2010 Fiscal Year Final Research Report
The analysis of the stress response on glycemic control in liver
| Project/Area Number |
21790869
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Kinki University |
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Principal Investigator |
NAKAMURA Kyoko Kinki University -> 近畿大学, 医学部, 助教 (10512197)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 糖尿病 / 肝臓代謝 / ストレス / IGFBP-1 / グルココルチコイド |
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| Research Abstract |
In this study, we analyzed the gene expression of hormone and stress related factors in liver. We found (1) down-expression of insulin-like growth factor-1 (IGF-1), (2,3) up-expression of IGF binding protein-1 (IGFBP-1) and 11β-hydroxysteroid dehydrogenase-1 (11β-HSD1), (4) the down-expression of ER stress marker and (5) the up-expression of glucagon-like peptide-1 (GLP-1) receptor in liver of type 2 diabetic model mice under the conditions of fasting and refeeding.
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