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Neurophysiological study in eye gaze perception in autism spectrum disorder

Research Project

Project/Area Number 21791118
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionKanazawa University

Principal Investigator

NAKATANI Hideo  金沢大学, 附属病院, 助教 (10452103)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords自閉症スペクトラム障害 / 視線認知 / 大脳生理学 / 脳磁図
Research Abstract

First, as a pilot study, we demonstrated the aberrant neural processing for eye gaze recognition in one subject with autism spectrum disorder(ASD). Based on this pilot study, we developed a visual stimulation task for eye gaze perception. During this task, we measured brain response in 20 typically developed(TD) adults using magnetoencephalography(MEG). We employed two different beamformer analyzes. One is DICS methods for time-locked gamma event related(de) synchronization. The other is LCMV methods for phase-locked evoked response. In both methods, we demonstrated robust brain responses around superior temporal sulcus and fusiform gyrus in TD adults. We could prepare the suitable stimulus and analysis methods for the neurophysiological study in ASD subject in future.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (3 results)

All 2012 2010

All Journal Article (3 results) (of which Peer Reviewed: 3 results)

  • [Journal Article] Spatiotemporal frequency characteristics of cerebral oscillations during the perception of fundamental frequency contour changes in one-syllable intonation2012

    • Author(s)
      Ueno S, Okumura E, Remijn GB, YoshimuraY, Kikuchi M, Shitamichi K, Nagao K, Mochiduki M, Haruta Y, Hayashi N, Munesue T, Tsubokawa T, Oi M, NakataniH, Higashida H, MinabeY.
    • Journal Title

      Neurosci Lett

      Volume: (in press) Issue: 2 Pages: 141-146

    • DOI

      10.1016/j.neulet.2012.03.031

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxytocin attenuates feelings of hostility depending on emotional context and individuals' characteristics2012

    • Author(s)
      Tetsu Hirosawa1, Mitsuru Kikuchi, Haruhiro Higashida, Eiichi Okumura, Sanae Ueno, Kiyomi Shitamichi, YukoYoshimura, Toshio Munesue, TsunehisaTsubokawa, Yasuhiro Haruta, Hideo Nakatani, Takanori Hashimoto, Yoshio Minabe
    • Journal Title

      Scientific Reports

      Volume: (in press) Issue: 1 Pages: 384-384

    • DOI

      10.1038/srep00384

    • NAID

      120005821069

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two genetic variants of CD38 in subjects with autism spectrum disorder and controls2010

    • Author(s)
      Munesue T, Yokoyama S, Nakamura K, Anitha A, Yamada K, Hayashi K, Asaka T, Liu HX, Jin D, Koizumi K, Islam MS, Huang JJ, Ma WJ, Kim UH, Kim SJ, ParkK, Kim D, Kikuchi M, Ono Y, Nakatani H, Suda S, Miyachi T, Hirai H, Salmina A, Pichugina YA, Soumarokov AA,Takei N, Mori N, Tsujii M, Sugiyama T, Yagi K, Yamagishi M, Sasaki T, Yamasue H, KatoN, Hashimoto R, Taniike M, Hayashi Y, Hamada J, Suzuki S, Ooi A, Noda M, Kamiyama Y, Kido MA, Lopatina O, Hashii M, Amina S, Malavasi F, Huang EJ, Zhang J, Shimizu N, Yoshikawa T, Matsushima A, Minabe Y, Higashida H.
    • Journal Title

      Neurosci Res

      Volume: 67(2) Issue: 2 Pages: 181-91

    • DOI

      10.1016/j.neures.2010.03.004

    • Related Report
      2011 Final Research Report
    • Peer Reviewed

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Published: 2009-04-01   Modified: 2016-04-21  

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