The study of polymorphism of activation syndrome caused by antidepressant
| Project/Area Number |
21791149
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
HARADA Tsuyoto 東京女子医科大学, 医学部, 助教 (80385400)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 精神薬理学 / 抗うつ薬 / 副作用 / Activation syndrome / 自殺 |
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| Research Abstract |
We prospectively surveyed the cases of 282 patients who did not take any antidepressants for one month before visiting and were prescribed antidepressant during one month after initial visit. Patients were classified as developing AS if they experienced any symptom of anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia, hypomania and mania during the first one month. Differences in demographic and clinical variables between patients with and without activation syndromes were compared by means ofχ2 analysis, t test and multiple logistic regression analysis. This study suggests that the incidence of AS was 7.4% and first-degree relatives of persons with mood disorder and diagnosis of MDD may be a clinical predictor of activation syndrome.
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Report
(4 results)
Research Products
(5 results)
