TGF-β inhibition restores terminal osteoblast differentiation to suppress myeloma growth
| Project/Area Number |
21790918
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TAKEUCHI Kyoko The University of Tokushima, 病院, 助教 (60511334)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | TGF-β / 多発性骨髄腫 / 骨髄腫 / 骨芽細胞 / 骨芽組胞 |
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| Research Abstract |
Multiple myeloma develops and expands almost exclusively in the bone marrow, and generates devastating bone destruction. In bone lesions in myeloma, TGF-β is released from the bone and activated, which suppresses terminalosteoblast differentiation. Inhibition of TGF-β actions by TGF-β receptor type I kinase inhibitor enhances osteoblastic differentiation to mature osteoblasts. Furthermore, mature osteoblasts inhibit, while immature stromal cells enhance, myeloma cell growth and survival. Thus, inhibition of TGF-β signal may become a new therapeutic target against myeloma cell growth and destructive bone lesions.
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Report
(3 results)
Research Products
(5 results)
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[Journal Article] TGF-β inhibition restores terminal osteoblast differentiation to suppress myeloma growth.2010
Author(s)
Kyoko Takeuchi,Masahiro Abe, Masahiro Hiasa, Asuka Oda, Hiroe Amou, Shinsuke Kido, Takeshi Harada, Osamu Tanaka, Hirokazu Miki, Shingen Nakamura, Ayako Nakano, Kumiko Kagawa, Kenichiro Yata, Shuji Ozaki, Toshio Matsumoto.
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Journal Title
Related Report
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