| Project/Area Number |
21790918
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
TAKEUCHI Kyoko The University of Tokushima, 病院, 助教 (60511334)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | TGF-β / 多発性骨髄腫 / 骨髄腫 / 骨芽細胞 / 骨芽組胞 |
|---|
| Research Abstract |
Multiple myeloma develops and expands almost exclusively in the bone marrow, and generates devastating bone destruction. In bone lesions in myeloma, TGF-β is released from the bone and activated, which suppresses terminalosteoblast differentiation. Inhibition of TGF-β actions by TGF-β receptor type I kinase inhibitor enhances osteoblastic differentiation to mature osteoblasts. Furthermore, mature osteoblasts inhibit, while immature stromal cells enhance, myeloma cell growth and survival. Thus, inhibition of TGF-β signal may become a new therapeutic target against myeloma cell growth and destructive bone lesions.
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