New Tyrosine kinase inhibitor for thyroid medullary carcinoma treatment
Project/Area Number |
21790395
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Experimental pathology
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Research Institution | Aichi Medical University |
Principal Investigator |
KAWAI Kumi 愛知医科大学, 医学部, 講師 (50362231)
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Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 甲状腺がん / RET / 遺伝子操作動物 / チロシンキナーゼインヒビター / 癌 / 甲状腺髄様がん / キナーゼ阻害剤 / モデルマウス |
Research Abstract |
The purpose of this study was to demonstrate the effect of 2 new tyrosine kinase inhibitors against RET. Both drug inhibited RET phosphorylation and downstream signaling cascade in a dose-dependent manner. Furthermore, they suppressed cell growth, cell migration and invasion effectively. When medullary thyroid carcinoma model mice was treated with these drugs, significant reduction in thyroid tumor size was observed.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Ret finger protein inhibits muscle differentiation by modulating serum response factor and enhancer of polycomb12011
Author(s)
Hae Jin Kee, Ju-Ryoung Kim, Hosouk Joung, Nakwon Choe, Song Eun Lee, Gwang Hyeon Eom, Jeong Chul Kim, Stefan H Geyer, Mayumi Jijiwa, Takuya Kato, Kumi Kawai, Wolfgang J Weninger, Sang-Beom Seo, Kwang-Il Nam, Myung Ho Jeong, Masahide Takahashi and Hyun Kook
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Journal Title
Cell Death Differ
Volume: 19
Pages: 121-131
Related Report
Peer Reviewed
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[Journal Article] Loss of Sprouty2 partially rescues renal hypoplasia and stomach hypoganglionosis but not intestinal aganglionosis in Ret Y1062F mutant mice2011
Author(s)
Rieko Miyamoto, Mayumi, Jijiwa, Masato Asai, Kumi Kawai, Maki Ishida-Takagishi, Shinji Mii, Naoya Asai, Atsushi Enomoto, Yoshiki Murakumo, Akihiko Yoshimura and Masahide Takahashi
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Journal Title
Developmental Biololgy
Volume: 349
Pages: 160-168
Related Report
Peer Reviewed
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