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Anti-MR(mineralocorticoid receptor) effect of dihydropyridine Ca channel blocker.

Research Project

Project/Area Number 21790897
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Endocrinology
Research InstitutionKeio University

Principal Investigator

KURIHARA Isao  慶應義塾大学, 医学部, 講師 (90338038)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords高血圧 / アルドステロン(ミネラルコルチコイド) / ステロイドホルモン受容体 / Ca拮抗薬 / 循環器・高血圧 / ジヒドロピリジン系Ca拮抗薬 / ミネラルコルチコイド受容体
Research Abstract

The study revealed that anti-MR effect of dihydropyridine Ca channel blocker(dpCCB) can be observed in vivo(in human). We also demonstrated that dpCCB antagonized not only MR but also other steroid hormone receptors such as glucocorticoid receptor and progesterone receptor partly and in diverse manner. This finding should have great impact as a translational research in that dpCCB is one of the most commonly used antihypertensives and we demonstrated a novel beneficial aspect of this agents.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (16 results)

All 2011 2010 2009

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (11 results)

  • [Journal Article] Coactivation of SF-1-Mediated Transcription of Steroidogenic Enzymes by Ubc9 and PIAS12011

    • Author(s)
      Suda N, Shibata H, Kurihara I, Ikeda Y, Kobayashi S, Yokota K, Murai-Takeda A, Nakagawa K, Oya M, Murai M, Rainey WE, Saruta T, Itoh H
    • Journal Title

      Endocrinology

      Volume: 152(6) Pages: 2266-77

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Coactivation of SF-1-Mediated Transcription of Steroidogenic Enzymes by Ubc9 and PIAS1.2011

    • Author(s)
      Suda N, Shibata H, Kurihara I, et al
    • Journal Title

      Endocrinology

      Volume: Epub

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NF-YC functions as a corepressor of agonist-bound mineralocorticoid receptor2010

    • Author(s)
      Murai-Takeda A, Shibata H, Kurihara I, Kobayashi S, Yokota K, Suda N, Mitsuishi Y, Jo R, Kitagawa H, Kato S, Saruta T, Itoh H
    • Journal Title

      J Biol Chem

      Volume: 285(11) Pages: 8084-93

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gastrointestinal pseudo-obstruction after debulking surgery of malignant pheochromocytoma, improved by intravenous administration of alpha-adrenergic receptor blocker, phentolamine2010

    • Author(s)
      Yamaguchi S, Shibata H, Miyashita K, Kurihara I, Murai-Takeda A, Mitsuishi Y, Motosugi Y, Saito Y, Hayashi K, Itoh H
    • Journal Title

      Hypertens Res

      Volume: 33(7) Pages: 753-4

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] NF-YC functions as a corepressor of agonist-bound mineralocorticoid receptor.2010

    • Author(s)
      Murai-Takeda A, Shibata H, Kurihara I, et al
    • Journal Title

      J Biol Chem

      Volume: 285(11) Pages: 8084-93

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 核内受容体と内分泌代謝疾患Update治療抵抗性高血圧におけるミネラルコルチコイド受容体の蛋白修飾による活性化機構2011

    • Author(s)
      柴田洋孝, 栗原勲, 三石木綿子, 林毅, 城理絵, 横田健一, 武田彩乃, 本杉裕一郎, 大山貴子, 伊藤裕
    • Organizer
      日本内分泌学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2011-04-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 術前検査で褐色細胞腫が疑われ、病理所見で多発する血管腫が確認された、石灰化を伴う副腎偶発腫瘍の一例2011

    • Author(s)
      栗原勲, 他
    • Organizer
      第84回日本内分泌学会総会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2011-04-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 原発性アルドステロン症の病型診断における血中18-水酸化ステロイド測定の有用性2010

    • Author(s)
      栗原勲, 柴田洋孝, 武田彩乃, 三石木綿子, 本杉裕一郎, 林毅, 城理絵, 宮下和季, 本間桂子, 伊藤裕
    • Organizer
      日本ステロイドホルモン学会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-11-27
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Pancreatic solid-pseudopapillary tumorが疑われた副腎偶発腫瘍の一例2010

    • Author(s)
      栗原勲, 他
    • Organizer
      日本内分泌病理学会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dihydropyridine calcium channel blockers have selective antagonist activity of steroid hormone receptors through blocking nuclear translocation of the receptor2010

    • Author(s)
      Isao Kurihara, Hirotaka Shibata, Yuko Mitsuishi, Ayano Murai-Takeda, Yuichiro Motosugi, Takashi Hayashi, Rie Jo, Hiroshi Itoh
    • Organizer
      国際内分泌学会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] Dihydropyridine calcium channel blockers have selective antagonist activity of steroid hormone receptors through blocking nuclear translocation of the receptor.2010

    • Author(s)
      Lsao Kurihara, et al.
    • Organizer
      ICE 2010(国際内分泌学会2010)
    • Place of Presentation
      京都国際会館
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] EGFによるミネラルコルチコイド受容体のアルドステロン感受性亢進の分子機構治療抵抗性高血圧における役割2010

    • Author(s)
      三石木綿子, 柴田洋孝, 栗原勲, 横田健一, 武田彩乃, 城理絵, 林毅, 本杉裕一郎, 伊藤裕
    • Organizer
      日本内分泌学会学術総会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-26
    • Related Report
      2011 Final Research Report
  • [Presentation] ジヒドロピリジン系Ca拮抗薬はCaチャンネル作用とは独立した新規ミネラルコルチコイド受容体拮抗作用を有する2009

    • Author(s)
      栗原勲, 柴田洋孝, 三石木綿子, 武田彩乃, 本杉裕一郎, 伊藤裕
    • Organizer
      日本高血圧学会
    • Place of Presentation
      大津
    • Year and Date
      2009-10-01
    • Related Report
      2011 Final Research Report
  • [Presentation] ジヒドロピリジン系Ca拮抗薬はCaチャンネル拮抗作用とは独立した新規ミネラルコルチコイド受容体拮抗作用を有する2009

    • Author(s)
      栗原勲, 他
    • Organizer
      第32回日本高血圧学会総会
    • Place of Presentation
      大津プリンス(滋賀)
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] ジヒドロピリジン系Ca拮抗薬のミネラルコルチコイド受容体拮抗作用の検討2009

    • Author(s)
      栗原勲、柴田洋孝、三石木綿子、横田健一、武田彩乃、本杉裕一郎、林毅、城理絵、伊藤裕
    • Organizer
      東京アルドステロンフォーラム
    • Place of Presentation
      東京
    • Year and Date
      2009-07-17
    • Related Report
      2011 Final Research Report
  • [Presentation] レニン・アンジオテンシン・アルドステロン系の新展開ジヒドロピリジン系Ca拮抗薬のミネラルコルチコイド受容体拮抗作用の検討2009

    • Author(s)
      栗原勲, 柴田洋孝, 三石木綿子, 武田彩乃, 本杉裕一郎, 伊藤裕
    • Organizer
      日本内分泌学会学術総会
    • Place of Presentation
      前橋
    • Year and Date
      2009-04-23
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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