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The analysis of the stress response on glycemic control in liver

Research Project

Project/Area Number 21790869
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Metabolomics
Research InstitutionKinki University

Principal Investigator

NAKAMURA Kyoko  Kinki University, 医学部, 助教 (10512197)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords糖尿病 / 肝臓代謝 / ストレス / IGFBP-1 / グルココルチコイド / 肝糖代謝
Research Abstract

In this study, we analyzed the gene expression of hormone and stress related factors in liver. We found (1) down-expression of insulin-like growth factor-1 (IGF-1), (2,3) up-expression of IGF binding protein-1 (IGFBP-1) and 11β-hydroxysteroid dehydrogenase-1 (11β-HSD1), (4) the down-expression of ER stress marker and (5) the up-expression of glucagon-like peptide-1 (GLP-1) receptor in liver of type 2 diabetic model mice under the conditions of fasting and refeeding.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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