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Analysis of silencing mechanism of INK4A gene expression during tumorigenesis with in vivo imaging system

Research Project

Project/Area Number 21790332
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pathological medical chemistry
Research InstitutionJapanese Foundation For Cancer Research

Principal Investigator

YAMAKOSHI Kimi  Japanese Foundation For Cancer Research, 癌研究所がん生物部, 研究員 (50423398)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords分子腫瘍学 / 癌抑制遺伝子 / p16 / インビボ・イメージング / エピジェネティクス / 皮膚化学発癌 / P16
Research Abstract

To elucidate molecular mechanisms of p16^<INK4a> gene silencing during tumorigenesis, we used bioluminescence imaging for non-invasive and real-time analysis of p16^<INK4a> expression under various physiological conditions in living mice. As a result, we discovered that oncogenic insults, such as Ras activation, provoke epigenetic de-repression of p16^<INK4a> expression through reduction of DNMT1 level as a DNA damage response in vivo.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (17 results)

All 2011 2010 2009 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (5 results) Book (3 results) Remarks (2 results)

  • [Journal Article] Intrinsic cooperation between p16^<INK4a> and p21^<Waf1/Cip1> in the onset of cellular senescence and tumor suppression in vivo.2010

    • Author(s)
      Takeuchi, S., Takahashi, A., Motoi, N., Yoshimoto, S., Tajima, T., Yamakoshi, K., Hirao, A., Yanagi, S., Fukami, K., Ishikawa, Y., Sone, S., Hara, E., Ohtani, N.
    • Journal Title

      Cancer Res. 15,70(22)

      Pages: 9381-9390

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 細胞老化研究の最前線2010

    • Author(s)
      山越貴水、原英二
    • Journal Title

      メディカル・サイエンス・ダイジェスト Vol.36

    • Related Report
      2010 Final Research Report
  • [Journal Article] Real-time in vivo imaging of p16 gene expression : a new approach to study senescence stress signaling in living animals.2010

    • Author(s)
      Ohtani, N., Yamakoshi, K., Takahashi, A., Hara, E.
    • Journal Title

      Cell.Div. 14,5

      Pages: 1-1

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intrinsic cooperation between p16^<INK4a> and p21^<Waf1/Cip1> in the onset of cellular senescence and tumor suppression in vivo.2010

    • Author(s)
      Takeuchi Shinji
    • Journal Title

      Cancer Research

      Volume: 70 Pages: 9381-9390

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Real-time in vivo imaging of p16 gene expression : a new approach to study senescence stress signaling in living animals.2010

    • Author(s)
      Ohtani Naoko
    • Journal Title

      Cell Division

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Real-time in vivo imaging of p16^<INK4a> reveals cross talk with p53.2009

    • Author(s)
      Yamakoshi, K., Takahashi, A., Hirota, F., Nakayama, R., Ishimaru, N., Kubo, Y., Mann, DJ., Ohmura, M., Hirao, A., Saya, H., Arase, S., Hayashi, Y., Nakao, K., Matsumoto, M., Ohtani, N., Hara, E.
    • Journal Title

      J.Cell Biol. 10,186(3)

      Pages: 393-407

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Real-time in vivo imaging of p16^<INK4a> reveals cross talk with p532009

    • Author(s)
      Kimi Yamakoshi
    • Journal Title

      The Journal of Cell Biology 186

      Pages: 393-407

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Backup tumor suppressor role for p16^<INK4a> in the event of p53 inactivation2010

    • Author(s)
      山越貴水
    • Organizer
      日本分子生物学会年回・日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Real-time in vivo imaging of p16^<Ink4a> gene expression unveils the dynamics of tumor suppressor network pathway in living animals.2010

    • Author(s)
      山越貴水
    • Organizer
      The 16th Takeda Science Foundation Symposium on Bioscience
    • Place of Presentation
      Sheraton Miyako Hotel(東京都)
    • Year and Date
      2010-12-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Backup tumor suppressor role for p16^<Ink4a> in the event of p53 inactivation.2010

    • Author(s)
      Akiko Takahashi, Kimi Yamakoshi, Naoko Ohtani, Eiji Hara.
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同学会
    • Place of Presentation
      神戸(特別講演)
    • Year and Date
      2010-01-02
    • Related Report
      2010 Final Research Report
  • [Presentation] Real-time In Vivo Imaging of p16^<INK4a> Expression Unveils a Cross-talk between p53 and p16^<INK4a>2009

    • Author(s)
      山越貴水
    • Organizer
      Mechanisms & Models of Cancer Meeting
    • Place of Presentation
      Salk Institute(アメリカ合衆国カリフォルニア州ラ・ホヤ市)
    • Year and Date
      2009-08-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] Real-time in vivo imaging of p16^<Ink4a> expression unveils a cross-talk between p53 and p16^<Ink4a>.2009

    • Author(s)
      Kimi Yamakoshi, Akiko Takahashi, Naoko Ohtani, Eiji Hara.
    • Organizer
      2nd Salk Institute, Mechanisms and Models of Cancer meeting
    • Place of Presentation
      アメリカ合衆国カリフォルニア州ラ・ホヤ市(一般演題)
    • Related Report
      2010 Final Research Report
  • [Book] インビボイメージングによる細胞老化誘導遺伝子p16^<INK4a>及びp53の機能解析、モデル動物利用マニュアル(仮題)2011

    • Author(s)
      山越貴水、原英二
    • Publisher
      発刊予定
    • Related Report
      2010 Final Research Report
  • [Book] モデル動物利用マニュアル2011

    • Author(s)
      山越貴水
    • Publisher
      株式会社 エル・アイ・シー(仮題 発刊予定)
    • Related Report
      2010 Annual Research Report
  • [Book] Medical Science Digest2010

    • Author(s)
      山越貴水
    • Total Pages
      4
    • Publisher
      ニュー・サイエンス社
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.jfcr.or.jp/tci/canbio/publication/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.jfcr.or.jp/tci/canbio/publication/index.html

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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