Analysis of TNFAIP3 gene function in lymphomagenesis
| Project/Area Number |
21790929
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
HONMA Keiichiro 愛知県がんセンター(研究所), 遺伝子医療研究部, 主任研究員 (20505945)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 非ホジキンリンパ腫 / NF-κB / TNFAIP3 / 悪性リンパ腫 / NF-kB |
|---|
| Research Abstract |
Malignant lymphoma possess histologic and genetic diversity, hence understanding the mechanisms of each cases is important for improving their prognosis. In our present study, we analyzed several subsets of non-Hodgkin lymphomas and found that; (1) TNFAIP3/A20 gene is frequently altered in B-cell lymphoma with NF-kB activation. (2) TNFAIP3 may be involved in lymphomagenesis through inhibiting NF-kB. (3) Our study provides a novel insight into molecular mechanisms leading to lymphoma and that specific targeting of NF-kB pathways may be advantageous for treatment.
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Report
(3 results)
Research Products
(9 results)
