Strategy for elucidating the mechanism controlling axonal regeneration and achieving enhanced axonal regeneration after spinal cord injury
| Project/Area Number |
21791425
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Clinical research Center, National Hospital Organization Murayama Medical Center (2010)
Clinical research Center, National Hospital Organization Murayama Medical Center (2009) |
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Principal Investigator |
KANEKO Shinjiro 独立行政法人国立病院機構村山医療センター(臨床研究センター), 整形外科, 医長 (10327554)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 脊髄損傷 / 軸索再生 / drug delivery system / リハビリテーション / 脊髄損傷(SCI) / 軸索再生阻害因子 / Semaphorin3A / Semaphorin3A阻害剤 / contusion損傷 |
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| Research Abstract |
In this study, aiming for clinical use, we administered newly-developed potent Semaphorin3A inhibitor, SM-345431 (Vinaxanthone), by a novel and our original drug delivery system using silicone sheet which enables continuous drug delivery during the period of the experiment. Treatment with SM-345431 using this delivery system enhanced axon regeneration with significant but limited hindlimb motor function recovery as reported previously. Although extensive treadmill training with SM-345431 administration did not further improve axon regeneration, hindlimb motor performance was increased, as evidenced by the significant improvement in the execution of plantar steps on a treadmill. Further analyses suggested that this strategy reinforced the wiring of central pattern generators in lumbar spinal circuits, which in turn led to enhanced motor function recovery (especially in extensor muscles).
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Report
(3 results)
Research Products
(24 results)
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[Presentation] Activin/TGF β signal による脊髄後根神経節neuronの軸索伸長/再生能の制御-target/皮膚に由来するsignalの関与-2010
Author(s)
金子慎二郎, Ying Chen, Kai Liu, Zhigang He, 町田正文, 塩田匡宣, 竹光正和, 福田健太郎, 宝亀登, 池上健, 加藤裕幸, 飯塚慎吾, 名越慈人, 山岸正明, 岡野栄之, 戸山芳昭, 中村雅也
Organizer
第63回国立病院総合医学
Place of Presentation
仙台国際センター
Year and Date
2010-10-23
Related Report
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[Presentation] Activin/TGF βsignalによるDRG neuronの軸索伸長/再生能の制御-target/皮膚に由来するsignalの関与-2010
Author(s)
金子慎二郎, Ying Chen, KaiLui, Zhigang He, 町田正文, 塩田匡宣, 竹光正和, 福田健太郎, 池上健, 加藤裕幸, 飯塚慎吾, 名越慈人, 五十嵐一峰, 山岸正明, 岡野栄之, 戸山芳昭, 中村雅也
Organizer
第9回日本再生医療学会
Place of Presentation
広島国際会議場(広島市)
Year and Date
2010-03-19
Related Report
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[Presentation] 神経変性疾患に於ける軸索保護へ向けた新たなstrategy-多発性硬化症モデルEAEに於けるNADを用いた軸索保護-2010
Author(s)
金子慎二郎, Jing Wang, Zhigang He, 町田正文, 塩田匡宣, 竹光正和, 福田健太郎, 池上健, 加藤埜圭, 飯塚慎吾, 名越慈人, 五十嵐一峰, 山岸正明, 岡野栄之, 戸山芳昭, 中村雅也
Organizer
第9回日本再生医療学会
Place of Presentation
広島国際会議場
Year and Date
2010-03-10
Related Report
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[Presentation] Activin/TGF β signaling suppresses the axonaloutgrowth and regenerative ability in sensory neurons2009
Author(s)
Kaneko S, Ying Chen, Kai Liu, Kuwako K, Zhigang He, Machida M, Shioda M, Yamagishi M, Okano H, Toyama Y, Nakamura M:
Organizer
第24回日本整形外科学会基礎学術集会
Place of Presentation
パシフィコ横浜
Year and Date
2009-11-05
Related Report
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[Presentation] 神経変性疾患に於ける軸索保護へ向けた新たなstrategy-多発性硬化症動物モデル(EAE model)に於けるNADを用いた軸索保護-2009
Author(s)
金子慎二郎, Jing Wang, Zhigang He, 町田正文, 塩田匡宣, 竹光正和, 福田健太郎, 宝亀登, 池上健, 加藤裕幸, 飯塚慎吾, 名越慈人, 山岸正明, 岡野栄之, 戸山芳昭, 中村雅也
Organizer
第63回国立病院総合医
Place of Presentation
仙台国際センター
Year and Date
2009-10-23
Related Report
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