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Skin barrier dysfunction and asthma

Research Project

Project/Area Number 21790786
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionKeio University

Principal Investigator

WAKAKI Misa  慶應義塾大学, 医学部, 共同研究員 (30338032)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords気管支喘息 / 皮膚バリア / 抗原感作 / 気道過敏性 / 経皮感作 / バリア機能障害 / 喘息モデル / インターロイキン17 / インターロイキン23
Research Abstract

Allergen sensitization through a disrupted skin barrier plays a prominent role in the development of atopic diseases, including allergic asthma. The present study has clarified that skin-mediated allergen sensitization results in the prolonged airway inflammation and bronchial hyper-responsiveness in IL-23/IL-17-dependent manner.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (10 results)

All 2011 2010 2009

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (7 results)

  • [Journal Article] Strain-specific phenotypes of airway inflammation and bronchial hyperresponsiveness induced by epicutaneous allergen sensitisation in BALB/c and C57BL/6 mice2010

    • Author(s)
      M. Kodama, K. Asano, T. Oguma, S. Kagawa, K. Tomomatsu, M. Wakaki, T. Takihara, S. Ueda, N. Ohmori, H. Ogura, J. Miyata, K. Tanaka, N. Kamiishi, K. Fukunaga, K. Sayama, E. Ikeda, T. Miyasho, A. Ishizaka
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 152 Pages: 67-74

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Strain-specific phenotypes of airway inflammation and bronchial responsiveness in duced by epicutaneous allergen sensitization in Balb/c and C57BL/6 mice2010

    • Author(s)
      Motohiro Kodama, Misa Wakaki, et.al.
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 152 Pages: 67-74

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strain-specific phenotypes of airway inflammation and bronchial responsiveness in duced bv epicutaneous allergen sensitization in Balb/c and C57BL/6 mice2010

    • Author(s)
      Motohiro Kodama, Misa Wakaki, et. al.
    • Journal Title

      Int Arch Allergy Immunol 152(in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Prolonged airway inflammation and responsiveness in mice sensitized via the skin is IL-23-dependent2011

    • Author(s)
      K Asano, M Kodama, M Wakaki, S Kagawa, T Oguma, K Fukunaga, Y Suzuki, K Sayama, D Cua
    • Organizer
      ATS 2011 International Conference
    • Place of Presentation
      Denver, USA
    • Year and Date
      2011-05-16
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 経皮抗原感作による遷延性気道炎症・過敏性亢進とIL-17/IL-232011

    • Author(s)
      樹神元博、鈴木雄介、小熊剛、若木美佐、加川志津子、加畑宏樹、上石修史、田中希宇人、宮田純、小倉裕美、友松克允、福永興壱、佐山宏一、浅野浩一郎
    • Organizer
      第51回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 経皮抗原感作マウスにおける気道炎症と気道過敏性亢進の遷延2010

    • Author(s)
      樹神元博、若木美佐, 他
    • Organizer
      第60回日本アレルギー学会総会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 経皮抗原感作マウスにおける気道炎症と気道過敏性亢進の遷延2010

    • Author(s)
      樹神元博、小熊剛、加川志津子、加畑宏樹、上石修史、田中希宇人、宮田純、小倉裕美、友松克允、若木美佐、塩見哲也、福永興壱、佐山宏一、浅野浩一郎
    • Organizer
      第60回日本アレルギー学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 経皮抗原感作喘息モデルマウスの検討2009

    • Author(s)
      樹神元博、浅野浩一郎、小熊剛、加川志津子、若木美佐、友松克充, 小倉裕美, 宮田純, 堀内奈緒, 上田壮一郎、佐山宏一、石坂彰敏
    • Organizer
      アレルギー好酸球研究会2009
    • Place of Presentation
      東京
    • Year and Date
      2009-06-19
    • Related Report
      2011 Final Research Report
  • [Presentation] 経皮抗原感作喘息モデルマウスの作成2009

    • Author(s)
      樹神元博、浅野浩一郎、小熊剛、加川志津子、宮田純、小倉裕美、友松克允、堀内奈緒、上田壮一郎、滝原崇久、加行淳子、新美京子、若木美佐、福永興壱、佐山宏一、石坂彰敏
    • Organizer
      第49回日本呼吸器学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-06-12
    • Related Report
      2011 Final Research Report
  • [Presentation] 経皮抗原感作喘息モデルマウスの作成2009

    • Author(s)
      樹神元博、若木美佐, 他
    • Organizer
      日本呼吸器学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2009-06-12
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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