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TGF-β inhibition restores terminal osteoblast differentiation to suppress myeloma growth

Research Project

Project/Area Number 21790918
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Hematology
Research InstitutionThe University of Tokushima

Principal Investigator

TAKEUCHI Kyoko  The University of Tokushima, 病院, 助教 (60511334)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsTGF-β / 多発性骨髄腫 / 骨髄腫 / 骨芽細胞 / 骨芽組胞
Research Abstract

Multiple myeloma develops and expands almost exclusively in the bone marrow, and generates devastating bone destruction. In bone lesions in myeloma, TGF-β is released from the bone and activated, which suppresses terminalosteoblast differentiation. Inhibition of TGF-β actions by TGF-β receptor type I kinase inhibitor enhances osteoblastic differentiation to mature osteoblasts. Furthermore, mature osteoblasts inhibit, while immature stromal cells enhance, myeloma cell growth and survival. Thus, inhibition of TGF-β signal may become a new therapeutic target against myeloma cell growth and destructive bone lesions.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (5 results)

All 2010 2009 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] TGF-β inhibition restores terminal osteoblast differentiation to suppress myeloma growth.2010

    • Author(s)
      Kyoko Takeuchi,Masahiro Abe, Masahiro Hiasa, Asuka Oda, Hiroe Amou, Shinsuke Kido, Takeshi Harada, Osamu Tanaka, Hirokazu Miki, Shingen Nakamura, Ayako Nakano, Kumiko Kagawa, Kenichiro Yata, Shuji Ozaki, Toshio Matsumoto.
    • Journal Title

      PLos ONE. 5(3)

    • Related Report
      2010 Final Research Report
  • [Journal Article] TGF-β Inhibition Restores Terminal Osteoblast Differentiation to Suppress Myeloma Growth2010

    • Author(s)
      竹内恭子
    • Journal Title

      PLoS One

      Volume: Mar 25 ; 5(3)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] TGF-βI型受容体(ALK5)阻害薬は骨芽細胞分化を誘導し骨髄腫腫瘍進展を抑制する2009

    • Author(s)
      竹内恭子
    • Organizer
      第13回日本がん分子標的治療学会
    • Place of Presentation
      徳島
    • Year and Date
      2009-06-26
    • Related Report
      2010 Final Research Report
  • [Presentation] TGF-β1型受容体(AKL5)阻害薬は骨芽細胞分化を誘導し骨髄腫腫瘍進展を抑制する2009

    • Author(s)
      竹内恭子
    • Organizer
      日本がん分子標的治療学会
    • Place of Presentation
      ホテルクレメント徳島(徳島県)
    • Year and Date
      2009-06-25
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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