Control of tumor formation after transplantation in regenerative therapy with genetic engineering methods

• Project/Area Number: 21790528
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied pharmacology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: TAHARA Tsuyoshi The Institute of Physical and Chemical Research, 分子プローブ機能評価研究チーム, 研究員 (20419708)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 再生医療 / がん / HSV-TK / 癌

Research Abstract

Gene therapy and cell transplantation therapy is expected to be a breakthrough for treating neurodegenerative disorders, such as Parkinson's and Alzheimer's disease. In this study, I could isolate the tumor- or non-differentiated cell-specific promoter region from Oct3/4 gene promoter and make the GFP expression vector, which works only in non-differentiated cell, such as mouse embryonic EB5 cell but not mouse fibroblast Balb/3T3b cells.