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Identification of the important factor of GM-CSF sensitized dendritic cells that involves with the process of antitumor effect induced by GM-CSF

Research Project

Project/Area Number 21790773
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionKyushu University

Principal Investigator

TANAKA Yoshihiro  Kyushu University, 病院先端分子・細胞治療科, 学術研究員 (30536850)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsGM-CSF / 樹状細胞 / センダイウイルスベクター / 肺癌 / センダイウィルスベクター
Research Abstract

To identify the mechanism of antitumor effect induced by s.c. administration of GM-CSF gene transduced LLC (LLC/SeV/GM) cells, we conducted cDNA microarray analysis by using GM-CSF-sensitized DCs harvested from tumor-derived lymph nodes. The result showed that the genes involved in type I interferons-producing DCs (plasmacytoid DCs; pDCs), upon activation, were robustly upregulated in GM-DCs compared with its counterpart. Furthermore, the results of both in vivo depletion of pDCs and s.c. co-administration of TLR7 agonist with LLC/SeV/GM cells indicated that pDCs plays central roles on the antitumor effect induced by GM-CSF.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (3 results)

All 2011 2010 Other

All Presentation (2 results) Remarks (1 results)

  • [Presentation] Comparative microarray analysis implicates the pivotal participation of Type I Interferon related signaling pathway in antitumor effect provoked by in vivo GM-CSF gene transduced lung cancer cells2011

    • Author(s)
      Megumi Narusawa, Hiroyuki Inoue, Yoshihiro Tanaka, Yosuke Yokota, Chika Sakamoto, Shohei Miyamoto, Tomoko Inoue, Makoto Inoue, Koichi Takayama, Mamoru Hasegawa, Yoichi Nakanishi, Kenzaburo Tani
    • Organizer
      ASGCT 14th Annual Meeting
    • Place of Presentation
      SEATTLE, WA.(採録決定済)
    • Related Report
      2010 Final Research Report
  • [Presentation] Comparable transcriptional profile of murine mature dendritic cells in draining lymph node during tumor rejection by non-transmissible Sendai virus encoding GM-CSF infection2010

    • Author(s)
      成澤慈、井上博之、田中芳浩、横田洋介、坂本千香、宮本将平、井上朋子、井上誠、長谷川護、谷憲三朗
    • Organizer
      第33回日本分子生物学会年会第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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