izumi Oinuma, Yuri Ito, Hironori Katoh, Manabu Negishi
  • Journal Title: J.Biol.Chem. 285 Pages: 28200-28209
  • Peer Reviewed
• [Journal Article] Semaphorin 4D/plexin-B1 stimulates PTEN activity through R-Ras GTPase-activating protein activity, inducing growth cone collapse in hippocampal neurons (2010)
  • Author(s): Izumi Oinuma, Yuri Ito, Hironori Katoh, Manabu Negishi
  • Journal Title: J.Biol.Chem. Volume: 285 Pages: 28200-28209
  • Peer Reviewed
• [Journal Article] Plexin-B1 is a GTPase activating protein for M-Ras, remodelling dendrite morphology. (2009)
  • Author(s): Yasuhiro Saito, Izumi Oinuma, Satoshi Fujimoto, Manabu Negishi.
  • Journal Title: EMBO Rep 10 Pages: 614-621
  • Peer Reviewed
• [Journal Article] Plexin-B1 is a GTPase activating protein for M-Ras, remodeling dendrite morphology. (2009)
  • Author(s): Yasuhiro Saito, Izumi Oinuma, Hironori Katoh, Manabu Negishi
  • Journal Title: EMBO reports 10 Pages: 614-621
  • Peer Reviewed
• [Presentation] M-Rasの新奇エフェクターであるLamellipodinはアクチン骨格系の制御により樹状突起伸長を制御するLamellipodin, a novel effector of M-Ras, regulates the dendritic maturation through reconstructing actin network (2010)
  • Author(s): 田坂元一、生沼泉、根岸学
  • Organizer: BMB2010
  • Place of Presentation: 神戸国際会議場(招待講演)
  • Year and Date: 2010-12-10
• [Presentation] Molecular mechanism of integrin activation by R-Ras (2009)
  • Author(s): 生沼泉、根岸学
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2009-10-23
• [Presentation] 神経回路形成へのナビゲーション (2009)
  • Author(s): 生沼泉
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2009-10-22
• [Presentation] M-Rasの新奇エフェクターであるLamellipodinはアクチン骨格系の制御により樹状突起伸長を制御する
  • Author(s): 田坂元一、生沼泉、根岸学
  • Organizer: Lamellipodin, a novel effector of M-Ras, regulates the dendritic maturation through reconstructing actin network
• [Book] ブレインサイエンスレビュー (2010)
  • Author(s): 伊藤正男、川合述史、水島昇、生沼泉、大島登志男、太田訓正、船越洋、柳川右千男、森吉弘毅、佐藤純、浜千尋、長谷川功、鎌田恭輔、三澤日出巳
  • Total Pages: 263
  • Publisher: クバプロ出版
• [Book] ブレインサイエンスレビュー2010 (2010)
  • Author(s): 伊藤正男、川合述史、水島昇、生沼泉、大島登志男、太田訓正、船越洋、柳川右千男、森吉弘毅、佐藤純、浜千尋、長谷川功、鎌田恭輔、三澤日出巳
  • Publisher: クバプロ
• [Remarks] ホームページ等研究成果は以下のホームページに掲載している。
  • URL: http://www.users.kudpc.kyoto-u.ac.jp/~p51907/negishi/index.html
• [Remarks]
  • URL: http://www.users.kudpc.kyoto-u.ac.jp/~p51907/negishi/index.html
• [Remarks]
  • URL: http://www.users.kudpc.kyoto-u.ac.jp/~p51907/negishi/index.html