2011 Fiscal Year Final Research Report

The study of polymorphism of activation syndrome caused by antidepressant

Research Project

Project/Area Number	21791149
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Psychiatric science
Research Institution	Tokyo Women's Medical University
Principal Investigator	HARADA Tsuyoto 東京女子医科大学, 医学部, 助教 (80385400)
Project Period (FY)	2009 – 2011
Keywords	精神薬理学 / 抗うつ薬 / 副作用 / Activation syndrome / 自殺
Research Abstract	We prospectively surveyed the cases of 282 patients who did not take any antidepressants for one month before visiting and were prescribed antidepressant during one month after initial visit. Patients were classified as developing AS if they experienced any symptom of anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia, hypomania and mania during the first one month. Differences in demographic and clinical variables between patients with and without activation syndromes were compared by means ofχ2 analysis, t test and multiple logistic regression analysis. This study suggests that the incidence of AS was 7.4% and first-degree relatives of persons with mood disorder and diagnosis of MDD may be a clinical predictor of activation syndrome.

(2 results)