| Project/Area Number |
21790256
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Fukuoka University |
|---|
Principal Investigator |
KIYA Yoshihiro Fukuoka University, 医学部, 助手 (60534998)
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|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | HDL / 心筋梗塞 / 左室リモデリング / 左室リモデング |
|---|
| Research Abstract |
Wistar rats were divided into three groups : Sham, and myocardial infarction rats model that injected placebo (MI group) or rHDL (6mg/kg, MI+rHDL group). The MI+rHDL group increased LV ejection fraction and expression of ERK, Rb and decreased fibrotic area of MI compared to that in the MI group. In addition, rHDL suppressed arrest of cell growth in myocytes. This effect was blocked by PD98059, an ERK inhibitor. In conclusions, rHDL has beneficial effects that prevent LV remodeling, and may prevent arrest of cell growth through ERK pathway in myocytes.
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