Interaction between salivary amylase and DEX/CRH tests in depression
Project/Area Number |
21791137
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Psychiatric science
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Research Institution | Oita University |
Principal Investigator |
TSURU Jusen Oita University, 医学部, 助教 (50527752)
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Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 不安障害 / うつ病 / アミラーゼ / DEX / CRH / コルチゾー |
Research Abstract |
Chronic stress has often induced dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis by. In comparison, psychosocial stress-induced activation of salivary α-amylase (sAA) functions as a marker of sympathoadrenal medullary system (SAM) activity. The present study measured sAA and salivary cortisol levels in patients with major depressive disorder. Tension-Anxiety, Depression-Dejection, Anger-Hostility, Fatigue, and Confusion scores in patients with major depressive disorder were significantly increased compared to healthy controls. SAA levels in major depressive disorder patients were significantly elevated compared with controls both before and after electrical stimulation. These preliminary results suggest that sAA might be a useful biological marker of major depressive disorder.
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Report
(3 results)
Research Products
(48 results)
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[Journal Article] Serum hepatocyte growth factor levels and the effects of antidepressants in panic disorder.2010
Author(s)
Masayuki Kanehisa, Yoshinobu Ishitobi, Tomoko Ando, Shizuko Okamoto, Yoshihiro Maruyama, Kentaro Kohno, Taiga Ninomiya, Haruka Higuma, Yoshihiro Tanaka, Jusen Tsuru, Hiroaki Hanada, Kensuke Kodama, Jotaro Akiyoshi.
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Journal Title
Neuropeptides 44
Pages: 431-435
Related Report
Peer Reviewed
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[Journal Article] Infrared radiation has potential antidepressant and anxiolytic effects in animal model of depression and anxiety.2010
Author(s)
Yoshihiro Tanaka, Jotaro Akiyoshi, Yoshinari Kawahara, Yoshinobu Ishitobi, Koji Hatano, Nobuhiko Hoaki, Ayumi Mori, Shinjiro Goto, Jusen Tsuru, Hirotaka Matushita, Hiroaki Hanada, Kensuke Kodama, Koichi Isogawa, Hirokazu Kitamura, Yoshihisa Fujikura.
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Journal Title
Brain Stimulation (published online)
Related Report
Peer Reviewed
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[Journal Article] Elevated salivary α-amylase and cortisol levels in unremitted and remitted depressed patients.2010
Author(s)
Yoshinobu Ishitobi, Jotaro Akiyoshi, Yoshihiro Tanaka, Tomoko Ando, Shizuko Okamoto, Masayuki Kanehisa, Kentaro Kohno, Taiga Ninomiya, Yoshihiro Maruyama, Jusen Tsuru, Aimi Kawano, Hiroaki Hanada, Koichi Isogawa, Kensuke Kodama.
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Journal Title
International Journal of Psychiatry in Clinical Practice. 14
Pages: 268-273
Related Report
Peer Reviewed
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[Journal Article] Social support and enhanced suppression of adrenocotropic hormone and cortisol responses to hypothalamic-pituitary-adrenal function and thyrotoropin-releasing hormone tests in patients with major depressive disorder.2008
Author(s)
Jusen Tsuru, Jotaro Akiyoshi, Yoshinobu Tanaka, Hirotaka Matsushita, Hiroaki Hanada, Kensuke Kodama, Takatoshi Hikichi, Hirochika Ohgami, Takashi Tsutsumi, Koichi Isogawa, Haruo Nagayama.
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Journal Title
Biological Psychology. 78
Pages: 159-163
Related Report
Peer Reviewed
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