Prospective Study of Delayed Encephalopathy from Carbon Monoxide Poisoning
Project/Area Number |
21790849
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Neurology
|
Research Institution | Kitasato University |
Principal Investigator |
IDE Toshimitsu Kitasato University, 医学部, 講師 (00316978)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 神経病態免疫学 / 一酸化炭素中毒 / 遅発性脳症 / 脳脊髄液 / S-100B蛋白 / インターロイキン6 / サイトカイン |
Research Abstract |
The aims of this study were to clear the mechanisms and to find out the early prognostic markers of delayed encephalopathy from carbon monoxide poisoning. The delayed encephalopathy may occur with one third of severe poisoned patients, and the symptoms are variable neuropsychological phenomena. It has been no reliable prognostic markers of delayed encephalopathy. In my study of 39 poisoned patients, I showed that the early elevation of interleukin-6 concentration in cerebrospinal fluid was the best prognostic marker of delayed encephalopathy, and also the early elevation of S100B protein concentration in cerebrospinal fluid was a good prognostic marker of persistent vegetative state.
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Report
(3 results)
Research Products
(9 results)