| Project/Area Number |
21791425
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Clinical research Center, National Hospital Organization Murayama Medical Center (2010)
Clinical research Center, National Hospital Organization Murayama Medical Center (2009) |
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Principal Investigator |
KANEKO Shinjiro 独立行政法人国立病院機構村山医療センター(臨床研究センター), 整形外科, 医長 (10327554)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 脊髄損傷 / 軸索再生 / drug delivery system / リハビリテーション / 脊髄損傷(SCI) / 軸索再生阻害因子 / Semaphorin3A / Semaphorin3A阻害剤 / contusion損傷 |
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| Research Abstract |
In this study, aiming for clinical use, we administered newly-developed potent Semaphorin3A inhibitor, SM-345431 (Vinaxanthone), by a novel and our original drug delivery system using silicone sheet which enables continuous drug delivery during the period of the experiment. Treatment with SM-345431 using this delivery system enhanced axon regeneration with significant but limited hindlimb motor function recovery as reported previously. Although extensive treadmill training with SM-345431 administration did not further improve axon regeneration, hindlimb motor performance was increased, as evidenced by the significant improvement in the execution of plantar steps on a treadmill. Further analyses suggested that this strategy reinforced the wiring of central pattern generators in lumbar spinal circuits, which in turn led to enhanced motor function recovery (especially in extensor muscles).
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