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The mechanism of cell death of macrophages by Nocardia infection

Research Project

Project/Area Number 21790791
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionShowa University (2010)
National Institute of Infectious Diseases (2009)

Principal Investigator

ISHINO Keiko  Showa University, 薬学部, 准教授 (50332359)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords細菌感染 / マクロファージ / 細胞死 / 遺伝子発現 / 感染症 / 細菌
Research Abstract

To investigate the molecular mechanism of the cell death in macrophage cells by Nocardia infection, we examined the gene expression of host cells by the microaaray system when wild-type or cytotoxicity-negative mutant strain infected macrophage cells. We showed that some cell adhesion molecules related to the cell death of macrophages by Nocardia infection.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2011 2010 2009 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (8 results) Remarks (3 results)

  • [Journal Article] Identification of nocobactin NA biosynthetic gene clusters in Nocardia farcinica.2011

    • Author(s)
      Hoshino Y, Chiba K, Ishino K, Fukai T, Igarashi Y, Yazawa K, Mikami Y, Ishikawa J.
    • Journal Title

      J Bacteriol. 93

      Pages: 441-448

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of nocobactin NA biosynthetic gene clusters in Nocardia farcinica2011

    • Author(s)
      Hoshino Y., et al
    • Journal Title

      The Journal of Bacteriology

      Volume: 193 Pages: 441-448

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 病原性放線菌ノカルジアltsA遺伝子産物の機能解析2011

    • Author(s)
      石野敬子、渋谷健太、星野泰隆、石川淳
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Related Report
      2010 Final Research Report
  • [Presentation] 病原性放線菌ノカルジア1tsA遺伝子産物の機能解析2011

    • Author(s)
      石野敬子
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] ltsA遺伝子のノカルジアの病原性への関与2010

    • Author(s)
      石野敬子、渋谷健太、星野泰隆、石川淳
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] 病原性放線菌Nocardia farcinicaのアミノグリコシド耐性機構の解明2010

    • Author(s)
      藤井匠子、石野敬子、千葉和宏、石川淳
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 1tsA遺伝子のノカルジアの病原性への関与2010

    • Author(s)
      石野敬子
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 病原性放線菌ノカルジア病原性へのノコバクチンの関与2009

    • Author(s)
      石野敬子、星野泰隆、千葉和宏、平井明香、石川淳
    • Organizer
      第29回日本細菌学会関東支部総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Nocobactin production is required for virulence of Nocardia farcinica2009

    • Author(s)
      Ishino, K., Hoshino, Y., Chiba, K., Hirai, A., Ishikawa, J.
    • Organizer
      15th International Symposium on the Biology of Actinomycetes.
    • Place of Presentation
      Shanghai, China.
    • Related Report
      2010 Final Research Report
  • [Presentation] Nocobactin production is required for virulence of Nocardia farcinica2009

    • Author(s)
      Ishino, K
    • Organizer
      15th International Symposium on the Biology of Actinomycetes
    • Place of Presentation
      Shanghai,China
    • Related Report
      2009 Annual Research Report
  • [Remarks] Nocardia farcinica Genome Project Page : ホームページ等

    • URL

      http://nocardia.nih.go.jp/

    • Related Report
      2010 Final Research Report
  • [Remarks] Nocardia farcinica Genome Project Page

    • URL

      http://nocardia.nih.go.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks] Nocardia farcinica Genome Project Page

    • URL

      http://nocardia.nih.go.jp/

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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