|Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
The orexigenic hormone ghrelin has two major molecular forms : acylated ghrelin and desacyl ghrelin. Intracerebroventricularly administered desacyl ghrelin induces food intake in rodent by a mechanism independent of receptor for acylated ghrelin. However, desacyl ghrelin receptor is not yet identified. In this study, the cell lines endogenously expressing receptor for desacyl ghrelin were investigated. Desacyl ghrelin induced cAMP production in H9c2 and C2C12 cells in dose-dependent manner, suggesting that desacyl ghrelin receptor may be expressed in these cell lines.