Development of peptide molecules that can regulate melanoma stem cells
| Project/Area Number |
21790238
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Chiba University |
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Principal Investigator |
SUGANAMI Akiko 千葉大学, 大学院・医学研究院, 特任研究員 (10527922)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 創薬 / ゲノム薬理学 / 悪性黒色腫 / 癌幹細胞 / IL-10 / ペプチド分子標的薬 / コンピュータ・シミュレーション / 細胞内局在 |
|---|
| Research Abstract |
The malignant melanoma is a kind of the skin cancer with high malignancy. Furthermore, it is easy to metastasize to brain, lung and liver. In this study, I utilized the in silico molecular evolution system. It is a computer simulation system that was developed in our laboratory for the creation of peptide drugs. I already created some peptide molecules that is expected to be effective for the treatment of the malignant melanoma. In addition, I constructed a new drug delivery system (DDS) that employed liposome as a main component.
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Report
(4 results)
Research Products
(4 results)
