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Elusidation of a regulatory mechanism by Peroxiredoxin 6 (Prx-6) in inflammatory bowel desease(IBD

Research Project

Project/Area Number 21790680
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

OKADA Hitomi  Kyoto Prefectural University of Medicine, 医学研究科, 助教(寄附講座) (60533023)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords腸管炎症性疾患 / 酸化ストレス
Research Abstract

It is suggested that Peroxiredoxin 6 (Prx-6) may provide cytoprotection and wound healing in YAMC cells. Ulcerative colitis (UC) patients were treated using granulocytapheresis (GCAP). After the treatment, Prx6 in the patients, which observed the therapeutic effect, increased. These results show that Prx-6 may be involved in mechanisms of inflammatory bowel disease (IBD) and be used as a marker of examination the therapeutic effect of IBD.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (3 results)

All 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] Identification of inflammation-related proteins in a murine colitis model by 2D fluorescence difference gel electrophoresis and mass spectrometry2010

    • Author(s)
      内藤裕二、高木智久、岡田ひとみ、藤分秀司、吉川敏一
    • Journal Title

      Journal of Gastroenterology and Hepatology Suppl.1

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of inflammation-related proteins in a murine colitis model by 2D fluorescence difference gel electrophoresis and mass spectrometry2010

    • Author(s)
      内藤裕二、高木智久、岡田ひとみ, 藤分秀司、吉川敏一
    • Journal Title

      Journal of Gastroenterology and Hepatology Suppl. 1

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 炎症性腸疾患における抗酸化酵素Peroxiredoxin-VIの役割2010

    • Author(s)
      高木智久、岡田ひとみ
    • Organizer
      第63回日本酸化ストレス学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-06-24
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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