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Investigation of effect of GIGYF2 on signal transduction

Research Project

Project/Area Number 21790856
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neurology
Research Institution財団法人東京都医学研究機構 (2010)
National Center of Neurology and Psychiatry (2009)

Principal Investigator

HIGASHI Shinji  財団法人東京都医学研究機構, 東京都精神医学総合研究所, 研究員 (30365647)

Co-Investigator(Renkei-kenkyūsha) ISEKI Eu  順天堂大学, 医学部, 教授 (30203061)
MOORE Darren  ローザンヌ工科大学, ブレインマインド研究所, 准教授
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords神経分子病態学 / パーキンソン病 / 神経変性 / GIGYF2 / インスリンシグナル / Grb10
Research Abstract

GIGYF2 has been reported as a candidate gene for PARK11-linked Parkinson's disease (PD). GIGYF2 was widely expressed, most highly in the pancreas and testis, and moderately in brain. GIGYF2 was present in Rab4-positive endosomes. Expression of GIGYF2 altered insulin-like growth factor-1 (IGF-1) receptor trafficking and enhanced IGF-1-induced ERK1/2 activation. We failed to find any differences in IGF-1-induced signaling between cells expressing wild-type and mutant GIGYF2 and observed only minimal expression of GIGYF2 in the nigrostriatal pathway, indicating no contribution of GIGYF2 to the pathogenesis of PD.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (16 results)

All 2011 2010 2009

All Journal Article (12 results) (of which Peer Reviewed: 8 results) Presentation (4 results)

  • [Journal Article] Localization of MAP1-LC3 in vulnerable neurons and Lewy bodies brains patients with dementia bodies.2011

    • Author(s)
      Higashi S, Moore DJ, Minegishi M, Kasanuki K, Fujishiro H, Kabuta T, Togo Katsuse O, Uchikado Furukawa Y, Hino Kosaka Sato Arai Wada Iseki E.
    • Journal Title

      Journal Neuropathology Experimental Neurology. 70巻

      Pages: 264-280

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] レビー小体型認知症と遺伝要因2011

    • Author(s)
      東晋二、井関栄三
    • Journal Title

      老年精神医学雑誌 22巻

      Pages: 93-98

    • Related Report
      2010 Final Research Report
  • [Journal Article] Localization of MAP1-LC3 in vulnerable neurons and Lewy bodies in brains of patients with dementia with Lewy bodies2011

    • Author(s)
      Shinji Higashi, 他
    • Journal Title

      Journal of Neuropathology and Experimantal Neurology

      Volume: 70 Pages: 264-280

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] レビー小体型認知症と遺伝要因2011

    • Author(s)
      東晋二, 他
    • Journal Title

      老年精神医学雑誌

      Volume: 22 Pages: 93-98

    • Related Report
      2010 Annual Research Report
  • [Journal Article] TDP-43 physically interacts with Amyotrophic lateral sclerosis-linked mutant CuZn superoxide dismutase.2010

    • Author(s)
      Higashi S, Tsuchiya Y, Araki T, Wasa K,Kabuta T.
    • Journal Title

      Neurochemistry international. 57巻

      Pages: 906-913

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 妄想性障害と若年性認知症をどう診分けるか-レビー小体病を中心に-2010

    • Author(s)
      東晋二、井関栄三
    • Journal Title

      精神科治療学 25巻

      Pages: 1305-1309

    • Related Report
      2010 Final Research Report
  • [Journal Article] GIGYF2 is present in endosomal compartments in the mammalian enhances compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation.2010

    • Author(s)
      Higashi S, Iseki E,Minegishi M,Togo T, Kabuta T, Wada K.
    • Journal Title

      Neurochemistry. 115巻

      Pages: 423-437

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation2010

    • Author(s)
      Shinji Higashi, 他
    • Journal Title

      Journal of Neurochemistry

      Volume: 115 Pages: 423-437

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TDP-43 physically interacts with amyotrophic lateral sclerosis-linked mutant CuZn superoxide dimustase2010

    • Author(s)
      Shinji Higashi, 他
    • Journal Title

      Neurochemistry International

      Volume: 57 Pages: 906-913

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 妄想性障害と若年性認知症をどう診分けるか-レビー小体病を中心に-2010

    • Author(s)
      東晋二, 他
    • Journal Title

      精神科治療学

      Volume: 25 Pages: 1305-1309

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Abnormal localization of LRRK2 to the endosomal-lysosomal compartment in Lewy body disease.2009

    • Author(s)
      Higashi S, Moore DJ, Yamamoto R, Minegishi M, Sato K, Togo T, Katsuse O, Uchikado H,Furukawa Y, Hino H,Kosaka K, Emson PC, Wada K,Dawson VL, Dawson TM, Arai H, Iseki E.
    • Journal Title

      Journal of Neuropathology and Experimental Neurology 68巻

      Pages: 994-1005

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal localization of Leucine-Rich Repeat Kinase 2 to the Endosomal-Lysosomal Compartment in Lewy Body Disease2009

    • Author(s)
      Shinji Higashi, 他
    • Journal Title

      Journal of Neuropathology and Experimantal Neurology 68

      Pages: 994-1005

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation.2010

    • Author(s)
      Higashi s, et al.
    • Organizer
      14^th European Federation of Neurological Societies (EFNS) Congress.
    • Place of Presentation
      スイスジュネーブPalexpo Congress Centre
    • Year and Date
      2010-09-26
    • Related Report
      2010 Final Research Report
  • [Presentation] GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation2010

    • Author(s)
      Shinji Higashi, 他
    • Organizer
      14^<th> European Federation of Neurological Societies (EFNS) Congress
    • Place of Presentation
      Geneva, Switzerland
    • Related Report
      2010 Annual Research Report
  • [Presentation] レビー小体型認知症患者剖検脳におけるLRRK2のエンドソームコンパートメントへ局在2009

    • Author(s)
      東晋二, 他
    • Organizer
      第50回本神経病理学会
    • Place of Presentation
      香川県高松市サンポートホール高松・かがわ国際議場
    • Year and Date
      2009-06-06
    • Related Report
      2010 Final Research Report
  • [Presentation] レビー小体型認知症患者剖検脳におけるLRRK2のエンドソームコンパートメントへの局在2009

    • Author(s)
      東晋二, 他
    • Organizer
      日本神経病理学会総会学術研究会
    • Place of Presentation
      サンポートホール高松(香川県高松市)
    • Year and Date
      2009-06-06
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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