Development and clinical application of biomarker for predicting the sensitivity to chemotherapeutic agents
| Project/Area Number |
21790168
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Himeji Dokkyo University |
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Principal Investigator |
TAKARA Kohji Himeji Dokkyo University, 薬学部, 准教授 (00329939)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | オーダーメード医療 / 癌 / 薬剤反応性 / マイクロアレイ / バイオマーカー |
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| Research Abstract |
Eight genes, which were correlated negatively with the IC50 values for platinum derivatives, were extracted by a microarray analysis. In contrast, 48 genes were extracted, which showed the positive correlation with the IC50 values for platinum derivatives. The level of BRCA1/2 expression showed a positive correlation with the IC50 values for cisplatin, and that for 5-FU showed a positive correlation with the levels of MRP2 and MRP5 expression. In addition, proteome analysis indicated that 200 or 156 protein was expressed highly or low in the low-sensitive cells, respectively. Among them, the regulators for homeostasis of iron and for detoxification of heavy metal, were included.
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Report
(3 results)
Research Products
(9 results)
